TRAIL (C92B9) Rabbit mAb

Hazard and Precautionary Statements (GHS)

TRAIL (C92B9) Rabbit mAb Chemical Properties,Usage,Production

Source

Rabbit

Reactivity

Human

Background

Tumor necrosis factor-related apoptosis-inducing ligand, also referred to as Apo2 ligand, first identified based on its sequence homology to TNF and Fas/Apo ligand is a member of the TNF family of cytokines and either exists as a type II membrane or soluble protein. TRAIL induces apoptosis in a variety of transformed cell lines and plays a role in anti-tumor and anti-viral immune surveillance. TRAIL signals via binding with death receptors DR4 and DR5 which can trigger apoptosis as well as NF-κB activation. Death domains on these receptors leads to the recruitment of a death-induced signaling complex leading to caspase-8 and subsequent caspase-3 activation. In addition, TRAIL binds with decoy receptors DcR1 and DcR2 which lack the functional cytoplasmic death domain antagonizing TRAIL-induced apoptosis. Osteoprotegerin has also been identified as receptor capable of inhibiting TRAIL-induced apoptosis. The selectivity of soluble TRAIL at triggering apoptosis in transformed cells as compared to normal cells has led to its investigation as a potential cancer therapeutic.

References

[1] Wiley, S.R. et al. (1995) Immunity 3, 673-82.
[2] Pitti, R.M. et al. (1996) J Biol Chem 271, 12687-90.
[3] Almasan, A. and Ashkenazi, A. Cytokine Growth Factor Rev 14, 337-48.
[4] Pan, G. et al. (1997) Science 276, 111-3.
[5] Walczak, H. et al. (1997) EMBO J 16, 5386-97.
[6] MacFarlane, M. et al. (1997) J Biol Chem 272, 25417-20.
[7] Chaudhary, P.M. et al. (1997) Immunity 7, 821-30.
[8] Schneider, P. et al. (1997) FEBS Lett 416, 329-34.
[9] Shetty, S. et al. (2002) Apoptosis 7, 413-20.
[10] Sheridan, J.P. et al. (1997) Science 277, 818-21.