2-ACETYLBENZALDEHYDE 95

2-ACETYLBENZALDEHYDE 95 Property

Melting point:

39-43 °C (lit.)

Boiling point:

268.8±23.0 °C(Predicted)

Density 

1.117±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C, stored under nitrogen

form 

crystalline solid

color 

White/off-white

Safety

WGK Germany 

3

HS Code 

2914409000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-ACETYLBENZALDEHYDE 95 Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 2-acetylbenzaldehyde using 2-ethynylbenzaldehyde as starting material: the general method was as follows: first, AgBArF (97.1 mg, 0.1 mmol) was accurately weighed and placed in a long-necked glass reactor, followed by the addition of 2-ethynylbenzaldehyde (1 mmol). Next, 10 μL of ethyl acetate (EtOAc) was added and stirred for 5 min. After that, n-dodecane (1 mmol), an internal standard, and 3 mL of deionized water were added, and the reaction device was placed in an oil bath at 80 °C with continuous stirring and heated for 12 to 24 hours. Upon completion of the reaction, the reaction device was opened and 3 mL of ethyl acetate (EtOAc) was added to it and stirred for 5 minutes, after which the organic phase was separated and collected. The organic phase was passed through a short silica gel column to remove possible impurities and subsequently analyzed by GC-MS. Finally, the product was purified by silica gel column chromatography using a hexane/ethyl acetate (EtOAc) solvent mixture as eluent. The purified product was structurally characterized by 1H NMR and ESI-MS.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1444 - 1447