MYOSEVERIN

Product Name: MYOSEVERIN
CAS No.: 267402-71-1
Chemical Name: MYOSEVERIN
Synonyms: Myoseverin>Myoseverin - CAS 267402-71-1 - Calbiochem;9-Isopropyl-2,6-bis(4-methoxybenzylamino)purine;9H-Purine-2,6-diamine, N2,N6-bis[(4-methoxyphenyl)methyl]-9-(1-methylethyl)-;Myoseverin,Microtubule/Tubulin,fragments,regeneration,tissue,inhibit,mononucleated,wound,Inhibitor,healing,microtubules,purine
CBNumber: CB1503836
Molecular Formula: C24H28N6O2
Formula Weight: 432.52
MOL File: 267402-71-1.mol

More

Less

MYOSEVERIN Property

Melting point:: 106.0 to 110.0 °C
Boiling point:: 661.3±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: chloroform: 50 mg/mL, soluble
form: solid
pka: 4.65±0.30(Predicted)
color: off-white
CAS DataBase Reference: 267402-71-1

More

Less

Safety

WGK Germany: 3
HS Code: 2933.99.8290

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: M2373
Product name: Myoseverin
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 14642
Product name: Myoseverin
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 14642
Product name: Myoseverin
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 14642
Product name: Myoseverin
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

TRC

Product number: M885100
Product name: Myoseverin
Packaging: 1mg
Price: $45
Updated: 2021/12/16

More

Less

MYOSEVERIN Chemical Properties,Usage,Production

Uses

Myoseverin is a microtubule interfering agent resulting in adverse cellular function. It affects a variety of growth factor, immunomodulatory, extracellular matrix remodelling and stress-response genes. This activity is consistent with the activation of pathways involving tissue regeneration and healing.

Biological Activity

myoseverin is a novel microtubule-binding molecule.microtubules are dynamic filamentous cytoskeletal proteins, which are composed of tubulin and are an critical therapeutic target in tumour cells. drugs binding to microtubules have been the first-line standard of anticancer therapy for decades and until the advent of targeted therapy.

in vitro

myoseverin was found to be able to induce the reversible fission of multinucleated myotubes into mononucleated fragments. in addition, cell proliferation and myotube fission promoted dna synthesis after myoseverin removal and transfer of the cells to the fresh growth medium. moreover, the biochemical analysis and transcriptional profiling showed that myoseverin alone did not reverse the processes of biochemical differentiation. however, myoseverin could affect the expression of various growth factor, extracellular matrix-remodeling, immunomodulatory, as well as stress response genes, which was consistent with the activation of pathways involved in tissue regeneration and wound healing [1]. another study found that myoseverin-treated cardiac myocytes showed disruptions of the striated z-bands with alpha-actinin and desmin. similarly, active stathmin expression did not prevent the assembly of sarcomere. moreover, the extent of mt destabilization caused by myoseverin and nocodazole were comparable [2].

IC 50

16 nm

References

[1] rosania gr,chang yt,perez o,sutherlin d,dong h,lockhart dj,schultz pg. myoseverin, a microtubule-binding molecule with novel cellular effects. nat biotechnol.2000 mar;18(3):304-8.
[2] ng dc,gebski bl,grounds md,bogoyevitch ma. myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. cell motil cytoskeleton.2008 jan;65(1):40-58.

MYOSEVERIN Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MYOSEVERIN Suppliers

Americas 1 China 35 Europe 1 India 1 Japan 1 Switzerland 1 The Netherlands 1 United States 8 USA 1 Global 50

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4601
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15084
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 6884
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9995
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002
Email: zhejia01@163.com
Country: China
ProdList: 8870
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

Guangdong Shengke Biochemical Technology Co., Ltd.

Tel: 189-25112307 18925113981
Email: 3809205144@qq.com
Country: China
ProdList: 10000
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32957
Advantage: 60

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Shize Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shizezjp@163.com
Country: CHINA
ProdList: 6174
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

267402-71-1, MYOSEVERINRelated Search:

ACTIN FROM RABBIT MUSCLE MYOGLOBIN FROM HORSE SKELETAL MUSCLE* Vincristine sulfate ANSAMITOCIN P-3 TN-16 DOLASTATIN 15 NOCODAZOLE N-[(4-methoxyphenyl)methyl]pyrimidin-2-amine MYOSEVERIN 2,6-BIS(4-METHOXYBENZYLAMINO)-9-CYCLOHEXYLPURINE

Myoseverin - CAS 267402-71-1 - Calbiochem

Myoseverin&gt

9H-Purine-2,6-diamine, N2,N6-bis[(4-methoxyphenyl)methyl]-9-(1-methylethyl)-

9-Isopropyl-2,6-bis(4-methoxybenzylamino)purine

Myoseverin,Microtubule/Tubulin,fragments,regeneration,tissue,inhibit,mononucleated,wound,Inhibitor,healing,microtubules,purine

267402-71-1