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TRIETHYL 4-PHOSPHONOCROTONATE

Product Name
TRIETHYL 4-PHOSPHONOCROTONATE
CAS No.
10236-14-3
Chemical Name
TRIETHYL 4-PHOSPHONOCROTONATE
Synonyms
Ethyl 4-(diethoxyphosphoryl);TRIETHYL 4-PHOSPHONOCROTONATE;TRIETHYL 4-PHOSPHONO-2-BUTENOATE;triethyl trans-4-phosphono-2-butenoate;4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER;Ethyl 4-(diethoxyphosphinyl)-2-butenoate;TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE;triethyl 4-phosphonocrotonate, cis + trans;(E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate;Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate
CBNumber
CB1664375
Molecular Formula
C10H19O5P
Formula Weight
250.23
MOL File
10236-14-3.mol
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TRIETHYL 4-PHOSPHONOCROTONATE Property

Boiling point:
135 °C0.4 mm Hg(lit.)
Density 
1.128 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.455(lit.)
Flash point:
>230 °F
form 
Liquid
color 
Clear light yellow
CAS DataBase Reference
10236-14-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
116092
Product name
Triethyl 4-phosphonocrotonate, mixture of isomers
Purity
technical grade, 90%
Packaging
10g
Price
$109
Updated
2024/03/01
Alfa Aesar
Product number
A10995
Product name
Triethyl 4-phosphonocrotonate, cis + trans, 94%
Packaging
10g
Price
$91.65
Updated
2024/03/01
Alfa Aesar
Product number
A10995
Product name
Triethyl 4-phosphonocrotonate, cis + trans, 94%
Packaging
25g
Price
$172.65
Updated
2024/03/01
Alfa Aesar
Product number
A10995
Product name
Triethyl 4-phosphonocrotonate, cis + trans, 94%
Packaging
250g
Price
$1389
Updated
2021/12/16
AK Scientific
Product number
7628AC
Product name
Triethyl4-phosphonocrotonate
Packaging
25g
Price
$263
Updated
2021/12/16
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TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties,Usage,Production

Chemical Properties

CLEAR LIGHT YELLOW LIQUID

Uses

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Uses

Reactant for:

  • Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
  • Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
  • Orally bioavailable GPR40 agonist synthesis
  • Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
  • Preaparation of mGlu4R agonists
  • Dearomatizing cyclization of nicotinyl-substituted esters and ketones

reaction suitability

reaction type: C-C Bond Formation

TRIETHYL 4-PHOSPHONOCROTONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIETHYL 4-PHOSPHONOCROTONATE Suppliers

Belgium 1 China 35 France 1 Germany 2 India 5 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 62
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74

10236-14-3, TRIETHYL 4-PHOSPHONOCROTONATERelated Search:

TRIETHYL 4-PHOSPHONOBUTYRATE TRIETHYL 3-PHOSPHONOPROPIONATE Dimethyl methylphosphonate DIMETHYL ETHYLPHOSPHONATE DIETHYL ALLYLPHOSPHONATE Methyldiethoxyphosphine DIMETHYL ALLYLPHOSPHONATE ETHYL METHYLPHOSPHONIC ACID METHYLPHOSPHONIC ACID ETHYLPHOSPHONIC ACID TRIETHYL 4-PHOSPHONOCROTONATE DIMETHYL ETHYLPHOSPHONITE DIETHYL ETHYLPHOSPHONATE Diethyl methylphosphonate TRIMETHYL 4-PHOSPHONOCROTONATE TRIETHYL 3-METHYL-4-PHOSPHONOCROTONATE ETHYL HYDROGEN ETHYLPHOSPHONATE ALLYLPHOSPHONIC ACID

  • 4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER
  • TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE
  • TRIETHYL 4-PHOSPHONO-2-BUTENOATE
  • TRIETHYL 4-PHOSPHONOCROTONATE
  • TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS
  • Triethyl 4-phosphonocrotonate, predominantly trans, 92%
  • triethyl 4-phosphonocrotonate, cis + trans
  • triethyl 4-phosphonocrotonate, mixture of isomers
  • triethyl trans-4-phosphono-2-butenoate
  • Triethyl 4-phosphonocrotonate, cis + trans, tech. 90%
  • Triethyl 4-phosphonocrotonate, 92%, predominantly trans
  • (E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate
  • Ethyl 4-(diethoxyphosphoryl)but-2-enoate, Ethyl 4-(diethylphosphono)crotonate
  • Triethyl 4-phosphonocrotonate, predoMinantly trans, 92% 50GR
  • Triethyl 4-phosphonocrotonate, mixture of isomers technical grade, 90%
  • Triethyl 4-phosphonocrotonate, cis and trans, technical, 90%
  • Ethyl 4-(diethoxyphosphoryl)
  • 2-Butenoic acid, 4-(diethoxyphosphinyl)-, ethyl ester
  • Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate
  • Ethyl 4-(diethoxyphosphinyl)-2-butenoate
  • 10236-14-3
  • C2H5O2POCH2CHCHCO2C2H5
  • C10H19O5P
  • C-C Bond Formation
  • Horner-Wadsworth-Emmons Reagents
  • Olefination
  • Synthetic Reagents
  • C-C Bond Formation
  • Horner-Wadsworth-Emmons Reagents
  • Olefination