CINALUKAST

Product Name: CINALUKAST
CAS No.: 128312-51-6
Chemical Name: CINALUKAST
Synonyms: Ro 24-591;RO 24-5913;CINALUKAST;C·Nalukast;2,2-Diethyl-N-[3-[(E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]succinamidic acid;(E)-4-[[3-(2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL)PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID;4-[[3-[(1E)-2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL]PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID;Butanoic acid, 4-[[3-[(1E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]aMino]-2,2-diethyl-4-oxo-;Ro 24-5913, (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
CBNumber: CB1486281
Molecular Formula: C23H28N2O3S
Formula Weight: 412.55
MOL File: 128312-51-6.mol

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CINALUKAST Property

storage temp.: 2-8°C
solubility: DMSO: >10 mg/mL
form: Powder
color: off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6239
Product name: Cinalukast
Purity: ~98% (HPLC)
Packaging: 5mg
Price: $203
Updated: 2024/03/01

TRC

Product number: C441900
Product name: Cinalukast
Packaging: 5mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20441
Product name: Cinalukast
Packaging: 2mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20441
Product name: Cinalukast
Packaging: 5mg
Price: $227.2
Updated: 2021/12/16

ApexBio Technology

Product number: B6930
Product name: Cinalukast
Packaging: 10mg
Price: $282
Updated: 2021/12/16

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CINALUKAST Chemical Properties,Usage,Production

Uses

A novel leukotriene D4 antagonist.

Definition

ChEBI: 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in th human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.

Biological Activity

Potent, selective CysLT 1 (LTD 4 ) leukotriene receptor antagonist (IC 50 = 6.4 nM). Inhibits LTD 4 -induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.

CINALUKAST Preparation Products And Raw materials

Raw materials

Preparation Products

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CINALUKAST Suppliers

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128312-51-6, CINALUKASTRelated Search:

lifitegrast Cilomilast MCI 826 CINALUKAST

(E)-4-[[3-(2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL)PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID

CINALUKAST

RO 24-5913

4-[[3-[(1E)-2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL]PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID

Ro 24-591

Ro 24-5913, (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid

2,2-Diethyl-N-[3-[(E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]succinamidic acid

Butanoic acid, 4-[[3-[(1E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]aMino]-2,2-diethyl-4-oxo-

C·Nalukast

128312-51-6

C23H28N2O3S

Intermediates & Fine Chemicals

Pharmaceuticals