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3-NITROPROPIONIC ACID

Product Name
3-NITROPROPIONIC ACID
CAS No.
504-88-1
Chemical Name
3-NITROPROPIONIC ACID
Synonyms
3-NP;bovinocidin;NSC 64266;3-NP acid;nci-c03076;hiptagenicacid;3-nitropropanoate;3-nitropropanoicaci;3-nitro-propionicaci;3-nitropropanoicacid
CBNumber
CB4368089
Molecular Formula
C3H5NO4
Formula Weight
119.08
MOL File
504-88-1.mol
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3-NITROPROPIONIC ACID Property

Melting point:
68-70 °C (lit.)
Boiling point:
222.3°C (rough estimate)
Density 
1.6731 (rough estimate)
refractive index 
1.4940 (estimate)
storage temp. 
2-8°C
solubility 
alcohol: 100 mg/mL, may be light yellow
form 
powder or crystals
pka
3.66±0.10(Predicted)
color 
white to light yellow
BRN 
1759889
Stability:
Stable. Incompatible with strong oxidizing agents, bases, reducing agents.
EPA Substance Registry System
3-Nitropropanoic acid (504-88-1)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
UF6220000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
504-88-1(Hazardous Substances Data)
Toxicity
mmo-sat 100 mg/plate IAPUDO 27,283,80
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5636
Product name
3-Nitropropionic acid
Purity
≥97%
Packaging
1g
Price
$102
Updated
2024/03/01
Sigma-Aldrich
Product number
164603
Product name
3-Nitropropionic acid
Packaging
50mg
Price
$85.2
Updated
2024/03/01
Cayman Chemical
Product number
14684
Product name
3-Nitropropionic Acid
Purity
≥95%
Packaging
1g
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14684
Product name
3-Nitropropionic Acid
Purity
≥95%
Packaging
5g
Price
$270
Updated
2024/03/01
Sigma-Aldrich
Product number
N5636
Product name
3-Nitropropionic acid
Purity
≥97%
Packaging
10g
Price
$612
Updated
2024/03/01
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3-NITROPROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

gold crystalline solid

Uses

antineoplastic

Uses

3-Nitropropionic acid has been used:

  • to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
  • to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
  • as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Definition

ChEBI: 3-nitropropanoic acid is a C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. It has a role as a neurotoxin, an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor, an antimycobacterial drug and a mycotoxin. It is functionally related to a propionic acid. It is a conjugate acid of a 3-nitropropanoate. It is a tautomer of a 3-aci-nitropropanoic acid.

General Description

Golden crystals (from chloroform).

Air & Water Reactions

Water soluble.

Reactivity Profile

3-NITROPROPIONIC ACID is incompatible with bases, oxidizing agents and reducing agents.

Fire Hazard

Flash point data for 3-NITROPROPIONIC ACID are not available; however, 3-NITROPROPIONIC ACID is probably combustible.

Biological Activity

3-nitropropionic acid is an irreversible inhibitor of mitochondrial respiratory complex ii (succinate dehydrogenase), which impairs cellular energy metabolism by inhibiting succinate dehydrogenase and reducing atp production. also, 3-nitropropionic acid can cause the generation and release of reactive oxygen species (ros) from mitochondria (the main source of cellular oxidative stress), mitochondrial dna damage, as well as loss of mitochondrial function.1. huang ls, sun g, cobessi d, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex ii, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. journal of biological chemistry, 2006, 281(9): 5965-5972.2. zhang jq, shen m, zhu cc, et al. 3-nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse. plos one, 2014, 9(2): e86589.3. mandavilli bs, boldogh i, van houten b. 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial dna damage, and cell death are attenuated by bcl-2 overexpression in pc12 cells. brain research. molecular brain research, 2005, 133(2): 215-223.

Biochem/physiol Actions

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Safety Profile

Poison by intravenous andintraperitoneal routes. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.

3-NITROPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-NITROPROPIONIC ACID Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
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57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
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Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
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Sphinx Scientific Laboratory (Tianjin) Co., Ltd.
Tel
022-66211289-843 13672102692
Fax
QQ:2377893365
Email
contact@sphinxpharm.com
Country
China
ProdList
361
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
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View Lastest Price from 3-NITROPROPIONIC ACID manufacturers

Career Henan Chemical Co
Product
3-NITROPROPIONIC ACID 504-88-1
Price
US $8.00/KG
Min. Order
1KG
Purity
>98% HPLC
Supply Ability
20 tons
Release date
2020-02-17

504-88-1, 3-NITROPROPIONIC ACIDRelated Search:


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