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CINALUKAST

Product Name
CINALUKAST
CAS No.
128312-51-6
Chemical Name
CINALUKAST
Synonyms
Ro 24-591;RO 24-5913;CINALUKAST;C·Nalukast;2,2-Diethyl-N-[3-[(E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]succinamidic acid;(E)-4-[[3-(2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL)PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID;4-[[3-[(1E)-2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL]PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID;Butanoic acid, 4-[[3-[(1E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]aMino]-2,2-diethyl-4-oxo-;Ro 24-5913, (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
CBNumber
CB1486281
Molecular Formula
C23H28N2O3S
Formula Weight
412.55
MOL File
128312-51-6.mol
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CINALUKAST Property

storage temp. 
2-8°C
solubility 
DMSO: >10 mg/mL
form 
Powder
color 
off-white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6239
Product name
Cinalukast
Purity
~98% (HPLC)
Packaging
5mg
Price
$149
Updated
2025/07/31
TRC
Product number
C441900
Product name
Cinalukast
Packaging
5mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20441
Product name
Cinalukast
Packaging
2mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20441
Product name
Cinalukast
Packaging
5mg
Price
$227.2
Updated
2021/12/16
ApexBio Technology
Product number
B6930
Product name
Cinalukast
Packaging
10mg
Price
$282
Updated
2021/12/16
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CINALUKAST Chemical Properties,Usage,Production

Uses

A novel leukotriene D4 antagonist.

Definition

ChEBI: 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in th human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.

Biological Activity

Potent, selective CysLT 1 (LTD 4 ) leukotriene receptor antagonist (IC 50 = 6.4 nM). Inhibits LTD 4 -induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.

in vivo

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1].

Animal Model:Guinea pigs[1]
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once
Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.

CINALUKAST Preparation Products And Raw materials

Raw materials

Preparation Products

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CINALUKAST Suppliers

Canada 1 China 31 Germany 1 Switzerland 1 United Kingdom 5 United States 11 Global 50
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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15838
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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China
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15402
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60
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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China
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12335
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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020-39119999
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isunpharm@qq.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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Chengdu Huachun Technology Co., Ltd
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400-1166-196 15982826727
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QQ：800101999
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cdhxsj@163.com
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China
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14603
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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57422
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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128312-51-6, CINALUKASTRelated Search:

lifitegrast Cilomilast MCI 826 CINALUKAST

  • (E)-4-[[3-(2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL)PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID
  • CINALUKAST
  • RO 24-5913
  • 4-[[3-[(1E)-2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL]PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID
  • Ro 24-591
  • Ro 24-5913, (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
  • 2,2-Diethyl-N-[3-[(E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]succinamidic acid
  • Butanoic acid, 4-[[3-[(1E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]aMino]-2,2-diethyl-4-oxo-
  • C·Nalukast
  • 128312-51-6
  • C23H28N2O3S
  • Intermediates & Fine Chemicals
  • Pharmaceuticals