Streptozotocin
Physical and chemical properties History of discovery Animal diabetes inducer Uses- Product Name
- Streptozotocin
- CAS No.
- 18883-66-4
- Chemical Name
- Streptozotocin
- Synonyms
- STZ;STREPTOZOCIN;STR;ZANOSAR;strz;U-9889;nsc85998;nsc-85598;nsc-85998;nci-c03167
- CBNumber
- CB1476758
- Molecular Formula
- C8H15N3O7
- Formula Weight
- 265.22
- MOL File
- 18883-66-4.mol
Streptozotocin Property
- Melting point:
- 121 °C (dec.) (lit.)
- alpha
- D25 +39°
- Boiling point:
- 408.44°C (rough estimate)
- Density
- 1.4410 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml)
- form
- powder
- pka
- pKa 1.3 (Uncertain)
- color
- white to light yellow
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 13,8912
- BRN
- 2060675
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
- InChIKey
- ZSJLQEPLLKMAKR-FEQHFJGESA-N
- CAS DataBase Reference
- 18883-66-4
- IARC
- 2B (Vol. 17, Sup 7) 1987
- EPA Substance Registry System
- Streptozotocin (18883-66-4)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 40-61-46-45-22-20/21/22
- Safety Statements
- 36/37-53-45-36-22
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- LZ5775000
- F
- 3-10-21
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419090
- Hazardous Substances Data
- 18883-66-4(Hazardous Substances Data)
- Toxicity
- LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H228Flammable solid
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- S0130
- Product name
- Streptozocin
- Purity
- ≥75% α-anomer basis, ≥98% (HPLC), powder
- Packaging
- 1g
- Price
- $367
- Updated
- 2024/03/01
- Product number
- S0130
- Product name
- Streptozocin
- Purity
- ≥75% α-anomer basis, ≥98% (HPLC), powder
- Packaging
- 5g
- Price
- $1610
- Updated
- 2024/03/01
- Product number
- J61601
- Product name
- Streptozotocin, 97+%
- Packaging
- 500mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- J61601
- Product name
- Streptozotocin, 97+%
- Packaging
- 1g
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 13104
- Product name
- Streptozotocin
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $25
- Updated
- 2024/03/01
Streptozotocin Chemical Properties,Usage,Production
Physical and chemical properties
Light yellow crystalline powder, soluble in water, but its water solution is very unstable at room temperature,which can be broken down intothe gas evaporates after a half-hour , it takes using now. Dissolved in lower alcohols and ketones degrees, insoluble in polar organic solvents.
History of discovery
Streptozocin is produced by streptococcal bacteria ,it is natural compound which has a specific toxicity on mammalian insulin-producing pancreas islet B cells, it is a nitrosourea antibiotic, it is different from fat-soluble nitrosourea ,in chloroethyl place it is a methyl group at the other end of the molecule it is an amino sugar, Streptozocin can break down reactive methyl positive carbon ions alone, and forms cross-links between the chains with DNA , so that it can lead to the DNA alkylation, but its alkylation is weaker than other nitrosourea drugs, and its metabolite methylsulfinyl nitrosourea’s alkylation is 3 to 4 times stronger than its STZ . STZ can form isocyanates in the body . It can combine with Nucleic acid protein and thereby inhibit DNA polymerase vitality,to make it difficult to repair damaged DNA. In the late 1950s,it was discovered at the beginning considered to be an antibiotic, scientists from the pharmaceutical company Upjohn in Kalamazoo (now a subsidiary of Pfizer) found STZ in the soil Streptomyces strains. In the mid-1960s, it was discovered that Streptozocin has specific toxicity on insulin-producing pancreatic B cells . This discovery makes STZ later used in animal model of diabetes and used to treat pancreatic B cell tumors.from 1860s to the 1870s, the US National Cancer Institute began to study Streptozocin application in chemotherapy. Upjohn Company in November 1976 applied for FDA approval for its treatment of pancreatic cancer, and in July 1982 it was approved. After that ,it has been using the trade name Zanosar. It is used to treat pancreatic islet cell tumors (β cells or non-β cell carcinoma) clinically, it has a certain effect on for carcinoid tumor, Hodgkin's disease, colon cancer and liver cancer . It is used to Establish an animal model of type 1 diabetes in medical research.
Animal diabetes inducer
Diabetes is a common metabolic endocrine disease, the main causes are due to relative or absolute lack of insulin, which is characterized by high blood sugar and diabetes. Experimental drugs can be used (such as alloxan and Streptozocin , etc.) to selectively destroy pancreatic β-cells, resulting in elevated blood glucose levels to make experimental diabetic mice.
Streptozocin (referred STZ) is a induced diabetic agent , it has an selectively destructive effect on a certain species of animals islet β cells ,which can induce diabetes in many animals, but they do not include the guinea pigs and humans, the general manufacture of animal models usually uses rats and mice. Foreign scholars reported that the incidence of diabetes in male rats selected manufacturing model is significantly higher than in female rats. Type 1 diabetes and type 2 diabetes animal models preparation is related to STZ injection dose: when bolus injection, as a direct result of the extensive destruction of pancreatic β cells,it can cause type 1 diabetes model; and when a relatively small amount STZ injection, since it just destroys part of the islet β cell function, resulting in peripheral tissues insensitive to insulin , while giving high-calorie diet, the combination will induce a animal model whose pathological, physiological changes are both close to human type 2 diabetes.
The above information is edited by the Chemicalbook of Tian Ye.
Uses
It is a compound containing N-nitroso ,it acts as a nitric oxide donor in pancreatic islets ; it can induce the death of diabetic animal model style of insulin-secreting cells . Efficient DNA methylation agent, can induce chromosome breakage.it has cell toxicity On the neuroendocrine tumor cell lines with the expression of GLUT2 glucose transporter (GLUT2 glucose transporter) . Streptozocin is used for inducing Type 1 diabetes in Medical researches .
Description
Streptozotocin (STZ) was originally identified in the late 1950s as an antibiotic and was discovered in a strain of the soil microbe Streptomyces achromogenes. In the mid-1960s, STZ was found to be selectively toxic to the beta cells of the pancreatic islets and thus it is used in animal model of diabetes and as a medical treatment for cancers of the beta cells. STZ’s use in cancer chemotherapy received Food and Drug Administration approval in July 1982 and the drug was subsequently marketed as Zanosar.
Chemical Properties
off-white to pale yellow crystalline powder
Originator
Zanosar,Upjohn,US,1982
Uses
antineoplastic, alkylating agent
Uses
Streptozotocin is used in the treatment metastatic cancer of the pancreatic islet cells. Streptozotocin has a highlrisk of toxicity and is generally limited to cancers that are inoperable.
Uses
somatostatin octapeptide analog
Uses
Streptozotocin is an unusual aminoglycoside containing a nitrosoamino group produced by Streptomyces achromogenes and discovered in 1959 as an antibiotic. The nitrosoamino group enables the metabolite to act as a nitric oxide (NO) donor. NO is an important messenger molecule involved in many physiological and pathological processes in the body. Streptozotocin is also widely used to induce diabetes in rodent models by inhibition of β-cell O-GlcNAcase.
Definition
ChEBI: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Indications
Streptozocin (Zanosar), a water-soluble nitrosourea
produced by the fungus Streptomyces achromogenes,
acts through methylation of nucleic acids and proteins.
In addition, it produces rapid and severe depletion of
the pyridine nucleotides nicotinamide adenine dinucleotide
(NAD) and its reduced form (NADH) in liver
and pancreatic islets.
Streptozocin is not well absorbed from the gastrointestinal
tract and must be administered intravenously or
intraarterially. In preclinical studies, the plasma half-life
was 5 to 10 minutes.
Streptozocin produces remission in 50 to 60% of patients
with islet cell carcinomas of the pancreas. It is also
useful in malignant carcinoid tumors.
Almost all patients have nausea and vomiting. The
major toxicity is renal tubular damage, which may be severe
in 5 to 10% of patients taking streptozocin.
Treatment of metastatic insulinomas may result in the
release of insulin from the tumor and subsequent hypoglycemic
coma. Less severe toxicities include diarrhea,
anemia, and mild alterations in glucose tolerance or
liver function tests.
Manufacturing Process
On a sterile maltose-tryptone agar slant of the following composition: 1 g
maltose; 0.5 g tryptone; 0.05 g K2HPO4; 0.01 g FeSO4·7H2O; 1.5 g agar; and
sufficient distilled water to make 100 ml, Streptomyces achromogenes var.
streptozoticus was grown for 7 days at 28°C.
The culture thus produced was used as an inoculum for the following sterile
medium: 1 g glucose; 1 g beef extract; 0.5 g Bacto peptone (Difco); 0.5 g
NaCl; and sufficient distilled water to make 100 ml. The pH was adjusted to
7.0 before sterilization. The inoculated medium was incubated in shake flasks
for 3 days at 28°C on a reciprocating shaker and 75 ml of the resulting
growth was used to inoculate 12 l of sterile medium of the same formulation.
The medium was incubated in a 20 l stainless steel bottle, at 28°C for 2 days,
the contents being stirred continuously with sparged air at the rate of 6 l of
free air per minute. The resulting growth was used to inoculate 250 l of the
following sterile medium. 2 g Bacto peptone (Difco); 2.5 g blackstrap
molasses; 2 g glucose; 0.25 g NaCl; and sufficient distilled water to make 100
ml. The pH was adjusted to 7.0 before sterilization.
This medium was incubated in a 100 gallon stainless steel fermentor, at 24°C
with sparged air being introduced at the rate of 50 l/min and with agitation by
an impeller. After 66 hours of fermentation the beer was harvested. To 100
gallons of harvested beer was added 17 pounds of diatomite, and 35 pounds
of activated carbon. The mixture was stirred well and then filtered, the cake
was water-washed with 10 gallons of tap water, and then washed with 25
gallons of acetone followed by 30 gallons of 1:1 aqueous acetone. The
acetone solutions of streptozotocin were pooled and dried in vacuo to 3.88
pounds.
brand name
Zanosar (Sicor).
Therapeutic Function
Antineoplastic
General Description
Streptozocin is available in 1-g vials for IV administrationin the treatment of metastatic islet cell carcinoma of the pancreas,colon cancer, and Hodgkin’s disease. Activation resultsin the formation of methyl carbonium ions, which alkylateDNA, but the agent is less effective in alkylating DNAand carbamylating proteins than other nitrosoureas, which isbecause in part of an intramolecular carbamoylation. The internalcarbamate group migration occurs via the hydroxylgroups of the glucose portion of the molecule. There is a reducedeffect on RNA function compared with other nitrosoureasas well. The hydrophilic agent is rapidly clearedfrom the plasma with an elimination half-life of 35 minutes.The presence of the glucose moiety allows for utilization ofglucose transporters, which concentrate the compound inthe -cells of the pancreas. The metabolism of the agent hasnot been well characterized. Renal toxicity is dose limitingand may present initially as proteinuria and azotemia butmay progress to renal failure. Nausea and vomiting may besevere with the agent, whereas myelosuppression is generallymild. Normal glucose metabolism may be altered sothat hypoglycemia or hyperglycemia may be seen. In someanimal species, streptozocin produces diabetes but muchmilder effects are seen in man.
General Description
Off-white powder. Melting point 115°C. Used as an anti-cancer drug. Carcinogenic.
Air & Water Reactions
Water soluble.
Reactivity Profile
[D-GLUCOSE, 2-DEOXY-2-[[(METHYLNITROSOAMINO)-CARBONYL]AMINO] is weakly basic. Reacts exothermically with acids. Reacts with both strong oxidizing agents and strong reducing agents.
Biological Activity
Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β -cells in vivo .
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Clinical Use
The glucopyranose moiety of streptozocin confers both islet cell specificity and high water solubility to this nitrosourea-based antineoplastic. As a result, it is used exclusively in metastatic islet cell carcinoma of the pancreas and is administered IV in D5W or normal saline.
Side effects
Lacking the 2-chloroethyl substituent of carmustine and lomustine, it is much less reactive as a DNA alkylating agent, and myelotoxicity is relatively rare but not unknown. Cumulative, dose-related renal toxicity can be severe or fatal, however, and 67% of patients receiving this drug will exhibit some kidney-related pathology.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Experimental poison by intravenous, parenteral, subcutaneous, and intraperitoneal routes. Moderately toxic to humans by intravenous route. Human systemic effects: nausea or vomiting, impaired liver function, kidney changes. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES.
Veterinary Drugs and Treatments
At present the primary purpose for streptozocin use in veterinary medicine is as a treatment for insulinomas in dogs, particularly those with refractory hypoglycemia and when tumors are nonresectable or have metastasized. Streptozocin potentially could be used for other oncologic conditions as well.
Carcinogenicity
Streptozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
STZ is an odorless ivory-colored crystalline powder or pale yellow crystals. Having the solubility of 5070 mg l-1 in water at 25 °C, STZ is soluble in alcohol and ketones and slightly soluble in polar organic solvents and insoluble in nonpolar organic solvents. STZ is produced by the soil microorganism and therefore isolated from soil samples that assumed a source of release to the environment. Vapor pressure and Henry’s law constant of STZ are 1.74E-12 mm Hg and 1.08E-10 cm3 per molecule-sec at 25 °C, respectively. No information is currently available for partition behavior in water, sediment, and soil; environmental persistency, long-range transport, or bioaccumulation/ biomagnification.
storage
-20°C
Purification Methods
Recrystallise streptozotocin from 95% EtOH. It is soluble in H2O, MeOH and Me2CO. It has UV max at 228nm ( 6360) in EtOH. The tetraacetate has m 111-114o(dec), and [] D 25 +41o (c 0.78, 95% EtOH) after recrystallisation from EtOAc. [Herr et al. J Am Chem Soc 89 4808 1967, NMR: Wiley et al. J Org Chem 44 9 1979.] It is a potent methylating agent for DNA [Bennett & Pegg Cancer Res 41 2786 1981].
Toxicity evaluation
STZ as an antibiotic is effective against Gram-negative bacteria. As a diabetogenic agent, STZ by its N-nitroso group acts as a nitric oxide donor in pancreatic islets. STZ inhibits synthesis of DNA in microorganisms and mammalian cells by alkylation and cross-linking the strands of DNA, and also affects on all stages of mammalian cell cycle. STZ-induced DNA damage causes activation of poly ADP-ribosylation, which is important in induction of diabetes rather than DNA damage. Biochemical studies indicated that STZ inhibits pyridine nucleotides and the key enzymes that are involved in glyconeogenesis. STZ transports glucose into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. Since beta cells have relatively high levels of GLUT2, this explains STZ’s relative toxicity in these cells.
References
1) Szkudelski?et al. (2001),?The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.; Physiol. Res.,?50?537 2) Bennett & Pegg (1981),?Alkylation of DNA in rat tissues following administration of streptozotocin; Cancer Res.,?41?27861 3) Konrad?et al.?(2001),?The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase; Biochem. J.,?356 Pt 1?31 4) Gao?et al.?(2000),?Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells; Arch. Biochem. Biophys.,?383?296 5) Kroncke & Kolb-Bachofen (1996),?Streptozotocin is not a spontaneous NO donor.; Free Radic. Res.,?24?77
Streptozotocin Preparation Products And Raw materials
Raw materials
Preparation Products
Streptozotocin Suppliers
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4654
- Advantage
- 58
- Tel
- 027-83991130 18627774460
- Fax
- 027-83991130
- 1718093273@QQ.COM
- Country
- China
- ProdList
- 1891
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 0731-85561020 15386497078
- yunbang@yunbangapi.com
- Country
- China
- ProdList
- 4152
- Advantage
- 58
- Tel
- 0731-85561035 13319583233
- yongqi@yongqichem.com
- Country
- China
- ProdList
- 1006
- Advantage
- 58
- Tel
- 021-62130998
- Fax
- 021-54438215
- baomanbio@163.com
- Country
- China
- ProdList
- 105
- Advantage
- 55
- Tel
- 027-027-83984790 17720532645
- Fax
- 027-83984790
- t17720532645@163.com
- Country
- China
- ProdList
- 1000
- Advantage
- 58
- Tel
- 027-59101766 13125137661
- 2853877621@qq.com
- Country
- China
- ProdList
- 3222
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9984
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 18089
- Advantage
- 64
- Tel
- 025-58619198
- Fax
- 025-58619197
- sales@mbbio.com
- Country
- China
- ProdList
- 319
- Advantage
- 60
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4550
- Advantage
- 62
- Tel
- +86-028-60911900 13540204019
- sales@afbiochem.com
- Country
- China
- ProdList
- 493
- Advantage
- 57
- Tel
- 0370-2785118 15343847665
- Fax
- QQ：3470079902
- huawenchem@163.com
- Country
- China
- ProdList
- 3205
- Advantage
- 55
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9725
- Advantage
- 55
- Tel
- +86-28-61777709
- Fax
- +86-28-61777709
- yygk@yygk.com
- Country
- China
- ProdList
- 69
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9901
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9552
- Advantage
- 55
- Tel
- +86-21-65211385-8001 36031160
- Fax
- +86-21-65211385-8004
- sales@shruji.com
- Country
- China
- ProdList
- 3224
- Advantage
- 55
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 025-84699383-8003 18013301590
- Fax
- 025-84699383-8003
- njduly@126.com
- Country
- China
- ProdList
- 973
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 021-61995394 18916691159
- chemicalsea@163.com
- Country
- China
- ProdList
- 1975
- Advantage
- 58
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3924
- Advantage
- 50
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9986
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 400-1500-680 021-62402299
- Fax
- 021-62402299
- nancy.cai@mpbio.com
- Country
- China
- ProdList
- 125
- Advantage
- 60
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4951
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
View Lastest Price from Streptozotocin manufacturers
- Product
- Streptozotocin 18883-66-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 1000
- Release date
- 2024-05-10
- Product
- Streptozotocin 18883-66-4
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/MONTH
- Release date
- 2024-04-24
- Product
- Streptozotocin 18883-66-4
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20000
- Release date
- 2023-12-28