5-Bromo-2-hydroxynicotinic acid
- Product Name
- 5-Bromo-2-hydroxynicotinic acid
- CAS No.
- 104612-36-4
- Chemical Name
- 5-Bromo-2-hydroxynicotinic acid
- Synonyms
- CAS:104612-36-4;5-Bromo-2-hydroxynic;5-BroMo-2-hydroxynicotini...;2-Hydroxy-5-bromonicotinic acid;5-BROMO-2-HYDROXYNICOTINIC ACID;2-hydroxy-5-bromononicotinic acid;5-BROMO-3-CARBOXY-2(1H)-PYRIDINONE;5-Bromo-2-hydroxynicotinic acid 98%;5-Bromo-2-hydroxynicotinic Acid >5-Bromo-2-hydroxynicotinic acid ,98%
- CBNumber
- CB4453444
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 104612-36-4.mol
5-Bromo-2-hydroxynicotinic acid Property
- Melting point:
- 287°C
- Boiling point:
- 354.7±42.0 °C(Predicted)
- Density
- 2.015±0.06 g/cm3(Predicted)
- Flash point:
- 287°C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.09±0.20(Predicted)
- form
- powder to crystal
- color
- Light orange to Yellow to Green
- Decomposition
- 287 ºC
- InChI
- InChI=1S/C6H4BrNO3/c7-3-1-4(6(10)11)5(9)8-2-3/h1-2H,(H,8,9)(H,10,11)
- InChIKey
- GYXOTADLHQJPIP-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(Br)C=C1C(O)=O
- CAS DataBase Reference
- 104612-36-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B3729
- Product name
- 5-Bromo-2-hydroxynicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B3729
- Product name
- 5-Bromo-2-hydroxynicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- B696220
- Product name
- 5-Bromo-2-hydroxynicotinic Acid
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B696220
- Product name
- 5-Bromo-2-hydroxynicotinic Acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 045185
- Product name
- 5-Bromo-2-oxo-1,2-dihydropyridine-3-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $12
- Updated
- 2021/12/16
5-Bromo-2-hydroxynicotinic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal
Synthesis Reference(s)
Synthetic Communications, 19, p. 553, 1989 DOI: 10.1080/00397918908050699
Synthesis, p. 528, 2002 DOI: 10.1055/s-2002-20959
Synthesis
609-71-2
104612-36-4
General procedure for the synthesis of 5-bromopyridine-3-carboxylic acid-2-one from 2-hydroxynicotinic acid: the compound was prepared according to the method of Y.S. Lo (Synthetic Communications, 1989, 553). Bromine (0.77 eq.) was slowly added dropwise to a stirred solution of 50% NaOH (2.4 eq.) in water (1 M solution) at 0 °C. After 5 min, 50% NaOH (3 eq.) was appended to the mixture, followed by the addition of solid 2-hydroxynicotinic acid (1 eq.) and the resultant solution was stirred continuously at 50 °C. After 20 h, a mixture of bromine ( 0.38 eq.) and a pre-prepared solution of 50% NaOH (1.2 eq.) in water (1 M solution) and continued stirring at 50 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and acidified to pH 2 with concentrated hydrochloric acid to precipitate the solid product. The solid was separated by filtration, washed sequentially with warm water/isopropanol (3:1) and ether, and dried to give 5-bromo-2-hydroxynicotinic acid in 87% yield as an off-white solid. The product characterization data were as follows: 1H NMR (400 MHz, DMSO) δ 8.25 (1H, d, J = 2.7 Hz), 8.33 (1H, d, J = 2.7 Hz), 13.84 (2H, bs); 13C NMR (400 MHz, DMSO) δ 99.45, 117.97, 142.01, 147.42, 163.22, 163.88; MS (ES-) m/z 218-216 (M-H)-.
References
[1] Patent: WO2004/110442, 2004, A1. Location in patent: Page 17; 18
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2566 - 2569
[3] Patent: US2002/161000, 2002, A1
[4] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 26
[5] Organic Process Research and Development, 2008, vol. 12, # 4, p. 603 - 613
5-Bromo-2-hydroxynicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-hydroxynicotinic acid Suppliers
- Tel
- 0519-89891966 13906113265
- 986329407@qq.com
- Country
- China
- ProdList
- 51
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
View Lastest Price from 5-Bromo-2-hydroxynicotinic acid manufacturers
- Product
- 5-Bromo-2-hydroxynicotinic acid 104612-36-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 5-Bromo-2-hydroxynicotinic acid 104612-36-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 5-Bromo-2-hydroxynicotinic acid 104612-36-4
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08