ChemicalBook > CAS DataBase List > WEDELOLACTONE

WEDELOLACTONE

Product Name: WEDELOLACTONE
CAS No.: 524-12-9
Chemical Name: WEDELOLACTONE
Synonyms: Wedelolactone;Wedelia lactone;Wedelolactone-RM;Wedelolactone CRS;Wedelolactone, ≥98%(HPLC);Wedelolactone, 10 mM in DMSO;IKK Inhibitor II, Wedelolactone;5,11,12-Trihydroxy-7-MethoxycouMestan;Wedelolactone, IkappaB kinase inhibitor;Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.
CBNumber: CB1505300
Molecular Formula: C16H10O7
Formula Weight: 314.25
MOL File: 524-12-9.mol

Less

WEDELOLACTONE Property

Melting point:: 327～330℃
Boiling point:: 498.4±45.0 °C(Predicted)
Density: 1.655±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 14 mg/mL, soluble
form: solid
pka: 6.90±0.20(Predicted)
color: brown-beige
InChI: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChIKey: XQDCKJKKMFWXGB-UHFFFAOYSA-N
SMILES: C1(=O)OC2=CC(OC)=CC(O)=C2C2OC3=CC(O)=C(O)C=C3C1=2

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3
HS Code: 29322090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001599
Product name: Wedelolactone
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: W4016
Product name: Wedelolactone
Purity: ≥98% (HPLC), powder
Packaging: 1mg
Price: $171
Updated: 2025/07/31

TCI Chemical

Product number: W0015
Product name: Wedelolactone
Packaging: 1MG
Price: $106
Updated: 2025/07/31

TCI Chemical

Product number: W0015
Product name: Wedelolactone
Packaging: 10MG
Price: $477
Updated: 2025/07/31

Cayman Chemical

Product number: 11796
Product name: Wedelolactone
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Less

WEDELOLACTONE Chemical Properties,Usage,Production

Chemical Properties

Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether, dichloromethane, chloroform. Sourced from the above-ground parts of Eclipta prostrasta L., Asteraceae.

Uses

Wedelolactone is inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.

Definition

ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.

Biological Activity

wedelolactone is an inhibitor of ikk.ikb kinase (ikk) complex contains the catalytic subunits ikkα and ikkβ, and the regulatory subunit ikkγ/nemo. ikk, is a kinase critical for activation of nf-κb by mediating phosphorylation and degradation of iκbα. the induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream nf-κb-mediated transcription[1].

Biochem/physiol Actions

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

in vitro

in cultured mouse balb/c 3t3 cells, mouse splenocytes and hela cells, wedelolactone (0~100 μm) inhibited lps-induced caspase-11 expression by inhibiting nf-κb-mediated transcription through the direct inhibition of ikk. wedelolactone played an potential role in anti-inflammatory therapy to inhibit il-1β levels in diseases such as rheumatoid arthritis, asthma and septic shock[1].

in vivo

on swiss albino male mouse skin, ikk inhibition by wedelolactone (10 μm) prevented the induction of nf-κb, perturbed the generation of reactive oxygen species and reactive nitrogen intermediates, blunted the signal transduction that lead to the activation of the early immediate genes, and thereby protected mouse skin from the uvb induced neoplastic transformation, angiotropism and metastatic progression [2].

References

[1] kobori m, yang z, gong d, et al. wedelolactone suppresses lps-induced caspase-11 expression by directly inhibiting the ikk complex.[j]. cell death & differentiation, 2004, 11(1):123-30.
[2] ali f, khan b a, sultana s. wedelolactone mitigates uvb induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of nfκb pathway[j]. european journal of pharmacology, 2016, 786:253-264.

WEDELOLACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

WEDELOLACTONE Suppliers

China 252 China Hong Kong 1 Germany 2 India 5 Japan 1 Switzerland 1 United Kingdom 1 United States 17 Global 280

Huzhou ZhanShu Biotechnology Co.,Ltd

Tel: 0572-8889530 18167260939
Email: zsubio@163.com
Country: China
ProdList: 392
Advantage: 58

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3842
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Shanghai Zhanshu Chemical Technology Co., Ltd

Tel: +86-21-58589556
Fax: +86-21-58589557
Country: China
ProdList: 413
Advantage: 55

Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
Country: China
ProdList: 813
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9986
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Watec Laboratories, Inc.

Tel: 18602586511
Fax: 0519-85267382
Email: info@wateclaboratories.com
Country: China
ProdList: 170
Advantage: 60

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4808
Advantage: 58

WG reagent

Tel: 13391486464
Fax: QQ:14748090
Email: samwjf@163.com
Country: China
ProdList: 3086
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4992
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13856024262
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2992
Advantage: 55

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5093
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5095
Advantage: 55

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9996
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Less

View Lastest Price from WEDELOLACTONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Wedelolactone 524-12-9
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Shaanxi Dideu Medichem Co. Ltd

Product: SkiMMin 524-12-9
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Shanghai Standard Technology Co., Ltd.

Product: Wedelolactone 524-12-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-22

524-12-9, WEDELOLACTONERelated Search:

ecliptasaponin D ECHINOCYSTIC ACID-3-GLUCOSIDE Hypericin 3-HYDROXY-9-METHOXYCOUMESTAN 2,4,8,9-Tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one WILFORINE Kidney Bean Extract ISOBERGAPTOL 4-METHYLESCULETIN 5-Hydroxyxanthotoxin pimpinellin MEDICAGOL 5,7-Dihydroxy-4-methylcoumarin 5,8-DIHYDROXYPSORALEN 4-Hydroxycoumarin 6-ISOPENTENYLOXYISOBERGAPTEN Worenine WILFORDINE

Wedelolactone, ≥98%(HPLC)

IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

Wedelolactone

6H-Benzofuro(3,2-C)(1)benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-

5,11,12-Trihydroxy-7-MethoxycouMestan

1,8,9-trihydroxy-3-Methoxy-6H-benzofuro[3,2-c]chroMen-6-one

IKK Inhibitor II, Wedelolactone

Wedelia lactone

Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.

Wedelolactone CRS

1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one[Wedelolactone

Wedelolactone-RM

Wedelolactone, IkappaB kinase inhibitor

Wedelolactone, 10 mM in DMSO

524-12-9

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract