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1,4-Butane sultone

Product Name
1,4-Butane sultone
CAS No.
1633-83-6
Chemical Name
1,4-Butane sultone
Synonyms
butanesultone;1,4-BUTANE SULTON;-Sultone;1,4-Butane;butanesulfone;1,4-Butane suL;JACS-1633-83-6;δ-Valerosultone;1,4-Butylsultone;1,4-BUTANESULPHONE
CBNumber
CB1497155
Molecular Formula
C4H8O3S
Formula Weight
136.17
MOL File
1633-83-6.mol
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1,4-Butane sultone Property

Melting point:
12-15 °C (lit.)
Boiling point:
>165 °C/25 mmHg (lit.)
Density 
1.331 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.464(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
54g/l (decomposition)
form 
Liquid
color 
Clear colorless to yellow
Water Solubility 
54 g/L (20 ºC) decomposes
Sensitive 
Moisture Sensitive
BRN 
110588
InChIKey
MHYFEEDKONKGEB-UHFFFAOYSA-N
CAS DataBase Reference
1633-83-6(CAS DataBase Reference)
EPA Substance Registry System
1,2-Oxathiane, 2,2-dioxide (1633-83-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-40-68-20/21/22
Safety Statements 
22-36/37-45-36
RIDADR 
2810
WGK Germany 
3
RTECS 
RP4300000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29349990
Hazardous Substances Data
1633-83-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B85501
Product name
1,4-Butane sultone
Purity
≥99%
Packaging
25g
Price
$62.7
Updated
2024/03/01
Sigma-Aldrich
Product number
B85501
Product name
1,4-Butane sultone
Purity
≥99%
Packaging
100g
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20665
Product name
1,4-Butane sultone
Purity
for synthesis
Packaging
50mL
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20665
Product name
1,4-Butane sultone
Purity
for synthesis
Packaging
250ML
Price
$342
Updated
2024/03/01
TCI Chemical
Product number
B0136
Product name
1,4-Butane sultone
Purity
>99.0%(GC)
Packaging
25g
Price
$67
Updated
2024/03/01
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1,4-Butane sultone Chemical Properties,Usage,Production

Description

1,4-Butane sultone is an impurity in sulfobutyl ether β-cyclodextrin (SBE-β-CD), and has been reported to be a weak carcinogen. 1,4-Butane sultone can be used for preparation of Br?nsted acidic ionic liquids and the ionic liquid is green, highly water soluble, thermally stable, specific and catalytically stable, and can be used for the preparation of symmetrical 3,3'-diaryloxyoctanone compounds[1-2].

Chemical Properties

Butanesultone is a viscous, clear, colourless – or yellowish/brown – and odourless liquid. When heated, vapours of butanesultone are known to form explosive mixtures with air and are reported to cause explosion hazards.

Uses

1,4-Butane Sultone is an alkylating agent with weak carcinogenic activity.

Uses

1,4-Butane sultone can be employed as a reactant in the preparation of conjugated polymers which include polybetaine, poly[2-ethynyl-N-(4-sulfobutyl)pyridinium betaine] (PESPB).
It can also be used in the preparation of Bronsted acid catalysts such as 4-(succinimido)-1-butane sulfonic acid and poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate. These catalysts facilitate the synthesis of 1-amidoalkyl-2-naphthols, substituted quinolines, and pyrano[4,3-b]pyran derivatives.

Application

1,4-Butane sultone is an intermediate widely used for sulfonated surfactants.It is also applied in photo development and electroplating.It is used as the Intermediate for the production of APIs.It used in sulfobutylether-β-cyclodextrin(SEBCD).

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. See also SULFONATES. When heated to decomposition it emits toxic fumes of SOx

Synthesis

Performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator;performing acidification after the reaction is finished;performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization;and finally refining to obtain a 1,4-butane sultone finished product.

References

[1] LAYLA A. TAIB; Mosadegh K. Introduction of novel br?nsted acidic ionic liquids with perchlorate counter-anion for one-pot synthesis of symmetric 3,3′-diaryloxindoles[J]. Research on Chemical Intermediates, 2021. DOI:10.1007/s11164-021-04419-5.
[2] MENG WANG. Determination of Low-ppm Levels of 1,4-Butane Sultone in Sulfobutyl Ether β-Cyclodextrin Using Liquid–Liquid Extraction and GC–MS[J]. Chromatographia, 2012. DOI:10.1007/s10337-012-2275-8.

1,4-Butane sultone Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Butane sultone Suppliers

Changshu Hopax Chemical Co., Ltd.
Tel
0512-52299299-131 17321661701
Email
zhurz@hopaxcs.com
Country
China
ProdList
30
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58
wuhan Bright Chemical Co.,Ltd
Tel
+86-027-85583407 +86-13554014698
Fax
+86-27-85804899
Email
purchase_peng@brightchemical.com.cn
Country
China
ProdList
63
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58
Hubei Changrun Biomedical Technology Co., Ltd.
Tel
027-63496417; 13667180236
Fax
13476107660
Email
3294393103@qq.com
Country
China
ProdList
305
Advantage
58
Wuhan Roche Technology Development Co., Ltd.,
Tel
18986168071
Fax
027-88121016
Email
18986168071@163.com
Country
China
ProdList
66
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55
Hubei Hongjing Chemical Co., Ltd.
Tel
027-82333386 13669024603
Fax
86-027-82333386
Email
617019505@qq.com
Country
China
ProdList
276
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58
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
2873
Advantage
58
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091 13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
10964
Advantage
58
Wuhan Xinzhongke Chemical Technology Co., Ltd
Tel
13628625909
Email
13628625909@163.com
Country
China
ProdList
2708
Advantage
58
Shandong Deju Renhe chemical raw materials Co., Ltd
Tel
15253208962
Email
sddjrhhgyl@126.com
Country
China
ProdList
663
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from 1,4-Butane sultone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
1,4-Butane sultone 1633-83-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-01
Hebei Guanlang Biotechnology Co., Ltd.
Product
1,4-Butane sultone 1633-83-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2023-02-25
Hebei Mojin Biotechnology Co., Ltd
Product
1,4-Butane sultone 1633-83-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-28

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