DOFETILIDE-D4

Product Name: DOFETILIDE-D4
CAS No.: 1189700-56-8
Chemical Name: DOFETILIDE-D4
Synonyms: Tikosyn-d;Tikosyn-d4;UK 68789 D4;UK-68798-d4;DOFETILIDE-D4;N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4;N-[4-(2-{[2-(4-methanesulfonamidophenoxy)(1,1,2,2-2H?)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide;Dofetilide D4Q: What is Dofetilide D4 Q: What is the CAS Number of Dofetilide D4 Q: What is the storage condition of Dofetilide D4 Q: What are the applications of Dofetilide D4
CBNumber: CB1648928
Molecular Formula: C19H27N3O5S2
Formula Weight: 441.56478
MOL File: 1189700-56-8.mol

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DOFETILIDE-D4 Property

Melting point:: 130-1350C
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White
CAS DataBase Reference: 1189700-56-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26451
Product name: Dofetilide-d4
Packaging: 500μg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 26451
Product name: Dofetilide-d4
Packaging: 1mg
Price: $290
Updated: 2024/03/01

Usbiological

Product number: D8079-25C
Product name: Dofetilide-d4
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: D525702
Product name: Dofetilide-d4
Packaging: 10mg
Price: $1455
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D3782
Product name: Dofetilide-d4
Purity: 98%
Packaging: 1mg
Price: $950
Updated: 2021/12/16

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DOFETILIDE-D4 Chemical Properties,Usage,Production

Description

Dofetilide-d₄ is intended for use as an internal standard for the quantification of dofetilide by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K⁺ current (IC₅₀ = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.

Chemical Properties

White Crystalline Solid

Uses

Potassium channel blocker.

Uses

Dofetilide-d4 is intended for use as an internal standard for the quantification of Dofitilide by GC- or LC-mass spectrometry.

References

[1] N K JURKIEWICZ M C S. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.[J]. Circulation research, 1993, 72 1: 75-83. DOI: 10.1161/01.res.72.1.75
[2] L NALOS. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes[J]. British Journal of Pharmacology, 2011, 165 2: 467-478. DOI: 10.1111/j.1476-5381.2011.01558.x
[3] ALBERT DUNNINK. Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.[J]. Europace, 2012, 14 3: 431-436. DOI: 10.1093/europace/eur311

DOFETILIDE-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

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DOFETILIDE-D4 Suppliers

Canada 2 China 31 India 4 United States 5 Global 42

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1189700-56-8, DOFETILIDE-D4Related Search:

Bithionol Dofetilide

DOFETILIDE-D4

UK-68798-d4

N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4

Tikosyn-d

Tikosyn-d4

UK 68789 D4

Dofetilide D4Q: What is Dofetilide D4 Q: What is the CAS Number of Dofetilide D4 Q: What is the storage condition of Dofetilide D4 Q: What are the applications of Dofetilide D4

N-[4-(2-{[2-(4-methanesulfonamidophenoxy)(1,1,2,2-2H?)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide

1189700-56-8

C19H23D4N3O5S2

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

Sulfur & Selenium Compounds

Isotope Labelled Compounds