WEDELOLACTONE
- Product Name
- WEDELOLACTONE
- CAS No.
- 524-12-9
- Chemical Name
- WEDELOLACTONE
- Synonyms
- Wedelolactone;Wedelia lactone;Wedelolactone-RM;Wedelolactone CRS;Wedelolactone, ≥98%(HPLC);IKK Inhibitor II, Wedelolactone;5,11,12-Trihydroxy-7-MethoxycouMestan;Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.;1,8,9-trihydroxy-3-Methoxy-6H-benzofuro[3,2-c]chroMen-6-one;IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem
- CBNumber
- CB1505300
- Molecular Formula
- C16H10O7
- Formula Weight
- 314.25
- MOL File
- 524-12-9.mol
WEDELOLACTONE Property
- Melting point:
- 327～330℃
- Boiling point:
- 498.4±45.0 °C(Predicted)
- Density
- 1.655±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 14 mg/mL, soluble
- form
- solid
- pka
- 6.90±0.20(Predicted)
- color
- brown-beige
- InChIKey
- XQDCKJKKMFWXGB-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- W4016
- Product name
- Wedelolactone
- Purity
- ≥98% (HPLC), powder
- Packaging
- 1mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- W0015
- Product name
- Wedelolactone
- Packaging
- 1MG
- Price
- $117
- Updated
- 2024/03/01
- Product number
- W0015
- Product name
- Wedelolactone
- Packaging
- 10MG
- Price
- $525
- Updated
- 2024/03/01
- Product number
- 11796
- Product name
- Wedelolactone
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 11796
- Product name
- Wedelolactone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $82
- Updated
- 2024/03/01
WEDELOLACTONE Chemical Properties,Usage,Production
Uses
Wedelolactone is inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.
Definition
ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Biological Activity
wedelolactone is an inhibitor of ikk.ikb kinase (ikk) complex contains the catalytic subunits ikkα and ikkβ, and the regulatory subunit ikkγ/nemo. ikk, is a kinase critical for activation of nf-κb by mediating phosphorylation and degradation of iκbα. the induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream nf-κb-mediated transcription[1].
Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.
in vitro
in cultured mouse balb/c 3t3 cells, mouse splenocytes and hela cells, wedelolactone (0~100 μm) inhibited lps-induced caspase-11 expression by inhibiting nf-κb-mediated transcription through the direct inhibition of ikk. wedelolactone played an potential role in anti-inflammatory therapy to inhibit il-1β levels in diseases such as rheumatoid arthritis, asthma and septic shock[1].
in vivo
on swiss albino male mouse skin, ikk inhibition by wedelolactone (10 μm) prevented the induction of nf-κb, perturbed the generation of reactive oxygen species and reactive nitrogen intermediates, blunted the signal transduction that lead to the activation of the early immediate genes, and thereby protected mouse skin from the uvb induced neoplastic transformation, angiotropism and metastatic progression [2].
References
[1] kobori m, yang z, gong d, et al. wedelolactone suppresses lps-induced caspase-11 expression by directly inhibiting the ikk complex.[j]. cell death & differentiation, 2004, 11(1):123-30.
[2] ali f, khan b a, sultana s. wedelolactone mitigates uvb induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of nfκb pathway[j]. european journal of pharmacology, 2016, 786:253-264.
WEDELOLACTONE Preparation Products And Raw materials
Raw materials
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View Lastest Price from WEDELOLACTONE manufacturers
- Product
- Wedelolactone 524-12-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- SkiMMin 524-12-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- Wedelolactone 524-12-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-22