5-Methoxy-2-nitrobenzaldehyde

Product Name: 5-Methoxy-2-nitrobenzaldehyde
CAS No.: 20357-24-8
Chemical Name: 5-Methoxy-2-nitrobenzaldehyde
Synonyms: m-Anisaldehyde, 6-nitro-;2-NITRO-5-METHOXYBENZALDEHYDE;5-METHOXY-2-NITROBENZALDEHYDE;Benzaldehyde, 5-methoxy-2-nitro-;N-(3-bromo-7-fluoro-9H-fluoren-2-yl)acetamide;5-Methoxy-2-nitrobenzaldehyde ISO 9001：2015 REACH;2-Formyl-4-methoxynitrobenzene, 3-Formyl-4-nitroanisole
CBNumber: CB7335323
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 20357-24-8.mol

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5-Methoxy-2-nitrobenzaldehyde Property

Melting point:: 83 °C
Boiling point:: 354.7±27.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline solid
color: Yellow
InChI: InChI=1S/C8H7NO4/c1-13-7-2-3-8(9(11)12)6(4-7)5-10/h2-5H,1H3
InChIKey: BNTDDWPHSMILHQ-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(OC)=CC=C1[N+]([O-])=O
CAS DataBase Reference: 20357-24-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2912490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3593
Product name: 5-Methoxy-2-nitrobenzaldehyde
Purity: min. 98.0 %
Packaging: 1G
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: M3593
Product name: 5-Methoxy-2-nitrobenzaldehyde
Purity: min. 98.0 %
Packaging: 5G
Price: $135
Updated: 2025/07/31

TRC

Product number: M327058
Product name: 5-Methoxy-2-nitrobenzaldehyde
Packaging: 1g
Price: $70
Updated: 2021/12/16

Apolloscientific

Product number: OR14772
Product name: 5-Methoxy-2-nitrobenzaldehyde
Purity: 98%
Packaging: 1g
Price: $22
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-W5
Product name: 5-Methoxy-2-nitrobenzaldehyde
Packaging: 1g
Price: $24
Updated: 2021/12/16

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5-Methoxy-2-nitrobenzaldehyde Chemical Properties,Usage,Production

Uses

5-Methoxy-2-nitrobenzaldehyde is a starting material used to synthesize a novel class of cis-locked combretastatins named combretabenzodiazepines which shows cytotoxic and antitubulin activity.

Synthesis

42454-06-8

74-88-4

20357-24-8

Step 1. Synthesis of 5-methoxy-2-nitrobenzaldehyde: 5-hydroxy-2-nitrobenzaldehyde (1 eq.), iodomethane (1.1 eq.) and potassium carbonate (1 eq.) were dissolved in DMF at room temperature and the reaction was stirred for 16 hours. Upon completion of the reaction, the reaction mixture was concentrated and subsequently partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated to give 5-methoxy-2-nitrobenzaldehyde in quantitative yield. Mass spectrometry analysis showed the molecular ion peak [M+H]+ = 182.

References

[1] Patent: US2005/85482, 2005, A1. Location in patent: Page/Page column 13; 17
[2] Patent: WO2010/51031, 2010, A1. Location in patent: Page/Page column 45
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1678 - 1681
[4] Patent: CN107522766, 2017, A. Location in patent: Paragraph 0136; 0137; 0138
[5] Chemical Communications, 2011, vol. 47, # 42, p. 11683 - 11685

5-Methoxy-2-nitrobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Methoxy-2-nitrobenzaldehyde Suppliers

China 97 Germany 1 India 4 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 14 Global 124

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View Lastest Price from 5-Methoxy-2-nitrobenzaldehyde manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

Career Henan Chemical Co

Product: 5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

20357-24-8, 5-Methoxy-2-nitrobenzaldehydeRelated Search:

3,5-Dimethoxybenzaldehyde 2,6-Dimethoxybenzaldehyde 4-Nitrobenzaldehyde p-Anisaldehyde 2-Bromo-5-methoxybenzaldehyde Veratraldehyde (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde o-Anisaldehyde 4-Nitrobenzoic acid 3-(METHOXYMETHOXY)BENZALDEHYDE 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER 5-Methoxy-2-(trifluoroMethyl)benzaldehyde Nitrobenzene ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE 6-Nitroveratraldehyde Methyl 2-nitro-3,4,5-trimethoxybenzoate

5-METHOXY-2-NITROBENZALDEHYDE

2-NITRO-5-METHOXYBENZALDEHYDE

2-Formyl-4-methoxynitrobenzene, 3-Formyl-4-nitroanisole

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N-(3-bromo-7-fluoro-9H-fluoren-2-yl)acetamide

5-Methoxy-2-nitrobenzaldehyde ISO 9001：2015 REACH

20357-24-8