4-METHOXY-2-NITRO-BENZALDEHYDE
- Product Name
- 4-METHOXY-2-NITRO-BENZALDEHYDE
- CAS No.
- 22996-21-0
- Chemical Name
- 4-METHOXY-2-NITRO-BENZALDEHYDE
- Synonyms
- 4-Mehtyl-2-Nitro-Benzaldehyde;4-Methoxy-2-nitrobenzaL;4-METHOXY-2-NITRO-BENZALDEHYDE;Benzaldehyde, 4-methoxy-2-nitro-;4-METHOXY-2-NITRO-BENZALDEHYDE ISO 9001：2015 REACH;4-Formyl-3-nitroanisole, 2-Formyl-5-methoxynitrobenzene
- CBNumber
- CB1485239
- Molecular Formula
- C8H7NO4
- Formula Weight
- 181.15
- MOL File
- 22996-21-0.mol
4-METHOXY-2-NITRO-BENZALDEHYDE Property
- Melting point:
- 95.5-96 °C(Solv: chloroform (67-66-3); ligroine (8032-32-4))
- Boiling point:
- 354.7±27.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- color
- Yellow
- CAS DataBase Reference
- 22996-21-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M219348
- Product name
- 4-Methoxy-2-nitrobenzaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 072331
- Product name
- 4-Methoxy-2-nitrobenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- J55138
- Product name
- 4-Methoxy-2-nitrobenzaldehyde
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4654-1-W3
- Product name
- 4-Methoxy-2-nitrobenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 072331
- Product name
- 4-Methoxy-2-nitrobenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
4-METHOXY-2-NITRO-BENZALDEHYDE Chemical Properties,Usage,Production
Uses
4-Methoxy-2-nitrobenzaldehyde is soluble in both water and ethanol. Its uses include the study of enzyme inhibition and regulation of gene expression. As an inhibitor of drug-metabolizing enzymes, it binds to the active site of the enzyme and impedes its catalytic function. In addition, it is an important tool for studying the regulation of gene expression.
Synthesis
17484-36-5
22996-21-0
Example 4 Preparation of 3-[7-(1-methylpiperidin-4-yloxy)quinazolin-2-yl]aminobenzenesulfonamide Step 1. Preparation of 4-methoxy-2-nitrobenzaldehyde 4-Methyl-3-nitroanisole (20.43 g, 0.122 mol, 1.0 eq.) was dissolved in 480 mL of CCl4 under the protection of Ar atmosphere. N-bromosuccinimide (NBS, 48.94 g, 0.275 mol, 2.2 eq.) was added to the solution as a one-time addition, followed by benzoyl peroxide (0.67 g, 2.76 mmol). The reaction mixture was stirred under reflux conditions for 4.5 hours. An aliquot was analyzed by 1H NMR showing that about 90% of the starting material was converted to the dibromo derivative. The reaction mixture was cooled to room temperature and concentrated. The residual CCl4 was removed by azeotropic distillation with acetone twice. The residue was dissolved in acetone (1 L) and silver carbonate (Ag2CO3, 37.1 g, 0.135 mol, 1.1 equiv) and water (100 mL) were added. The reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by TLC (unfolding agent ratio: EtOAc:hexane = 3:7) and the formation of new spots was observed. The reaction mixture was filtered through a PP028218.0002 filter, the filter cake was washed with acetone and the filtrate was concentrated. To the crude product, 340 mL of water was added and the product was extracted with EtOAc (800 mL, 400 mL). The emulsion formed was filtered through diatomaceous earth to separate the organic and aqueous layers. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated to give 8.27 g of crude product. The crude product was purified by column chromatography (eluent: EtOAc/hexane) to give 14.7 g (67% yield) of the pure compound 4-methoxy-2-nitrobenzaldehyde.
References
[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 309-310
[2] Journal of the Chemical Society, 1949, p. Spl. 231
[3] Chemical and Pharmaceutical Bulletin, 1962, vol. 10, p. 856 - 865
[4] J. Gen. Chem. USSR (Engl. Transl.), 1960, vol. 30, p. 3091 - 3095
[5] Zhurnal Obshchei Khimii, 1960, vol. 30, # 9, p. 3118
4-METHOXY-2-NITRO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHOXY-2-NITRO-BENZALDEHYDE manufacturers
- Product
- 4-methoxy-2-nitrobenzaldehyde 22996-21-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 4-METHOXY-2-NITRO-BENZALDEHYDE 22996-21-0
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-24
- Product
- 4-Methoxy-2-nitrobenzaldehyde 22996-21-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-21