ChemicalBook > CAS DataBase List > EGS Crosslinker

EGS Crosslinker

Product Name
EGS Crosslinker
CAS No.
70539-42-3
Chemical Name
EGS Crosslinker
Synonyms
EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
CBNumber
CB5722624
Molecular Formula
C18H20N2O12
Formula Weight
456.36
MOL File
70539-42-3.mol
More
Less

EGS Crosslinker Property

Boiling point:
603.4±65.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
acetic acid: water (1:1): ≤50mg/mL
form 
powder
BRN 
9167119
InChI
InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
InChIKey
QLHLYJHNOCILIT-UHFFFAOYSA-N
SMILES
O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O
More
Less

Safety

WGK Germany 
3
F 
10
HS Code 
29280000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
250mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
1g
Price
$498
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0014396
Product name
ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE)
Purity
95.00%
Packaging
1G
Price
$708.48
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
50mg
Price
$39
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
250mg
Price
$126
Updated
2021/12/16
More
Less

EGS Crosslinker Chemical Properties,Usage,Production

Description

EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.

Uses

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.

Biochem/physiol Actions

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.

Properties and Applications

EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.

EGS Crosslinker Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

EGS Crosslinker Suppliers

China 75 Europe 1 France 1 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 104
Suzhouhongxiong
Tel
18051745768 18051745768
Email
Suzhouhongxiong@163.com
Country
China
ProdList
100
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7639
Advantage
55
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
994
Advantage
60
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10269
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15885
Advantage
55
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5934
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Watson Biotechnology Co.,Ltd
Tel
027-027-59207879 18140587686
Fax
QQ：1972026995
Email
kf@3600chem.com
Country
China
ProdList
4697
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6357
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28821
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19806
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15085
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24971
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3245
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Hunan chemfish Scientific co.,ltd
Tel
+8618229978283 18974947952
Email
sales@chemfish.com
Country
China
ProdList
4908
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55954
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10097
Advantage
58
Changzhou Ansciep Chemical Co., Ltd.
Tel
0519-86305871 2719466718
Email
tina@ansciepchem.com
Country
China
ProdList
1918
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8618339805032
Email
alfa4@alfachem.cn
Country
China
ProdList
13040
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
+86-027-59207850
Fax
86-27-59524646
Email
info@fortunachem.com
Country
China
ProdList
5999
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19915
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9330
Advantage
58
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
Tel
029-86217788 13892832556
Email
2440688701@qq.com
Country
China
ProdList
1992
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49391
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49323
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
18642120371
Email
2837458851@qq.com
Country
China
ProdList
9874
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44486
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4495
Advantage
58
Zhengzhou Akem Chemical Co., Ltd
Tel
13303867194
Email
3001317055@qq.com
Country
China
ProdList
9627
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9242
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10624
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815987 13927875076
Fax
0751-2828607
Email
3007432263@qq.com
Country
China
ProdList
9978
Advantage
58
Hu' nan Yunbang Pharmaceutical Co., Ltd.
Tel
0731-85561020 15386497078
Email
yunbang@yunbangapi.com
Country
China
ProdList
4247
Advantage
58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
et@chemextension.com
Country
China
ProdList
5061
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323 15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Email
wuhao@highfine.com
Country
China
ProdList
1352
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27996
Advantage
58
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd
Tel
18072846723
Email
caigou1@witofly.com
Country
China
ProdList
18925
Advantage
58
Henan Dowon Chemical Technology Co., Ltd.
Tel
16603857855
Email
779113375@qq.com
Country
China
ProdList
6731
Advantage
58
Shaanxi Didu New Material Co., Ltd
Tel
029-63373950 15353716720
Email
1052@dideu.com
Country
China
ProdList
10011
Advantage
58
More
Less

View Lastest Price from EGS Crosslinker manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester) 70539-42-3
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-06
Henan Aochuang Chemical Co.,Ltd.
Product
EGS 70539-42-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
EGS 70539-42-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

70539-42-3, EGS CrosslinkerRelated Search:

2-HYDROXYETHYL ACETATE Ethylenebis(oxyethylenenitrilo)tetraacetic acid 2-(Vinyloxy)ethanol Ethylene Glycol Bis(propionitrile) Ether DST 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N- DISULFOSUCCINIMIDYL TARTRATE DISUCCINIMIDYL SUBERATE Ethylene glycol ETHYLENE GLYCOLBIS(SULPHOSUCCINIMIDYLSUCCINATE) EGS Crosslinker SULFO-EGS

  • ethylene glycol-bis(succinic acid n-hydroxysuccinimide
  • EGNHS
  • ethyleneglycolylbis(succinimidylsuccinate
  • ETHYLENE GLYCOL BIS-(SUCCINIC ACID*N-HYD ROXYSUCCINI
  • Ethlene glycol bis(succinimidyl succinate)
  • Ethyleneglycol-O,O''-bis-(succinic acid N-hydroxysuccinimide ester)
  • Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester
  • Ethylene Glycol Bis(succinic Acid N-Hydrosuccinimide Ester)
  • HI-EFF-2B
  • LAC-4R-886
  • Butanoic acid, 4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-, 1,2-ethanediyl ester
  • Ethylene glycol bis(succininic acid) N-hydroxysucciniMide ester
  • Ethylene glycol bis(succiniMidylsuccinate)(EGS)
  • EGS Crosslinker (ethylene glycol bis(succinimidyl succinate))
  • DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE
  • EGS
  • ETHYLENE GLYCOL-BIS(SUCCINIC ACID N-HYDROXYSUCCINIMIDE ESTER)
  • ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE)
  • ETHYLENE GLYCOL DISUCCINATE DI(N-SUCCINIMIDYL) ESTER
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • EGS Crosslinker
  • 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
  • Butanedioic acid, 1,1'-(1,2-ethanediyl) 4,4'-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxob...
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoate}
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • 70539-42-3
  • C18H20N2O12
  • Active Esters/Additives
  • Coupling
  • Synthetic Reagents
  • homoXlink
  • Homobifunctional Crosslinker