ChemicalBook > CAS DataBase List > MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)

Product Name: MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
CAS No.: 80047-24-1
Chemical Name: MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
Synonyms: Win 47338;Milrinone amide;Milrinone USP RC A;Milrinone Impurity Ⅰ;Milrinone Impurity G;Milrinone ImpuritiesA;Milrinone Related CoMpound A;Milrinone USP Related Compound A;6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyr;Milrinone amide (Milrinone impurity)
CBNumber: CB1500512
Molecular Formula: C12H11N3O2
Formula Weight: 229.23
MOL File: 80047-24-1.mol

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MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Property

Melting point:: >300 °C (decomp)
Boiling point:: 563.9±50.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Aqueous Acid (Very Slightly), DMSO (Very Slightly, Heated, Sonicated), Methanol
form: Solid
pka: 8.65±0.10(Predicted)
color: Pale Yellow
Stability:: Hygroscopic

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Safety

HS Code: 2933790002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1443919
Product name: Milrinone Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50MG
Price: $1250
Updated: 2025/07/31

TRC

Product number: D289445
Product name: 5-DescyanoMilrinone5-Carboxyamide
Packaging: 50mg
Price: $565
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0067033
Product name: 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $848.93
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-5M
Product name: 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide
Purity: 98.0%
Packaging: 250mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 9920AE
Product name: 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide
Packaging: 250mg
Price: $177
Updated: 2021/12/16

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MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Chemical Properties,Usage,Production

Uses

5-Descyano Milrinone 5-Carboxyamide (Milrinone USP Related Compound A) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

Synthesis

78415-72-2

80047-24-1

General procedure for the synthesis of 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carbonitrile from 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide: Concentrated sulfuric acid (350 μL, 6.3 mmol, 14 equiv) was added to 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2- dihydropyridine-3-carbonitrile (95 mg, 0.450 mmol, 1 eq.) The reaction mixture was heated to 120 °C and maintained for 15 min. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with water, followed by slow addition of concentrated ammonium hydroxide solution to adjust the pH to 10. The precipitate was collected by filtration and washed with an appropriate amount of water, and dried to afford the target product, 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide, as a white solid (74 mg, 72% yield).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 635 - 640
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 11, p. 3021 - 3029

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

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80047-24-1, MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)Related Search:

Milrinone Milrinone IMpurity 2 MILBEMECTIN A3 Miconazole EP Impurity E Milbemycin EP Impurity E Milrinone Impurity 14 Milrinone Impurity 17 5-Decyano 5-(Ethyl Formate) Milrinone Miconazole IMpurity I Miconazole IMpurity B 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxylic acid 1,6-Dihydro-2-(hydroxyMethyl)-6-oxo-[3,4'-bipyridine]-5-carbonitrile Milbemycin oxime Isoconazole Milbemycin EP Impurity D Milrinone Impurity 13 Miconazole Impurity Milrinone Impurity 18

Milrinone Impurit Ⅰ：1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carboxamide

Milrinone Impurity Ⅰ

Milrinone USP Related Compound A

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)

Milrinone amide (Milrinone impurity)

2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE

1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide

Milrinone amide

1,6-Dihydro-2-Methyl-6-oxo(3,4'-bipyridine)-5-carboxaMide

Milrinone Related CoMpound A

Milrinone USP RC A

Milrinone Impurity G

Milrinone Impurity Ⅰ（1,6-Dihydro-2-methyl-6-oxo-（3,4′-bipyridine）-5-carboxamide）

6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyr

[3,4'-Bipyridine]-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-

Milrinone ImpuritiesA

Milrinone Related Compound A (1,6-Dihydro-2-methyl-6-oxo(3,4''-bipyridine)-5-carboxamide) (1443919)

Milrinone Impurity Ⅰ (1,6-Dihydro-2-methyl-6-oxo- (3,4′-bipyridine) -5-carboxamide)

2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide

Milrinone impurity Ⅰ(1,6-dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-amide)

6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carboxamide

Win 47338

2-Methyl-6-oxo-1,6-dihydro-3,4′-bipyridine-5-carboxamide, CAS 80047-24-1

2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide , Milrinone Related Compound A

80047-24-1

Pyridines