TRIETHYL 4-PHOSPHONOCROTONATE

Product Name: TRIETHYL 4-PHOSPHONOCROTONATE
CAS No.: 10236-14-3
Chemical Name: TRIETHYL 4-PHOSPHONOCROTONATE
Synonyms: Ethyl 4-(diethoxyphosphoryl);TRIETHYL 4-PHOSPHONOCROTONATE;TRIETHYL 4-PHOSPHONO-2-BUTENOATE;triethyl trans-4-phosphono-2-butenoate;4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER;Ethyl 4-(diethoxyphosphinyl)-2-butenoate;TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE;triethyl 4-phosphonocrotonate, cis + trans;(E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate;Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate
CBNumber: CB1664375
Molecular Formula: C10H19O5P
Formula Weight: 250.23
MOL File: 10236-14-3.mol

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TRIETHYL 4-PHOSPHONOCROTONATE Property

Boiling point:: 135 °C0.4 mm Hg(lit.)
Density: 1.128 g/mL at 25 °C(lit.)
refractive index: n20/D 1.455(lit.)
Flash point:: >230 °F
storage temp.: Storage temp. 2-8°C
form: Liquid
color: Clear light yellow
InChI: 1S/C10H19O5P/c1-4-13-10(11)8-7-9-16(12,14-5-2)15-6-3/h7-8H,4-6,9H2,1-3H3/b8-7+
InChIKey: LXLODBXSCRTXFG-BQYQJAHWSA-N
SMILES: CCOC(=O)\C=C\CP(=O)(OCC)OCC
CAS DataBase Reference: 10236-14-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 116092
Product name: Triethyl 4-phosphonocrotonate, mixture of isomers
Purity: technical grade, 90%
Packaging: 10g
Price: $56
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FD58008
Product name: 4-(Diethoxyphosphinyl)-2-butenoic acid ethyl ester
Packaging: 2g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 002602
Product name: Triethyl 4-phosphonocrotonate
Purity: 90+%
Packaging: 5g
Price: $56
Updated: 2021/12/16

Apolloscientific

Product number: OR42028
Product name: Ethyl 4-(diethoxyphosphoryl)crotonate
Purity: 94%
Packaging: 1g
Price: $88
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK105784
Product name: Triethyl4-phosphonocrotonate,92%,predominantlytrans
Packaging: 10g
Price: $100
Updated: 2021/12/16

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TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties,Usage,Production

Chemical Properties

CLEAR LIGHT YELLOW LIQUID

Uses

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Uses

Reactant for:

Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
Orally bioavailable GPR40 agonist synthesis
Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
Preaparation of mGlu4R agonists
Dearomatizing cyclization of nicotinyl-substituted esters and ketones

reaction suitability

reaction type: C-C Bond Formation

TRIETHYL 4-PHOSPHONOCROTONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIETHYL 4-PHOSPHONOCROTONATE Suppliers

Belgium 1 China 41 France 1 Germany 2 India 5 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 68

J & K SCIENTIFIC LTD.

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View Lastest Price from TRIETHYL 4-PHOSPHONOCROTONATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: TRIETHYL 4-PHOSPHONOCROTONATE 10236-14-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-05-16

10236-14-3, TRIETHYL 4-PHOSPHONOCROTONATERelated Search:

TRIETHYL 4-PHOSPHONOBUTYRATE TRIETHYL 3-PHOSPHONOPROPIONATE Dimethyl methylphosphonate DIMETHYL ETHYLPHOSPHONATE DIETHYL ALLYLPHOSPHONATE Methyldiethoxyphosphine DIMETHYL ALLYLPHOSPHONATE ETHYL METHYLPHOSPHONIC ACID METHYLPHOSPHONIC ACID ETHYLPHOSPHONIC ACID TRIETHYL 4-PHOSPHONOCROTONATE DIMETHYL ETHYLPHOSPHONITE DIETHYL ETHYLPHOSPHONATE Diethyl methylphosphonate TRIMETHYL 4-PHOSPHONOCROTONATE TRIETHYL 3-METHYL-4-PHOSPHONOCROTONATE ETHYL HYDROGEN ETHYLPHOSPHONATE ALLYLPHOSPHONIC ACID

4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER

TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE

TRIETHYL 4-PHOSPHONO-2-BUTENOATE

TRIETHYL 4-PHOSPHONOCROTONATE

TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS

Triethyl 4-phosphonocrotonate, predominantly trans, 92%

triethyl 4-phosphonocrotonate, cis + trans

triethyl 4-phosphonocrotonate, mixture of isomers

triethyl trans-4-phosphono-2-butenoate

Triethyl 4-phosphonocrotonate, cis + trans, tech. 90%

Triethyl 4-phosphonocrotonate, 92%, predominantly trans

(E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate

Ethyl 4-(diethoxyphosphoryl)but-2-enoate, Ethyl 4-(diethylphosphono)crotonate

Triethyl 4-phosphonocrotonate, predoMinantly trans, 92% 50GR

Triethyl 4-phosphonocrotonate, mixture of isomers technical grade, 90%

Triethyl 4-phosphonocrotonate, cis and trans, technical, 90%

Ethyl 4-(diethoxyphosphoryl)

2-Butenoic acid, 4-(diethoxyphosphinyl)-, ethyl ester

Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate

Ethyl 4-(diethoxyphosphinyl)-2-butenoate

10236-14-3

C2H5O2POCH2CHCHCO2C2H5

C10H19O5P

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

Synthetic Reagents

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination