BAY 11-7085

ChemicalBook > CAS DataBase List > BAY 11-7085

Product Name: BAY 11-7085
CAS No.: 196309-76-9
Chemical Name: BAY 11-7085
Synonyms: CS-1876;BAY 117083;BAY 11-7085;BAY117085;BAY11-7085;BAY 11-7085 USP/EP/BP;BAY 11-7085;BAY-11-7085;BAY 11-7083;BAY 11-7085 - CAS 196309-76-9 - Calbiochem;(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE
CBNumber: CB0675833
Molecular Formula: C13H15NO2S
Formula Weight: 249.33
MOL File: 196309-76-9.mol

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BAY 11-7085 Property

Melting point:: 80-82℃
Boiling point:: 407.1±45.0 °C(Predicted)
Density: 1.144
Flash point:: 200℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >25 mg/mL, soluble
form: solid
color: white
Sensitive: Light Sensitive
InChIKey: VHKZGNPOHPFPER-ONNFQVAWSA-N
CAS DataBase Reference: 196309-76-9

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Safety

WGK Germany: 3
RTECS: UD1312500
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B5681
Product name: Bay 11-7085
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $163
Updated: 2024/03/01

TCI Chemical

Product number: B4845
Product name: BAY 11-7085
Purity: >97.0%(N)
Packaging: 10mg
Price: $90
Updated: 2024/03/01

TCI Chemical

Product number: B4845
Product name: BAY 11-7085
Purity: >97.0%(N)
Packaging: 100mg
Price: $535
Updated: 2024/03/01

Alfa Aesar

Product number: J67222
Product name: BAY 11-7085, 99%
Packaging: 10mg
Price: $169
Updated: 2023/06/20

Cayman Chemical

Product number: 14795
Product name: BAY 11-7085
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

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BAY 11-7085 Chemical Properties,Usage,Production

Uses

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.

Uses

Bay 11-7085 has been used as:

nuclear factor-κB inhibitor in Panc-1 cells, macrophages
inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
phospho-p65 inhibitor human monocyte cell line THP-1

Definition

ChEBI: BAY11-7085 is a sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB. It has a role as an anti-inflammatory agent, a ferroptosis inducer, a NF-kappaB inhibitor, an apoptosis inducer, an autophagy inducer, an antibacterial agent, an EC 2.7.11.10 (IkappaB kinase) inhibitor and an antineoplastic agent. It is a nitrile, a sulfone and a member of benzenes.

Biological Activity

Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .

Biochem/physiol Actions

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α

storage

Store at +4°C

References

[1]nasu k1, nishida m, ueda t, yuge a, takai n, narahara h. application of the nuclear factor-kappab inhibitor bay 11-7085 for the treatment of endometriosis: an in vitro study. am j physiol endocrinol metab. 2007 jul;293(1):e16-23

BAY 11-7085 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY 11-7085 Suppliers

Americas 1 China 72 Europe 1 Germany 2 India 3 Japan 2 Switzerland 3 United Kingdom 2 United States 21 Global 107

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View Lastest Price from BAY 11-7085 manufacturers

Career Henan Chemical Co

Product: BAY 11-7085 196309-76-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

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BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE

BAY 11-7085 - CAS 196309-76-9 - Calbiochem

CS-1876

BAY117085;BAY11-7085

BAY 11-7085;BAY-11-7085;BAY 11-7083

(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE

(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE

BAY 11-7085

(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile

BAY 117083

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085

(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile

2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-

BAY 11-7085 USP/EP/BP

196309-76-9

C13H15O2NS

Gene Regulation and Expression

Gene Regulation

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Inhibitors

Cytokine signaling