METHYL 3-NITROPROPIONATE 97

METHYL 3-NITROPROPIONATE 97 Property

Boiling point:

68 °C/1 mmHg(lit.)

Density 

1.249 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4350(lit.)

Flash point:

110 °C

pka

7.67±0.29(Predicted)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

METHYL 3-NITROPROPIONATE 97 Chemical Properties,Usage,Production

Uses

Methyl 3-Nitropropanoate is used to nitroaldol additions, condensation reactions, and Michael additions involving the NO2-substituted carbon; the α-carbonyl carbon in dilithionitronate enolates of the esters undergoes alkylations, double alkylations, and aldol and Michael additions; elimination of HNO2 from the products gives α,β- unsaturated esters with substituents in either the β- or the α-position, thus making the reagent a synthetic equivalent of acrylate anions with d3 or d2 reactivity; precursor to nitrile oxide for [3 + 2] cycloadditions; 3-nitropropanoyl chloride can be used for enolate acylation and five-membered ring annulation.