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PSMA-617

Product Name
PSMA-617
CAS No.
1702967-37-0
Chemical Name
PSMA-617
Synonyms
PSMA-617;Vipivotide tetraxetan;PSMA617,Vipivotide tetraxetan;Vipivotide tetraxetan (PSMA-617);Vipivotide tetraxetan (PSMA617 TFA);Actinium-225-PSMA-Trillium(BAY3563254);Vipivotide tetraxetan (PSMA-617) ，S8670;N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl];(2S)-2-({[(1S)-1-carboxy-5-[(2S)-3-(naphthalen-2-yl)-2-{[(1s,4s)-4-[(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl]cyclohexyl]formamido}propanamido]pentyl]carbamoyl;L-Lysine, N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]-
CBNumber
CB14796685
Molecular Formula
C49H71N9O16
Formula Weight
1042.14
MOL File
1702967-37-0.mol
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PSMA-617 Property

Boiling point:
1371.9±65.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Water:150.0(Max Conc. mg/mL);100.13(Max Conc. mM)
DMSO:125.0(Max Conc. mg/mL);83.43(Max Conc. mM)
form 
Solid
pka
1.83±0.10(Predicted)
color 
White to off-white
InChIKey
JBHPLHATEXGMQR-LFWIOBPJSA-N
SMILES
C(O)(=O)[C@H](CCCCNC(=O)[C@H](CC1=CC=C2C(=C1)C=CC=C2)NC([C@@H]1CC[C@@H](CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)CC1)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P143100
Product name
PSMA-617
Packaging
1mg
Price
$125
Updated
2021/12/16
TRC
Product number
P143100
Product name
PSMA-617
Packaging
2.5mg
Price
$280
Updated
2021/12/16
TRC
Product number
P143100
Product name
PSMA-617
Packaging
10mg
Price
$1010
Updated
2021/12/16
ChemScene
Product number
CS-0065894
Product name
Vipivotidetetraxetan
Purity
99.38%
Packaging
10mg
Price
$1250
Updated
2021/12/16
ChemScene
Product number
CS-0065894
Product name
Vipivotidetetraxetan
Purity
99.38%
Packaging
25mg
Price
$2550
Updated
2021/12/16
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PSMA-617 Chemical Properties,Usage,Production

Uses

PSMA-617 has been used in prostate cancer research, and is a promising prostate-specific membrane antigen-targeted theranostic agent.

in vivo

Organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617) after 1 h (n=3) reveals a high specific uptake in LNCaP tumors and in the kidneys. The high uptake in the kidneys is nearly completely blocked by coinjection of 2 mg of 2-PMPA per kilogram. Other organs such as the liver, lung, and spleen show rather low uptake and no blocking effect, with the exception of the spleen. Tumor-to-background ratios are 7.8 (tumor to blood) and 17.1 (tumor to muscle) at 1 h after injection. As compared with the 68Ga-labeled version, the organ distribution with 177Lu-labeled Vipivotide tetraxetan (PSMA-617) (n=3) show a similar uptake in the LNCaP tumors and in the kidneys. The liver uptake is found to be statistically different. Tumor-to-background ratios determined 1 h after injection show slightly higher values (tumor to blood, 22.1; tumor to muscle, 25.6) than previous organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617)[1].

IC 50

Traditional Cytotoxic Agents

PSMA-617 Preparation Products And Raw materials

Raw materials

Preparation Products

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PSMA-617 Suppliers

China 53 United States 4 Global 57
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
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View Lastest Price from PSMA-617 manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
PSMA-617 1702967-37-0
Price
US $0.00/GRAM
Min. Order
1GRAM
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-04
Xian confluore Biological Technology Co., Ltd.
Product
PSMA-617 1702967-37-0
Price
US $0.00/mg
Min. Order
10mg
Purity
>95.00%
Supply Ability
10mg
Release date
2024-04-01

1702967-37-0, PSMA-617Related Search:

Vipivotide tetraxetan Linker

  • PSMA-617
  • Vipivotide tetraxetan
  • L-Lysine, N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]-
  • Vipivotide tetraxetan (PSMA-617)
  • PSMA617,Vipivotide tetraxetan
  • Actinium-225-PSMA-Trillium(BAY3563254)
  • (((S)-1-Carboxy-5-((S)-3-(naphthalen-2-yl)-2-((1r,4S)-4-((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl)cyclohexane-1-carboxamido)propanamido)pentyl)carbamoyl)-L-glutamic acid
  • (2S)-2-({[(1S)-1-carboxy-5-[(2S)-3-(naphthalen-2-yl)-2-{[(1s,4s)-4-[(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl]cyclohexyl]formamido}propanamido]pentyl]carbamoyl
  • Vipivotide tetraxetan (PSMA617 TFA)
  • Vipivotide tetraxetan (PSMA-617) ，S8670
  • N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]
  • 1702967-37-0
  • C49H71N9O16
  • ADC