CL2 Linker

Product Name: CL2 Linker
CAS No.: 2270986-66-6
Chemical Name: CL2 Linker
Synonyms: CL2 Linker;tert-butyl N-[(5S)-5-[(2S)-2-[1-(4-{[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]methyl}-1H-1,2,3-triazol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amido]-3-phenylpropanamido]-5-{[4-({[(2-{[(3-hydroxy-2-oxopropoxy)carbonyl](methyl)amino}ethyl)(methyl)carbamoyl]oxy}methyl)phenyl]carbamoyl}pentyl]carbamate
CBNumber: CB15821128
Molecular Formula: C68H103N11O22
Formula Weight: 1426.61
MOL File: 2270986-66-6.mol

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CL2 Linker Property

Density: 1.26±0.1 g/cm3(Predicted)
pka: 12.65±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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CL2 Linker Chemical Properties,Usage,Production

Uses

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

IC 50

Acid Cleavable Linker; Cleavable Linker

References

[1] Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26. DOI:10.1021/jm800719t
[2] Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. DOI:10.1158/1078-0432.CCR-10-2939

CL2 Linker Preparation Products And Raw materials

Raw materials

Preparation Products

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CL2 Linker Suppliers

China 10 United States 2 Global 12

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

MedChemExpress

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Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

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CL2 Linker

tert-butyl N-[(5S)-5-[(2S)-2-[1-(4-{[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]methyl}-1H-1,2,3-triazol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amido]-3-phenylpropanamido]-5-{[4-({[(2-{[(3-hydroxy-2-oxopropoxy)carbonyl](methyl)amino}ethyl)(methyl)carbamoyl]oxy}methyl)phenyl]carbamoyl}pentyl]carbamate

2270986-66-6

C68H103N11O22