6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
- Product Name
- 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
- CAS No.
- 545380-34-5
- Chemical Name
- 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
- Synonyms
- QNZ;CS-902;EVP4593;EVP-4593;EVP 4593;CAY10470;QNZ (EVP4593);CAY10470|||EVP4593;QNZ (EVP4593);EVP-4593;NF-κB Activation Inhibitor
- CBNumber
- CB7500822
- Molecular Formula
- C22H20N4O
- Formula Weight
- 356.42
- MOL File
- 545380-34-5.mol
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Property
- Melting point:
- 169-175°C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0579
- Product name
- EVP4593
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- 481406
- Product name
- NF-κB Activation Inhibitor
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- J67487
- Product name
- QNZ, 98%
- Packaging
- 1mg
- Price
- $68.3
- Updated
- 2023/06/20
- Product number
- J67487
- Product name
- QNZ, 98%
- Packaging
- 0.5mg
- Price
- $25.4
- Updated
- 2021/12/16
- Product number
- 10006734
- Product name
- QNZ
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $20
- Updated
- 2024/03/01
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Chemical Properties,Usage,Production
Description
QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50?= 11 nM) and TNF-α?production (IC50?= 7 nM).1,2?It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4?Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4?QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5?QNZ has also been identified as a potent (IC50?= 25 nM complex 1 from?Y.lipolytica; IC50?= 14 nM complex 1 from?Bos Taurus?heart mitochondria) and selective inhibitor of mitochondrial complex I.6?QNZ?decreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7
Chemical Properties
White Solid
Uses
QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m
Uses
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.
target
NF-κB
References
1) Tobe?et al. (2003),?Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation; Bioorg. Med. Chem. Lett,?11?383 2) Tobe?et al.?(2003),?A novel structural class of potent inhibitors of NF-kB activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives; Bioorg. Med. Chem. Lett,?11?3869 3) Choi?et al.?(2006),?Nuclear factor-kappaB activated by capacitive Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells; J. Biol. Chem.,?281?12722 4) Wu?et al.?(2011),?Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington’s Disease Treatment; Chem. Biol.,?18?777 5) Wu?et al. (2016),?Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington’s Disease Mouse Model; J. Neurosci.,?36?125 6) Krishnathas?et al. (2017),?Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I; Medchemcomm.?8?657 7) Chernyuk?et al. (2019),?Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1?E9 mutant linked to familial Alzheimer disease;?Neuroscience,?410?118
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE manufacturers
- Product
- 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI 545380-34-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29