1-ETHYNYL-3 5-DIMETHOXYBENZENE 98

Product Name: 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98
CAS No.: 171290-52-1
Chemical Name: 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98
Synonyms: Bexagliflozin Impurity 15;ethynyl-3,5-dimethoxybenzene;1-Ethylnyl-3,5-dimethoxybenzene;-ETHYNYL-3 5-DIMETHOXYBENZENE 98;Benzene, 1-ethynyl-3,5-diMethoxy-;1-ETHYNYL-3 5-DIMETHOXYBENZENE 98;3,5-Dimethoxyphenylacetylene - [D52432];1-Ethynyl-3,5-diMethoxybenzene 98% (CP)
CBNumber: CB1505153
Molecular Formula: C10H10O2
Formula Weight: 162.19
MOL File: 171290-52-1.mol

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1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 Property

Melting point:: 44-48 °C (lit.)
Boiling point:: 264.1±30.0℃ (760 Torr)
Density: 1.06±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Orange to Green
InChI: InChI=1S/C10H10O2/c1-4-8-5-9(11-2)7-10(6-8)12-3/h1,5-7H,2-3H3
InChIKey: HUSBBWQIJMRKLI-UHFFFAOYSA-N
SMILES: C1(C#C)=CC(OC)=CC(OC)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 36-42/43
Safety Statements: 22-26-36/37-45
WGK Germany: 3
HS Code: 2909309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 588520
Product name: 1-Ethynyl-3,5-dimethoxybenzene
Purity: 98% (CP)
Packaging: 1g
Price: $99.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 588520
Product name: 1-Ethynyl-3,5-dimethoxybenzene
Purity: 98% (CP)
Packaging: 5g
Price: $657
Updated: 2023/06/20

TCI Chemical

Product number: E1175
Product name: 1-Ethynyl-3,5-dimethoxybenzene
Purity: >98.0%(GC)
Packaging: 200mg
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: E1175
Product name: 1-Ethynyl-3,5-dimethoxybenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $192
Updated: 2025/07/31

TRC

Product number: D481213
Product name: 3,5-Dimethoxyphenylacetylene
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 Chemical Properties,Usage,Production

Description

1-ethynyl-3,5-dimethoxybenzene is an organic reagent. Its benzene ring structure contains one acetylene group and two methoxy groups respectively, which are key structures for the synthesis of other heterocyclic compounds.

Synthesis

205746-51-6

171290-52-1

Under argon protection, 1-(2,2-dibromovinyl)-3,5-dimethoxybenzene (2.99 g, 9.28 mmol, 1 eq.) was dissolved in anhydrous tetrahydrofuran (50 mL) and stirred at -50 °C (dry ice/acetonitrile bath). Slowly n-butyllithium (24.0 mL, 1.6 M hexane solution, 38.4 mmol, 4.1 eq.) was added dropwise and the progress of the reaction was monitored by thin-layer chromatography (TLC) until the reaction was complete. The reaction mixture was quenched with saturated aqueous ammonium chloride solution (40 mL) and subsequently extracted with dichloromethane (3 x 20 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give an orange-brown oil (1.61 g). Purification by fast column chromatography (eluent: pure pentane followed by 19:1 pentane:ether) afforded a colorless crystalline solid 3,5-dimethoxyphenylacetylene (1.22 g, 81% yield) with Rf = 0.24 (pentane) and a melting point of 205 °C. The NMR hydrogen spectrum (400 °F) of 3,5-dimethoxyphenylacetylene was obtained as follows. Its NMR hydrogen spectrum (400.1 MHz, CDCl3) data were as follows: δ 6.72 (d, J = 2.3 Hz, 2H, ArH), 6.50 (t, J = 2.3 Hz, 1H, ArH), 3.76 (s, 6H, OCH3), 3.15 (s, 1H, C≡CH). The NMR carbon spectrum (100.6 MHz, CDCl3) data are as follows: δ 160.6 (C), 123.4 (C), 110.0 (CH), 102.3 (CH), 83.7 (C), 76.9 (CH), 55.4 (CH3).

References

[1] Tetrahedron Letters, 2009, vol. 50, # 17, p. 1969 - 1972
[2] Chemistry Letters, 2008, vol. 37, # 2, p. 174 - 175
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 273 - 279
[4] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2386 - 2396
[5] Tetrahedron, 2017, vol. 73, # 33, p. 5023 - 5028

1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 Suppliers

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View Lastest Price from 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 171290-52-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Ethynyl-3,5-dimethoxybenzene 171290-52-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98 171290-52-1
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

171290-52-1, 1-ETHYNYL-3 5-DIMETHOXYBENZENE 98Related Search:

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1-ETHYNYL-3 5-DIMETHOXYBENZENE 98

1-Ethylnyl-3,5-dimethoxybenzene

Benzene, 1-ethynyl-3,5-diMethoxy-

1-Ethynyl-3,5-diMethoxybenzene 98% (CP)

-ETHYNYL-3 5-DIMETHOXYBENZENE 98

ethynyl-3,5-dimethoxybenzene

Bexagliflozin Impurity 15

3,5-Dimethoxyphenylacetylene - [D52432]

171290-52-1

CH8801CC6H3OCH32

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