PHENAMIL METHANESULFONATE

Product Name: PHENAMIL METHANESULFONATE
CAS No.: 1161-94-0
Chemical Name: PHENAMIL METHANESULFONATE
Synonyms: MHPIZTURFVSLTJ-UHFFFAOYSA-N;2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-, methanesulfonate (1:1)
CBNumber: CB1502107
Molecular Formula: C13H16ClN7O4S
Formula Weight: 401.8
MOL File: 1161-94-0.mol

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PHENAMIL METHANESULFONATE Property

storage temp.: 2-8°C
solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL
form: solid
color: yellow
CAS DataBase Reference: 1161-94-0

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P203
Product name: Phenamil methanesulfonate salt
Purity: solid
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: P203
Product name: Phenamil methanesulfonate salt
Purity: solid
Packaging: 25mg
Price: $177.6
Updated: 2024/03/01

Cayman Chemical

Product number: 14308
Product name: Phenamil (methanesulfonate)
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14308
Product name: Phenamil (methanesulfonate)
Purity: ≥98%
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 14308
Product name: Phenamil (methanesulfonate)
Purity: ≥98%
Packaging: 50mg
Price: $357
Updated: 2024/03/01

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PHENAMIL METHANESULFONATE Chemical Properties,Usage,Production

Chemical Properties

off-white to yellow solid

Uses

Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte

Uses

Phenamil methanesulfonate salt has been used:

to stimulate adipocyte differentiation in 3T3 cells
to test its effect on lateral flagella expression in Vibrio shilonii
in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

General Description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

storage

Store at +4°C

PHENAMIL METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PHENAMIL METHANESULFONATE Suppliers

China 15 India 1 United Kingdom 1 United States 9 USA 1 Global 27

J & K SCIENTIFIC LTD.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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1161-94-0, PHENAMIL METHANESULFONATERelated Search:

PHENAMIL METHANESULFONATE 2-Amino-5-chloropyrazine PHENAMIL 5-AMINOPYRAZINE-2-CARBOXAMIDE 2-pyrazinoylguanidine 6-CHLORO-2-PYRAZINECARBOXAMIDE 2-amino-3-chloro-5-methyl-pyrazine 5-(N,N-HEXAMETHYLENE)-AMILORIDE 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 2,6-Pyrazinediamine(9CI) 3-AMINO-6-CHLOROPYRAZINE-2-CARBALDEHYDE

MHPIZTURFVSLTJ-UHFFFAOYSA-N

2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-, methanesulfonate (1:1)

1161-94-0

Amines, Aromatics, Sulfur & Selenium Compounds