EGS Crosslinker
- Product Name
- EGS Crosslinker
- CAS No.
- 70539-42-3
- Chemical Name
- EGS Crosslinker
- Synonyms
- EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
- CBNumber
- CB5722624
- Molecular Formula
- C18H20N2O12
- Formula Weight
- 456.36
- MOL File
- 70539-42-3.mol
EGS Crosslinker Property
- Boiling point:
- 603.4±65.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- acetic acid: water (1:1): ≤50mg/mL
- form
- powder
- BRN
- 9167119
- InChI
- InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
- InChIKey
- QLHLYJHNOCILIT-UHFFFAOYSA-N
- SMILES
- O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O
Safety
- WGK Germany
- 3
- F
- 10
- HS Code
- 29280000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E3257
- Product name
- Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
- Purity
- powder
- Packaging
- 250mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- E3257
- Product name
- Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
- Purity
- powder
- Packaging
- 1g
- Price
- $498
- Updated
- 2024/03/01
- Product number
- CHM0014396
- Product name
- ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE)
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $708.48
- Updated
- 2021/12/16
- Product number
- JK359030
- Product name
- Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
- Purity
- 95%
- Packaging
- 50mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- JK359030
- Product name
- Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
- Purity
- 95%
- Packaging
- 250mg
- Price
- $126
- Updated
- 2021/12/16
EGS Crosslinker Chemical Properties,Usage,Production
Description
EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.
Uses
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.
Biochem/physiol Actions
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.
Properties and Applications
EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.
EGS Crosslinker Preparation Products And Raw materials
Raw materials
Preparation Products
EGS Crosslinker Suppliers
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View Lastest Price from EGS Crosslinker manufacturers
- Product
- Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester) 70539-42-3
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-06
- Product
- EGS 70539-42-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-23
- Product
- EGS 70539-42-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10