ChemicalBook > CAS DataBase List > 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

Product Name
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
CAS No.
545380-34-5
Chemical Name
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
Synonyms
QNZ;CS-902;EVP4593;EVP-4593;EVP 4593;CAY10470;QNZ (EVP4593);CAY10470|||EVP4593;QNZ (EVP4593);EVP-4593;NF-κB Activation Inhibitor
CBNumber
CB7500822
Molecular Formula
C22H20N4O
Formula Weight
356.42
MOL File
545380-34-5.mol
More
Less

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Property

Melting point:
169-175°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0579
Product name
EVP4593
Purity
≥98% (HPLC)
Packaging
5mg
Price
$160
Updated
2024/03/01
Sigma-Aldrich
Product number
481406
Product name
NF-κB Activation Inhibitor
Packaging
1mg
Price
$144
Updated
2024/03/01
Alfa Aesar
Product number
J67487
Product name
QNZ, 98%
Packaging
1mg
Price
$68.3
Updated
2023/06/20
Alfa Aesar
Product number
J67487
Product name
QNZ, 98%
Packaging
0.5mg
Price
$25.4
Updated
2021/12/16
Cayman Chemical
Product number
10006734
Product name
QNZ
Purity
≥98%
Packaging
500μg
Price
$20
Updated
2024/03/01
More
Less

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Chemical Properties,Usage,Production

Description

QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50?= 11 nM) and TNF-α?production (IC50?= 7 nM).1,2?It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4?Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4?QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5?QNZ has also been identified as a potent (IC50?= 25 nM complex 1 from?Y.lipolytica; IC50?= 14 nM complex 1 from?Bos Taurus?heart mitochondria) and selective inhibitor of mitochondrial complex I.6?QNZ?decreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7

Chemical Properties

White Solid

Uses

QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m

Uses

QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.

target

NF-κB

References

1) Tobe?et al. (2003),?Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation; Bioorg. Med. Chem. Lett,?11?383 2) Tobe?et al.?(2003),?A novel structural class of potent inhibitors of NF-kB activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives; Bioorg. Med. Chem. Lett,?11?3869 3) Choi?et al.?(2006),?Nuclear factor-kappaB activated by capacitive Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells; J. Biol. Chem.,?281?12722 4) Wu?et al.?(2011),?Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington’s Disease Treatment; Chem. Biol.,?18?777 5) Wu?et al. (2016),?Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington’s Disease Mouse Model; J. Neurosci.,?36?125 6) Krishnathas?et al. (2017),?Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I; Medchemcomm.?8?657 7) Chernyuk?et al. (2019),?Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1?E9 mutant linked to familial Alzheimer disease;?Neuroscience,?410?118

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10007
Advantage
58
More
Less

View Lastest Price from 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI 545380-34-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29

545380-34-5, 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINERelated Search:


  • EVP4593; EVP 4593; EVP-4593
  • CS-902
  • NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem
  • QNZ
  • EVP 4593
  • EVP4593
  • EVP-4593
  • 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-
  • 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
  • N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine
  • QNZ (EVP4593)
  • QNZ (EVP4593);EVP-4593
  • N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine
  • NF-κB Activation Inhibitor
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLIN
  • CAY10470
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE USP/EP/BP
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI
  • N4- [2- (4-phenoxyphenyl) ethyl] -4,6-neneneba quinazoline diamine
  • CAY10470|||EVP4593
  • 545380-34-5
  • C22H20N4O
  • Inhibitors
  • Amines
  • Aromatics
  • Heterocycles
  • All Inhibitors
  • NF-kB