ChemicalBook > CAS DataBase List > HELENALIN
HELENALIN
- Product Name
- HELENALIN
- CAS No.
- 6754-13-8
- Chemical Name
- HELENALIN
- Synonyms
- Helelin;NSC 85236;HELENALIN;CB1492352;HELENALIN(SH);HELENALIN USP/EP/BP;Helenalin (NSC 85236);a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- CBNumber
- CB1492352
- Molecular Formula
- C15H18O4
- Formula Weight
- 262.3
- MOL File
- 6754-13-8.mol
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HELENALIN Property
- Melting point:
- 167-168°
- alpha
- D25 -102.8° (c = 3.64 in 95% ethanol)
- Boiling point:
- 325.55°C (rough estimate)
- Density
- 1.0772 (rough estimate)
- refractive index
- 1.4300 (estimate)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
- form
- White to off-white solid.
- pka
- 13.29±0.60(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- LogP
- 0.870
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Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 6754-13-8(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): 150, 125 orally (Witzel)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 374000
- Product name
- Helenalin, A. chamissonis ssp. foliosa
- Packaging
- 500μG
- Price
- $617
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17050
- Product name
- Helenalin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $504
- Updated
- 2024/03/01
TRC
- Product number
- H230000
- Product name
- Helenalin
- Packaging
- 0.25mg
- Price
- $160
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0078850
- Product name
- Helenalin
- Purity
- 98.29%
- Packaging
- 500ug
- Price
- $270
- Updated
- 2021/12/16
Adipogen Life Sciences
- Product number
- AG-CN2-0435-M001
- Product name
- Helenalin
- Purity
- ≥96%(HPLC)
- Packaging
- 1mg
- Price
- $390
- Updated
- 2021/12/16
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HELENALIN Chemical Properties,Usage,Production
Description
Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1?and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.3 Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects.4
Uses
Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract.
Definition
ChEBI: Helenalin is a sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer). It has a role as an anti-inflammatory agent, an antineoplastic agent, a plant metabolite and a metabolite. It is a gamma-lactone, a cyclic ketone, an organic heterotricyclic compound, a sesquiterpene lactone and a secondary alcohol.
storage
+4°C
References
1) Lyss?et al. (1998),?The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65; J. Biol. Chem.,?273?33508 2) Lyss?et al. (1997),?Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB; Biol. Chem.,?278?951 3) Berges?et al. (2009),?Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms; Mol. Immunol.,?46?2892 4) Huang?et al. (2005),?Potent inhibition of human telomerase by helenalin; Cancer Lett.,?227?169
HELENALIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from HELENALIN manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- CB1492352 6754-13-8
- Price
- US $32.00-1.30/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28
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