Apremilast-d8
- Product Name
- Apremilast-d8
- CAS No.
- 1258597-45-3
- Chemical Name
- Apremilast-d8
- Synonyms
- APREMILAST-D8;Apremilast Impurity 68;rac-3’-O-Desethyl-3’-O-methyl Apremilast-d3
- CBNumber
- CB15585031
- Molecular Formula
- C22H24N2O7S
- Formula Weight
- 460.5
- MOL File
- 1258597-45-3.mol
Apremilast-d8 Chemical Properties,Usage,Production
Uses
Apremilast-d8 (CC-10004-d8) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249. DOI:10.1186/s13075-015-0771-6
[3] Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40. DOI:10.1093/chromsci/bmw072
Apremilast-d8 Preparation Products And Raw materials
Raw materials
Preparation Products
Apremilast-d8 Suppliers
- Tel
- 15022261580 15022261580;
- tjshj1212@163.com
- Country
- China
- ProdList
- 2697
- Advantage
- 58
- Tel
- 17301488900
- Fax
- 025-85560043
- judy.xia@synzest.com
- Country
- China
- ProdList
- 12582
- Advantage
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