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Ginsenoside Rg2

Product Name
Ginsenoside Rg2
CAS No.
52286-74-5
Chemical Name
Ginsenoside Rg2
Synonyms
CHIKUSETSUSAPONIN I;anaxatriol;GinsesideRg2;Panaxoside Rg2;product/154570;Ginsenosdie Rg2;PROSAPOGENIN C2;GINSENOSIDE RG2;mannopyranosyl)-;iGInsenoside Rg2
CBNumber
CB1483174
Molecular Formula
C42H72O13
Formula Weight
785.03
MOL File
52286-74-5.mol
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Ginsenoside Rg2 Property

Melting point:
187～189℃
Boiling point:
881.0±65.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Methanol (Slightly, Heated, Sonicated), Pyridine (Slightly, Sonicated)
pka
12.85±0.70(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
AGBCLJAHARWNLA-DJZXLMSJSA-N
LogP
6.830 (est)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
LZ6430000
HS Code 
29389090
Toxicity
mouse,LD50,intraperitoneal,1340mg/kg (1340mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89680
Product name
Ginsenoside Rg2
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$391
Updated
2025/07/31
Sigma-Aldrich
Product number
08171
Product name
Ginsenoside Rg2
Purity
analytical standard
Packaging
10mg
Price
$408
Updated
2025/07/31
Cayman Chemical
Product number
15331
Product name
Ginsenoside Rg2
Purity
≥98%
Packaging
500μg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15331
Product name
Ginsenoside Rg2
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
15331
Product name
Ginsenoside Rg2
Purity
≥98%
Packaging
5mg
Price
$191
Updated
2024/03/01
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Ginsenoside Rg2 Chemical Properties,Usage,Production

Description

Ginsenosides are pharmacologically active natural compounds from ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg2 is a protopanaxatriol that is more abundant in some Panax species (e.g., white and red P. ginseng) than others. This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-diabetic actions. It also protects against DNA damage and apoptosis induced by ultraviolet light. Notably, this ginsenoside is increased by the metabolism of other bioactive ginsenosides during the steaming or heating of plant materials, particularly in P. quinquefolium.

Chemical Properties

White solid

Uses

20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng.

Definition

ChEBI: Ginsenoside Rg2 is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, a cardioprotective agent and an anticoagulant. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a ginsenoside, a tetracyclic triterpenoid, a disaccharide derivative, a 20-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

in vivo

G-Rg1 and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer's disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with G-Rg1 and Ginsenoside Rg2 (G-Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with G-Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. G-Rg1 and Ginsenoside Rg2 reduce Aβ1-42 accumulation in APP/PS1 mice. In the G-Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible[2].

IC 50

NF-κB; Aβ1-42

References

[1] GUIZHI ZHANG . Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia[J]. Journal of ethnopharmacology, 2008, 115 3: Pages 441-448. DOI: 10.1016/j.jep.2007.10.026
[2] YOUNG-SUK CHO. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell.[J]. Korean Journal of Physiology & Pharmacology, 2013, 17 2: 133-137. DOI: 10.4196/kjpp.2013.17.2.133
[3] HAI-DAN YUAN. Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells[J]. Chemico-Biological Interactions, 2012, 195 1: Pages 35-42. DOI: 10.1016/j.cbi.2011.10.006
[4] SE EUN HA. Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2010, 382 1: 89-101. DOI: 10.1007/s00210-010-0522-9
[5] IL-WOUNG KIM. A new validated analytical method for the quality control of red ginseng products.[J]. Journal of Ginseng Research, 2013, 37 4: 475-482. DOI: 10.5142/jgr.2013.37.475

Ginsenoside Rg2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ginsenoside Rg2 manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Ginsenoside Rg2 52286-74-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-08
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Ginsenosdie Rg2 52286-74-5
Price
US $286.00/KG
Min. Order
1KG
Purity
10%
Supply Ability
50KG
Release date
2020-03-04
Career Henan Chemical Co
Product
Ginsenoside Rg2 52286-74-5
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

52286-74-5, Ginsenoside Rg2Related Search:

Ginsenoside Rh1 Ginsenoside Rg1 std.,GINSENOSIDE RG1,Ginsenoside Rg1 (CAS# 22427-39-0),GINSENOSIDE RG1 WITH HPLC,GINSENOSIDE-RG1 (GINSENOSIDE A2: GINSENOSIDE G1) Ginsenoside-Rg5 Ginsenoside Rb3 Ginsenoside Rk3 Ginsenoside Rd GINSENOSIDE RB2 Ginsenoside Rh2 GinsenosideRo GINSENOSIDEF1 Ginsenoside Re Ginsenoside Rf Ginsenoside Rb1 ginsenoside Rh3 ginsenoside Rh(4) Ginsenoside Rg6 Ginsenoside Rc Panaxadiol

  • anaxatriol
  • beta-d-glucopyranoside,(3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en
  • mannopyranosyl)-
  • trihydroxydammar-24-en-6-yl2-O-(6-deoxy-α-L-
  • β-D-Glucopyranoside,(3β,6α,12β)-3,12,20-
  • Ginsenoside 20(s)-Rg2
  • (20S)-Ginsenoside Rg2
  • [3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
  • [3β,12β,20-Trihydroxydammar-24-en-6α-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
  • 6α-(2-O-α-L-Rhamnopyranosyl-β-D-glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol
  • GINSENOSIDE Rg2(SH)
  • Ginsenoside Rg2 ,98%
  • GinsesideRg2
  • iGInsenoside Rg2
  • b-D-Glucopyranoside, (3b,6a,12b)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-
  • Ginsenosdie Rg2
  • PROSAPOGENIN C2
  • GINSENOSIDE RG2
  • CHIKUSETSUSAPONIN I
  • CHIKUSETSUSAPONIN I, PROSAPOGENIN C2
  • (6)-(alpha-l-rhamnopyranosyl(1-rham-2-glu)-beta-d-glucopyranosyl)-20s-protop
  • -6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)-
  • (3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
  • Ginsenoside Rg2 (Chikusetsusaponin I
  • Panaxoside Rg2
  • product/154570
  • β-D-Glucopyranoside, (3β,6α,12β)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-
  • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol
  • (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
  • GINSENOSIDE Rg2 (S-FORM)
  • Ginsenoside Rg2-RM
  • Ginsenoside Rg2(P)
  • Ginsenoside Rg2, 10 mM in DMSO
  • 52286-74-5
  • 55086-74-5
  • 55286-74-5
  • C42H72O13
  • C40H68O14
  • Inhibitors
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Saponins
  • chemical reagent
  • Ginsenoside series