4-Nitrophthalic acid
- Product Name
- 4-Nitrophthalic acid
- CAS No.
- 610-27-5
- Chemical Name
- 4-Nitrophthalic acid
- Synonyms
- 4-NPA;1,2-Benzenedicarboxylic acid, 4-nitro-;NSC 5395;AKOS B028755;4-NitrophthaL;4-Nitrophthalic;4-nitro-phthalate;4-Nitrophthalicaci;RARECHEM AL BO 1138;-Nitrophthalic Acid
- CBNumber
- CB3467453
- Molecular Formula
- C8H5NO6
- Formula Weight
- 211.13
- MOL File
- 610-27-5.mol
4-Nitrophthalic acid Property
- Melting point:
- 159-161 °C (lit.)
- Boiling point:
- 350.79°C (rough estimate)
- Density
- 1.6342 (rough estimate)
- refractive index
- 1.5282 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 880g/l
- form
- Crystalline Powder
- pka
- pK1:2.11 (25°C)
- color
- Yellow to beige
- PH
- 1 (10g/l, H2O, 20℃)
- Odor
- Odorless
- PH Range
- 1
- Water Solubility
- 880 g/l at 20 °C
- BRN
- 1882262
- InChIKey
- SLBQXWXKPNIVSQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 610-27-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1,2-Benzenedicarboxylic acid, 4-nitro- (610-27-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29173980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274755
- Product name
- 4-Nitrophthalic acid
- Purity
- 92%
- Packaging
- 25g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- 274755
- Product name
- 4-Nitrophthalic acid
- Purity
- 92%
- Packaging
- 5g
- Price
- $35.8
- Updated
- 2023/06/20
- Product number
- N0244
- Product name
- 4-Nitrophthalic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- N0244
- Product name
- 4-Nitrophthalic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500g
- Price
- $630
- Updated
- 2025/07/31
- Product number
- 73775
- Product name
- 4-Nitrophthalic acid
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $96.8
- Updated
- 2022/05/15
4-Nitrophthalic acid Chemical Properties,Usage,Production
Chemical Properties
Light-Beige Solid
Uses
4-Nitrophthalic Acid is an impurity of Apremilast.
General Description
The tissue-specific activity of 4-nitrophthalic acid was studied.
Synthesis
31643-49-9
610-27-5
The general procedure for the synthesis of 4-nitrophthalic acid from 4-nitrophthalonitrile was as follows: 4-nitrophthalonitrile (2 mmol) was dissolved in 5 ml of [bmim]HSO4 ionic liquid and the reaction mixture was heated at 60-65°C for 1-3 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was poured into water containing crushed ice to induce precipitation of the product. Subsequently, the precipitate is collected by filtration and dried. The product yield of this method was generally higher than 90% and the purity of the product met the requirements without further purification. The filtrate was concentrated under vacuum, washed twice with diethyl ether and concentrated again under high vacuum. After drying, about 95% of the ionic liquid was recovered, and its authenticity was verified by comparison with the original ionic liquid. The recovered ionic liquid showed comparable efficiency to the original ionic liquid in the reaction of converting nitrile to acid and could be reused 5-6 times without significant reduction in activity.
Purification Methods
Crystallise 4-nitrophthalic acid from Et2O, EtOAc or *C6H6 (m 166o). The amide has m 200o (from EtOH). [Beilstein 9 H 828, 9 IV 4234.]
References
[1] Tetrahedron Letters, 2014, vol. 55, # 28, p. 3802 - 3804
4-Nitrophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Nitrophthalic acid manufacturers
- Product
- 4-Nitrophthalic acid 610-27-5
- Price
- US $44.65/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 3tons/month
- Release date
- 2023-12-08
- Product
- 4-Nitrophthalic acid 610-27-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- Pomalidomide Impurity 44 610-27-5
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-27