ChemicalBook > CAS DataBase List > DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

Product Name
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
CAS No.
53016-31-2
Chemical Name
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
Synonyms
RWJ 10553;BRN 4202099;levonorgestreloxime;D-Norgestrel 3-oxime;(-)-NorelgestroMin-d6;Desacetylnorgestimate;17-Deacylnorgestimate;Levonorgestrel 3-oxime;Norgestimate Impurity C; 17-Deacetylnorgestimate
CBNumber
CB1500552
Molecular Formula
C21H29NO2
Formula Weight
327.46
MOL File
53016-31-2.mol
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DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Property

Melting point:
107-109°C
Boiling point:
491.9±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF: 11 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form 
A solid
pka
12.22±0.60(Predicted)
color 
White to off-white
CAS DataBase Reference
53016-31-2
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Safety

HS Code 
2937230000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1468454
Product name
Deacetylnorgestimate
Packaging
200mg
Price
$710
Updated
2024/03/01
Sigma-Aldrich
Product number
1471958
Product name
Deacetylnorgestimate
Packaging
25mg
Price
$1240
Updated
2022/05/15
TRC
Product number
D288721
Product name
(E/Z)-17-Deacetylnorgestimate
Packaging
250mg
Price
$1260
Updated
2021/12/16
ChemScene
Product number
CS-4097
Product name
NorgestimatemetaboliteNorelgestromin
Purity
99.79%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-4097
Product name
NorgestimatemetaboliteNorelgestromin
Purity
99.79%
Packaging
10mg
Price
$168
Updated
2021/12/16
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DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Chemical Properties,Usage,Production

Description

Ortho Evra@ is the first birth control transdermal patch and contains a combination of norelgestromin and ethinylestradiol. The patch can be applied to the buttocks, lower abdomen, upper torso or arms; changed weekly for 3 weeks, followed by a patch-free week. Norelgestromin is the active metabolite produced following oral administration of norgestimate, the progestin component of the contraceptive, Ortho-Cyclen?. The half-life value of norelgestromin was approximately 28 h. Following application, norelgestromin rapidly appeared in the serum, reached a plateau by approximately 48h and was maintained at an approximate steady state throughout the wear period. Hepatic metabolites of norelgestromin included norgestrel and various hydroxylated and conjugated metabolites that were eliminated by renal and fecal pathways. Ortho Evra produced ovarian suppression and cycle control. It was significantly more effective in suppressing follicular development than the leading oral contraceptive Triphasil? (ethinyl estradiol/levomorgestrel); was as effective in preventing pregnancies and had similar tolerability profile. The patch offers 99% efficacy when used appropriately, as shown by three clinical trials. However, a statistically significantly greater proportion of pregnancies occurred among women weighing 90 kg or more. Ortho Evra? was well tolerated, with 2.6% of women discontinuing treatment due to mild to moderate reactions at the site of application. Thus, the patch combined the efficacy of oral contraceptives with the convenience of just once-weekly dosing.

Chemical Properties

White Solid

Originator

Johnson & Johnson (USA)

Uses

E/Z-17-Deacetylnorgestimate is a metabolite of Norgestimate. A contraceptive for birth control used by women.

Definition

ChEBI: Norelgestromin is a steroid. It derives from a hydride of an estrane.

brand name

ORTHOEVRA (R. W. Johnson); EVRA (R. W. Johnson) Note— Norelgestromin has appeared in the literature as 17- deacylnorgestimate.

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Preparation Products And Raw materials

Raw materials

Preparation Products

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53016-31-2, DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)Related Search:

Megestrol D(+)-Glucose 4-tert-Butyltoluene Sofalcone 4'-tert-Butylacetophenone Emamectin DICHLOFLUANID Hydroxyprogesterone acetate Levonorgestrel Norgestimate Norgestrel DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

  • (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one OxiMe
  • (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one-d6 OxiMe
  • (-)-NorelgestroMin-d6
  • (17alpha)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime
  • (E)- and (Z)-17-Deacetylnorgestimate mixture
  • Norgestimate metabolite Norelgestromin
  • 17-Desacetyl Norgestimate ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
  • Deacetylnorgestimate (Mixture of (E)- And (Z)-17-Deacetyl Norgestimate)
  • 17-Desacetyl Norgestimate Solution, 100ppm
  • (17R)-13-Ethyl-17-hydroxy-18,19-dinor-pregna-4-ene-20-yne-3-oneoxime
  • [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
  • [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregna-4-ene-20-yne-3-oneoxime
  • Desacetylnorgestimate
  • DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
  • ,10-alpha,13-alpha,14-beta)-
  • 18,19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,oxime,(8-alpha,9-beta
  • levonorgestreloxime
  • 17-Deacetylnorgestimate
  • (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Oxime
  • 18-Methylnorethindrone oxime
  • BRN 4202099
  • D-Norgestrel 3-oxime
  • Levonorgestrel 3-oxime
  • RWJ 10553
  • 13-ETHYL-17_-HYDROXY-18,19-DINORPREGN-4-EN-20-YN-3-ONE OXIME
  • 17-Desacetyl Norgestimate (Mixture of Isomers)
  • 17-Deacylnorgestimate
  • 17-Desacetyl Norgestimate-d7 (Mixture ofIsomers) (Norelgestromin-d7)
  • 17-Desacetyl Norgestimate (Mixture of Isomers) (Norelgestromin)
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, oxime, (17α)-
  • (E/Z)-17-Deacetylnorgestimate
  • 17-Desacetyl NorgestimateQ: What is 17-Desacetyl Norgestimate Q: What is the CAS Number of 17-Desacetyl Norgestimate Q: What is the storage condition of 17-Desacetyl Norgestimate Q: What are the applications of 17-Desacetyl Norgestimate
  • Norelgestromin (1468454)
  • Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) (1471958)
  • Deacetylnorgestimate (Mixture of (E)- And (Z))
  • Drug Metabolite,inhibit,Inhibitor,Norgestimate metabolite Norelgestromin
  • Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture)
  • (8R,9S,10R,13S,14S,17R,E)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime
  • Norgestimate Impurity C
  • Deacetylnorgestimate (25 mg) ((E)- and (Z)-17-deacetyl norgestimate mixture) (PLANNED TO BE DISCONTINUED)
  • Norgestimate metabolite Norelgestromin (mixture of isomers)
  • 53016-31-2
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids