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EGS Crosslinker

Product Name
EGS Crosslinker
CAS No.
70539-42-3
Chemical Name
EGS Crosslinker
Synonyms
EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
CBNumber
CB5722624
Molecular Formula
C18H20N2O12
Formula Weight
456.36
MOL File
70539-42-3.mol
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EGS Crosslinker Property

Boiling point:
603.4±65.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
acetic acid: water (1:1): ≤50mg/mL
form 
powder
color 
White to off-white
BRN 
9167119
InChI
InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
InChIKey
QLHLYJHNOCILIT-UHFFFAOYSA-N
SMILES
O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O
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Safety

WGK Germany 
3
F 
10
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
250mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
E3257
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
powder
Packaging
1g
Price
$498
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0014396
Product name
ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE)
Purity
95.00%
Packaging
1G
Price
$708.48
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
50mg
Price
$39
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK359030
Product name
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity
95%
Packaging
250mg
Price
$126
Updated
2021/12/16
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EGS Crosslinker Chemical Properties,Usage,Production

Description

EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.

Uses

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.

Biochem/physiol Actions

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.

Properties and Applications

EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.

EGS Crosslinker Preparation Products And Raw materials

Raw materials

Preparation Products

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EGS Crosslinker Suppliers

China 84 Europe 1 France 1 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 113
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from EGS Crosslinker manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester) 70539-42-3
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-06
Henan Aochuang Chemical Co.,Ltd.
Product
EGS 70539-42-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
EGS 70539-42-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

70539-42-3, EGS CrosslinkerRelated Search:

2-HYDROXYETHYL ACETATE Ethylenebis(oxyethylenenitrilo)tetraacetic acid 2-(Vinyloxy)ethanol Ethylene Glycol Bis(propionitrile) Ether DST 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N- DISULFOSUCCINIMIDYL TARTRATE DISUCCINIMIDYL SUBERATE Ethylene glycol ETHYLENE GLYCOLBIS(SULPHOSUCCINIMIDYLSUCCINATE) EGS Crosslinker SULFO-EGS

  • ethylene glycol-bis(succinic acid n-hydroxysuccinimide
  • EGNHS
  • ethyleneglycolylbis(succinimidylsuccinate
  • ETHYLENE GLYCOL BIS-(SUCCINIC ACID*N-HYD ROXYSUCCINI
  • Ethlene glycol bis(succinimidyl succinate)
  • Ethyleneglycol-O,O''-bis-(succinic acid N-hydroxysuccinimide ester)
  • Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester
  • Ethylene Glycol Bis(succinic Acid N-Hydrosuccinimide Ester)
  • HI-EFF-2B
  • LAC-4R-886
  • Butanoic acid, 4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-, 1,2-ethanediyl ester
  • Ethylene glycol bis(succininic acid) N-hydroxysucciniMide ester
  • Ethylene glycol bis(succiniMidylsuccinate)(EGS)
  • EGS Crosslinker (ethylene glycol bis(succinimidyl succinate))
  • DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE
  • EGS
  • ETHYLENE GLYCOL-BIS(SUCCINIC ACID N-HYDROXYSUCCINIMIDE ESTER)
  • ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE)
  • ETHYLENE GLYCOL DISUCCINATE DI(N-SUCCINIMIDYL) ESTER
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • EGS Crosslinker
  • 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
  • Butanedioic acid, 1,1'-(1,2-ethanediyl) 4,4'-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxob...
  • ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoate}
  • Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate
  • 70539-42-3
  • C18H20N2O12
  • Active Esters/Additives
  • Coupling
  • Synthetic Reagents
  • homoXlink
  • Homobifunctional Crosslinker