4-BROMOCROTONIC ACID

Product Name: 4-BROMOCROTONIC ACID
CAS No.: 13991-36-1
Chemical Name: 4-BROMOCROTONIC ACID
Synonyms: 4-bromocrotonic aci;4-BROMOCROTONIC ACID;r-bromocrotonic acid;Remazolam impurity 4;Neratinib Impurity 25;Remimazolam Impurity 4;4-BroMobut-2-enoic acid;gamma-Bromocrotonic acid;(E)-4-Bromocrotonic acid;4-Bromocrotonic Acid >
CBNumber: CB1669800
Molecular Formula: C4H5BrO2
Formula Weight: 164.99
MOL File: 13991-36-1.mol

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4-BROMOCROTONIC ACID Property

Melting point:: 74 °C
Boiling point:: 288℃
Density: 1.718
Flash point:: 128℃
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 4.13±0.10(Predicted)
color: Pale Yellow to Pale Beige
InChI: InChI=1S/C4H5BrO2/c5-3-1-2-4(6)7/h1-2H,3H2,(H,6,7)/b2-1+
InChIKey: DOTGZROJTAUYFQ-OWOJBTEDSA-N
SMILES: C(O)(=O)/C=C/CBr
CAS DataBase Reference: 13991-36-1

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Safety

Risk Statements: 34
Safety Statements: 36/37/39
RIDADR: 3261
HazardClass: 8
PackingGroup: III
HS Code: 29161900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2298
Product name: 4-Bromocrotonic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $199
Updated: 2025/07/31

TCI Chemical

Product number: B2298
Product name: 4-Bromocrotonic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $597
Updated: 2025/07/31

TRC

Product number: B682580
Product name: (E)-4-BromocrotonicAcid
Packaging: 5g
Price: $525
Updated: 2021/12/16

TRC

Product number: B682580
Product name: (E)-4-BromocrotonicAcid
Packaging: 1g
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 180966
Product name: (E)-4-Bromobut-2-enoic acid
Purity: 95%+
Packaging: 1g
Price: $150
Updated: 2021/12/16

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4-BROMOCROTONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

(E)-4-Bromocrotonic Acid acts as a fatty acid blocking agent. It is used to selectively adjust levels of long-chain acyl CoA and carnitine in aerobic and ischemic myocardium. It is also an intermediate used to prepare tetrahydropyridothienopyrimidine derivatve with antiproliferative activities.

Synthesis

107-93-7

13991-36-1

General procedure for the synthesis of (E)-4-bromobut-2-enoic acid from crotonic acid: a mixture of (E)-but-2-enoic acid (10.00 g, 116.16 mmol), N-bromosuccinimide (NBS, 1.02 g, 118.48 mmol), and 2,2'-azobis(2-methylpropionitrile) (AIBN, 381.49 mg, 2.32 mmol ) were dissolved in carbon tetrachloride (CCl4, 120 mL) and the reaction was stirred at 90 °C for 4 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The residue was recrystallized with hexane to afford the target product (E)-4-bromobut-2-enoic acid (19.17 g, 42.2% yield).

References

[1] Archiv der Pharmazie, 2014, vol. 347, # 8, p. 552 - 558
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2366 - 2378
[3] Patent: CN107556289, 2018, A. Location in patent: Paragraph 0112; 0114; 0115; 0116
[4] Journal of Organic Chemistry, 2011, vol. 76, # 11, p. 4467 - 4481
[5] Tetrahedron Letters, 2018, vol. 59, # 18, p. 1776 - 1778

4-BROMOCROTONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMOCROTONIC ACID Suppliers

Americas 1 China 178 Europe 1 Germany 1 India 16 Japan 1 United Kingdom 4 United States 13 Global 215

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View Lastest Price from 4-BROMOCROTONIC ACID manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: 4-BROMOCROTONIC ACID 13991-36-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-03

Hebei Best Biological Technology Co., Ltd

Product: 4-bromocrotonic acid 13991-36-1
Price: US $200.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 1000t/month
Release date: 2022-11-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMOCROTONIC ACID 13991-36-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

13991-36-1, 4-BROMOCROTONIC ACIDRelated Search:

4-Bromomethyl-7-methoxycoumarin 5-Bromo-2-hydroxynicotinic acid ETHYL 4-BROMO-3-ETHOXY-2-BUTENOATE 4-Bromocrotonic acid phenacyl ester,4-Bromocrotonic acid benzoylmethyl ester 4-BROMOCROTONIC ACID METHYL ESTER,methyl 4-bromocrotonate (4-bromocrotonic acid methyl ester) 4-BROMOCROTONIC ACID METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ETHYL 4-BROMOCROTONATE (4-BROMOCROTONIC ACID ETHYL ESTER),4-BROMOCROTONIC ACID ETHYL ESTER 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN 4-BROMOCROTONIC ACID METHYL ESTER 2-Methylbenzyl chloride 7-ACETOXY-4-BROMOMETHYLCOUMARIN 5-BROMO-1-(3-FLUOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID 5-BROMO-1-(2,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID 5-BROMO-2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID 1-BENZYL-5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID 3-Bromocrotonic acid 2-Bromocrotonic acid

TRANS-4-BROMO-2-BUTENOIC ACID

2-Butenoic acid, 4-bromo-, (E)-

4-BroMobut-2-enoic acid

(2E)-4-Bromo-2-butenoic acid

2-Butenoic acid,4-broMo-, (2E)-

(E)-4-Bromo-2-butenoic acid

(E)-4-Bromocrotonic acid

r-bromocrotonic acid

4-BROMOCROTONIC ACID

Remimazolam Impurity 4

gamma-Bromocrotonic acid

gamma-Bromocrotonic acid, tech

4-Bromocrotonic acid - min 98%

4-Bromocrotonic Acid &gt

4-bromocrotonic aci

Neratinib Impurity 25

Remazolam impurity 4

4-bromocrotonic Acid CAS NO.13991-36-1

13991-36-1