Apremilast-d8

Product Name: Apremilast-d8
CAS No.: 1258597-45-3
Chemical Name: Apremilast-d8
Synonyms: APREMILAST-D8;Apremilast Impurity 68;rac-3’-O-Desethyl-3’-O-methyl Apremilast-d3
CBNumber: CB15585031
Molecular Formula: C22H24N2O7S
Formula Weight: 460.5
MOL File: 1258597-45-3.mol

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Hazard and Precautionary Statements (GHS)

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Apremilast-d8 Chemical Properties,Usage,Production

Uses

Apremilast-d8 (CC-10004-d8) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249. DOI:10.1186/s13075-015-0771-6
[3] Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40. DOI:10.1093/chromsci/bmw072

Apremilast-d8 Preparation Products And Raw materials

Raw materials

Preparation Products

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Apremilast-d8 Suppliers

China 2 India 4 Global 6

SynZeal Research Pvt Ltd

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Pharma Affiliates

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Pharmaffiliates Analytics and Synthetics P. Ltd

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1258597-45-3, Apremilast-d8Related Search:

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APREMILAST-D8

Apremilast Impurity 68

rac-3’-O-Desethyl-3’-O-methyl Apremilast-d3

1258597-45-3