ChemicalBook > CAS DataBase List > METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE

METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE

Product Name: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
CAS No.: 17449-76-2
Chemical Name: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
Synonyms: METHYL 4-HYDROXYCYCLOHEXANE-1-CARBOXYLATE;METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE;HYDROXYCYCLOHEXANECARBOXYLIC ACID METHYL ESTER;4-Hydroxycyclohexanecarboxylic acid methyl ester;Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester;METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE ISO 9001：2015 REACH;4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane
CBNumber: CB1490323
Molecular Formula: C8H14O3
Formula Weight: 158.2
MOL File: 17449-76-2.mol

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METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Property

Boiling point:: 233℃
Density: 1.121
Flash point:: 94℃
storage temp.: Sealed in dry,Room Temperature
pka: 14.96±0.40(Predicted)
form: liquid
color: Brown
InChI: InChI=1S/C8H14O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6-7,9H,2-5H2,1H3
InChIKey: HYDYVXROZHFTGB-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)CCC(O)CC1

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Safety

HS Code: 2902110000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M323648
Product name: Methyl4-Hydroxycyclohexanecarboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J57008
Product name: Methyl4-hydroxycyclohexanecarboxylate
Packaging: 5g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2229-1-X1
Product name: Methyl 4-hydroxycyclohexane-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $84
Updated: 2021/12/16

AK Scientific

Product number: W3805
Product name: Methyl4-hydroxycyclohexanecarboxylate
Packaging: 5g
Price: $101
Updated: 2021/12/16

AK Scientific

Product number: J57008
Product name: Methyl4-hydroxycyclohexanecarboxylate
Packaging: 10g
Price: $110
Updated: 2021/12/16

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METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

99-76-3

3618-03-9

Example 1: To a Parr high pressure reaction flask was added 150 mL of methanol followed by 25 g of methyl 4-hydroxybenzoate (nipagin methyl ester). After displacing the air in the reaction flask with nitrogen, 2.5 g of 5% rhodium/alumina catalyst was added. The reaction mixture was pressurized to 3.74 MPa under hydrogen atmosphere and the reaction was continuously shaken at room temperature for 18 hours. Upon completion of the reaction, the hydrogen was replaced with nitrogen and the reaction mixture was filtered through a diatomaceous earth pad to separate the catalyst. The diatomaceous earth pad was washed with methanol, taking care to avoid drying of the catalyst. The filtrate and washings were combined and concentrated under reduced pressure at 40 °C to remove methanol. The residue was dissolved in 200 mL of ether and 3 g of anhydrous potassium carbonate was added. The precipitated alumina and potassium carbonate were removed by diatomaceous earth filtration and washed with ether. The filtrates were combined and the solvent was removed under reduced pressure to give the crude product. The crude product was distilled by a Kugelrohr short-range distillation apparatus at 80-100 °C/1 mmHg to give 25.0 g (98% yield) of methyl 4-hydroxycyclohexanecarboxylate (cis-4-hydroxycyclohexanecarboxylic acid methyl ester). The product was characterized by 1H NMR (CDCl3, 60 MHz): δ 3.85 (s, 1H); 3.65 (s, 3H); 2.50-1.20 (m, 10H).

References

[1] Canadian Journal of Chemistry, 1982, vol. 60, p. 1996 - 2001
[2] Journal of Organic Chemistry, 1991, vol. 56, # 5, p. 1758 - 1763
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[4] Bulletin de la Societe Chimique de France, 1970, p. 556 - 562
[5] Bulletin de la Societe Chimique de France, 1969, p. 781 - 787

METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester 17449-76-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Pharmahands (Taizhou) Co., Ltd.

Product: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 17449-76-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg/month
Release date: 2020-10-30

Career Henan Chemical Co

Product: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 17449-76-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 697
Release date: 2019-09-01

17449-76-2, METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATERelated Search:

22(S),23(S)-HOMOBRASSINOLIDE ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Azadirachtin AZADIRACHTIN H(SH) ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Brassinolide Homobrassinolide 4-Hydroxycyclohexanecarboxylic acid 22S,23S-EPIBRASSINOLIDE trans-Methyl4-hydroxycyclohexanecarboxylate methyl 2-hydroxycyclohexanecarboxylate AKOS BB-2936 3,4-EPOXY-6-METHYLCYCLOHEXYLMETHYL-3,4-EPOXY-6-METHYLCYCLOHEXANECARBOXYLATE AKOS BC-1672 AKOS BB-2935 AKOS BC-1751 AKOS B024701 DIETHYL 2-(4-ETHOXYPHENYL)-4-HYDROXY-4-METHYL-6-OXOCYCLOHEXANE-1,3-DICARBOXYLATE

Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester

4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane

HYDROXYCYCLOHEXANECARBOXYLIC ACID METHYL ESTER

METHYL 4-HYDROXYCYCLOHEXANE-1-CARBOXYLATE

METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE

4-Hydroxycyclohexanecarboxylic acid methyl ester

METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE ISO 9001：2015 REACH

17449-76-2

pharmacetical

Esters

Ring Systems