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EGS Crosslinker

Product Name
EGS Crosslinker
CAS No.
70539-42-3
Chemical Name
EGS Crosslinker
Synonyms
EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
CBNumber
CB5722624
Molecular Formula
C18H20N2O12
Formula Weight
456.36
MOL File
70539-42-3.mol
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EGS Crosslinker Property

Boiling point:
603.4±65.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
acetic acid: water (1:1): ≤50mg/mL
form 
powder
color 
White to off-white
BRN 
9167119
InChI
InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
InChIKey
QLHLYJHNOCILIT-UHFFFAOYSA-N
SMILES
O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O
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Safety

WGK Germany 
3
10
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
250mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
1g
Price
$498
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0014396
Product name
ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE)
Purity
95.00%
Packaging
1G
Price
$708.48
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
50mg
Price
$39
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
250mg
Price
$126
Updated
2021/12/16
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EGS Crosslinker Chemical Properties,Usage,Production

Description

EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.

Uses

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.

Biochem/physiol Actions

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.

Properties and Applications

EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.

EGS Crosslinker Preparation Products And Raw materials

Raw materials

Preparation Products

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EGS Crosslinker Suppliers

Suzhouhongxiong
Tel
18051745768 18051745768
Email
Suzhouhongxiong@163.com
Country
China
ProdList
70
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
979
Advantage
60
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
CovaChem, LLC.
Tel
+1815.714.8421 (direct)
Fax
+1815.315.1272
Email
tonynooner@covachem.com
Country
United States
ProdList
89
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
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View Lastest Price from EGS Crosslinker manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester) 70539-42-3
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-06
Henan Aochuang Chemical Co.,Ltd.
Product
EGS 70539-42-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
EGS 70539-42-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

70539-42-3, EGS CrosslinkerRelated Search:


  • ethylene glycol-bis(succinic acid n-hydroxysuccinimide
  • EGNHS
  • ethyleneglycolylbis(succinimidylsuccinate
  • ETHYLENE GLYCOL BIS-(SUCCINIC ACID*N-HYD ROXYSUCCINI
  • Ethlene glycol bis(succinimidyl succinate)
  • Ethyleneglycol-O,O''-bis-(succinic acid N-hydroxysuccinimide ester)
  • Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester
  • Ethylene Glycol Bis(succinic Acid N-Hydrosuccinimide Ester)
  • HI-EFF-2B
  • LAC-4R-886
  • Butanoic acid, 4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-, 1,2-ethanediyl ester
  • Ethylene glycol bis(succininic acid) N-hydroxysucciniMide ester
  • Ethylene glycol bis(succiniMidylsuccinate)(EGS)
  • EGS Crosslinker (ethylene glycol bis(succinimidyl succinate))
  • DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE
  • EGS
  • ETHYLENE GLYCOL-BIS(SUCCINIC ACID N-HYDROXYSUCCINIMIDE ESTER)
  • ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE)
  • ETHYLENE GLYCOL DISUCCINATE DI(N-SUCCINIMIDYL) ESTER
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • EGS Crosslinker
  • 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
  • Butanedioic acid, 1,1'-(1,2-ethanediyl) 4,4'-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxob...
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoate}
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • 70539-42-3
  • C18H20N2O12
  • Active Esters/Additives
  • Coupling
  • Synthetic Reagents
  • homoXlink
  • Homobifunctional Crosslinker