6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

ChemicalBook > CAS DataBase List > 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

Product Name: 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
CAS No.: 545380-34-5
Chemical Name: 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
Synonyms: QNZ;CS-902;EVP4593;EVP-4593;EVP 4593;CAY10470;QNZ (EVP4593);CAY10470|||EVP4593;QNZ (EVP4593);EVP-4593;NF-κB Activation Inhibitor
CBNumber: CB7500822
Molecular Formula: C22H20N4O
Formula Weight: 356.42
MOL File: 545380-34-5.mol

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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Property

Melting point:: 169-175°C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0579
Product name: EVP4593
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $160
Updated: 2024/03/01

Sigma-Aldrich

Product number: 481406
Product name: NF-κB Activation Inhibitor
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Alfa Aesar

Product number: J67487
Product name: QNZ, 98%
Packaging: 1mg
Price: $68.3
Updated: 2023/06/20

Alfa Aesar

Product number: J67487
Product name: QNZ, 98%
Packaging: 0.5mg
Price: $25.4
Updated: 2021/12/16

Cayman Chemical

Product number: 10006734
Product name: QNZ
Purity: ≥98%
Packaging: 500μg
Price: $20
Updated: 2024/03/01

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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Chemical Properties,Usage,Production

Description

QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50?= 11 nM) and TNF-α?production (IC50?= 7 nM).1,2?It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4?Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4?QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5?QNZ has also been identified as a potent (IC50?= 25 nM complex 1 from?Y.lipolytica; IC50?= 14 nM complex 1 from?Bos Taurus?heart mitochondria) and selective inhibitor of mitochondrial complex I.6?QNZ?decreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7

Chemical Properties

White Solid

Uses

QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m

Uses

QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.

target

NF-κB

References

1) Tobe?et al. (2003),?Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation; Bioorg. Med. Chem. Lett,?11?383 2) Tobe?et al.?(2003),?A novel structural class of potent inhibitors of NF-kB activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives; Bioorg. Med. Chem. Lett,?11?3869 3) Choi?et al.?(2006),?Nuclear factor-kappaB activated by capacitive Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells; J. Biol. Chem.,?281?12722 4) Wu?et al.?(2011),?Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington’s Disease Treatment; Chem. Biol.,?18?777 5) Wu?et al. (2016),?Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington’s Disease Mouse Model; J. Neurosci.,?36?125 6) Krishnathas?et al. (2017),?Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I; Medchemcomm.?8?657 7) Chernyuk?et al. (2019),?Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1?E9 mutant linked to familial Alzheimer disease;?Neuroscience,?410?118

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Suppliers

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View Lastest Price from 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI 545380-34-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

545380-34-5, 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINERelated Search:

HELENALIN 5-Aminosalicylic acid BAY 11-7085 IKK 16 MK-2206 2HCl 1,9-Pyrazoloanthrone Entinostat SB 203580 Olaparib Trimethoxypropylsilane BAY 11-7082 WITHAFERIN A ROCAGLAMIDE 3'-Hydroxyrocaglamide panepoxydone Rocaglamide I QNZ (EVP4593) N-(2-PHENYLETHYL)-4-QUINAZOLINAMINE

EVP4593; EVP 4593; EVP-4593

CS-902

NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

QNZ

EVP 4593

EVP4593

EVP-4593

4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-

4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine

N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine

QNZ (EVP4593)

QNZ (EVP4593);EVP-4593

N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine

NF-κB Activation Inhibitor

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLIN

CAY10470

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE USP/EP/BP

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI

N4- [2- (4-phenoxyphenyl) ethyl] -4,6-neneneba quinazoline diamine

CAY10470|||EVP4593

545380-34-5

C22H20N4O

Inhibitors

Amines

Aromatics

Heterocycles

All Inhibitors

NF-kB