BAY 11-7085
- Product Name
- BAY 11-7085
- CAS No.
- 196309-76-9
- Chemical Name
- BAY 11-7085
- Synonyms
- CS-1876;BAY 117083;BAY 11-7085;BAY117085;BAY11-7085;BAY 11-7085 USP/EP/BP;BAY 11-7085;BAY-11-7085;BAY 11-7083;BAY 11-7085 - CAS 196309-76-9 - Calbiochem;(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE
- CBNumber
- CB0675833
- Molecular Formula
- C13H15NO2S
- Formula Weight
- 249.33
- MOL File
- 196309-76-9.mol
BAY 11-7085 Property
- Melting point:
- 80-82℃
- Boiling point:
- 407.1±45.0 °C(Predicted)
- Density
- 1.144
- Flash point:
- 200℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: >25 mg/mL, soluble
- form
- solid
- color
- white
- Sensitive
- Light Sensitive
- InChIKey
- VHKZGNPOHPFPER-ONNFQVAWSA-N
- CAS DataBase Reference
- 196309-76-9
Safety
- WGK Germany
- 3
- RTECS
- UD1312500
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5681
- Product name
- Bay 11-7085
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- B4845
- Product name
- BAY 11-7085
- Purity
- >97.0%(N)
- Packaging
- 10mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- B4845
- Product name
- BAY 11-7085
- Purity
- >97.0%(N)
- Packaging
- 100mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- J67222
- Product name
- BAY 11-7085, 99%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2023/06/20
- Product number
- 14795
- Product name
- BAY 11-7085
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
BAY 11-7085 Chemical Properties,Usage,Production
Uses
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.
Uses
Bay 11-7085 has been used as:
- nuclear factor-κB inhibitor in Panc-1 cells, macrophages
- inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
- phospho-p65 inhibitor human monocyte cell line THP-1
Definition
ChEBI: BAY11-7085 is a sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB. It has a role as an anti-inflammatory agent, a ferroptosis inducer, a NF-kappaB inhibitor, an apoptosis inducer, an autophagy inducer, an antibacterial agent, an EC 2.7.11.10 (IkappaB kinase) inhibitor and an antineoplastic agent. It is a nitrile, a sulfone and a member of benzenes.
Biological Activity
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .
Biochem/physiol Actions
Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α
storage
Store at +4°C
References
[1]nasu k1, nishida m, ueda t, yuge a, takai n, narahara h. application of the nuclear factor-kappab inhibitor bay 11-7085 for the treatment of endometriosis: an in vitro study. am j physiol endocrinol metab. 2007 jul;293(1):e16-23
BAY 11-7085 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BAY 11-7085 manufacturers
- Product
- BAY 11-7085 196309-76-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30