MYOSEVERIN
- Product Name
- MYOSEVERIN
- CAS No.
- 267402-71-1
- Chemical Name
- MYOSEVERIN
- Synonyms
- Myoseverin>Myoseverin - CAS 267402-71-1 - Calbiochem;9-Isopropyl-2,6-bis(4-methoxybenzylamino)purine;9H-Purine-2,6-diamine, N2,N6-bis[(4-methoxyphenyl)methyl]-9-(1-methylethyl)-;Myoseverin,Microtubule/Tubulin,fragments,regeneration,tissue,inhibit,mononucleated,wound,Inhibitor,healing,microtubules,purine
- CBNumber
- CB1503836
- Molecular Formula
- C24H28N6O2
- Formula Weight
- 432.52
- MOL File
- 267402-71-1.mol
MYOSEVERIN Property
- Melting point:
- 106.0 to 110.0 °C
- Boiling point:
- 661.3±65.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- chloroform: 50 mg/mL, soluble
- form
- solid
- pka
- 4.65±0.30(Predicted)
- color
- off-white
- CAS DataBase Reference
- 267402-71-1
Safety
- WGK Germany
- 3
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M2373
- Product name
- Myoseverin
- Purity
- >98.0%(HPLC)
- Packaging
- 10mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 14642
- Product name
- Myoseverin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 14642
- Product name
- Myoseverin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 14642
- Product name
- Myoseverin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- M885100
- Product name
- Myoseverin
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
MYOSEVERIN Chemical Properties,Usage,Production
Uses
Myoseverin is a microtubule interfering agent resulting in adverse cellular function. It affects a variety of growth factor, immunomodulatory, extracellular matrix remodelling and stress-response genes. This activity is consistent with the activation of pathways involving tissue regeneration and healing.
Biological Activity
myoseverin is a novel microtubule-binding molecule.microtubules are dynamic filamentous cytoskeletal proteins, which are composed of tubulin and are an critical therapeutic target in tumour cells. drugs binding to microtubules have been the first-line standard of anticancer therapy for decades and until the advent of targeted therapy.
in vitro
myoseverin was found to be able to induce the reversible fission of multinucleated myotubes into mononucleated fragments. in addition, cell proliferation and myotube fission promoted dna synthesis after myoseverin removal and transfer of the cells to the fresh growth medium. moreover, the biochemical analysis and transcriptional profiling showed that myoseverin alone did not reverse the processes of biochemical differentiation. however, myoseverin could affect the expression of various growth factor, extracellular matrix-remodeling, immunomodulatory, as well as stress response genes, which was consistent with the activation of pathways involved in tissue regeneration and wound healing [1]. another study found that myoseverin-treated cardiac myocytes showed disruptions of the striated z-bands with alpha-actinin and desmin. similarly, active stathmin expression did not prevent the assembly of sarcomere. moreover, the extent of mt destabilization caused by myoseverin and nocodazole were comparable [2].
IC 50
16 nm
References
[1] rosania gr,chang yt,perez o,sutherlin d,dong h,lockhart dj,schultz pg. myoseverin, a microtubule-binding molecule with novel cellular effects. nat biotechnol.2000 mar;18(3):304-8.
[2] ng dc,gebski bl,grounds md,bogoyevitch ma. myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. cell motil cytoskeleton.2008 jan;65(1):40-58.
MYOSEVERIN Preparation Products And Raw materials
Raw materials
Preparation Products
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