2-BROMO-1-FLUORO-4-IODOBENZENE
- Product Name
- 2-BROMO-1-FLUORO-4-IODOBENZENE
- CAS No.
- 811842-30-5
- Chemical Name
- 2-BROMO-1-FLUORO-4-IODOBENZENE
- Synonyms
- 2-Bromo-4-iodofluorobenzene;3-BROMO-4-FLUORO IODOBENZENE;3-bromo-4-fluoro-1-iodobenzene;1-Bromo-2-fluoro-5-iodobenzene;2-BROMO-1-FLUORO-4-IODOBENZENE;3-Bromo-4-fluoroiodobenzene 98%;Benzene,2-broMo-1-fluoro-4-iodo-;2-BROMO-1-FLUORO-4-IODOBENZENE ISO 9001：2015 REACH
- CBNumber
- CB1670789
- Molecular Formula
- C6H3BrFI
- Formula Weight
- 300.89
- MOL File
- 811842-30-5.mol
2-BROMO-1-FLUORO-4-IODOBENZENE Property
- Boiling point:
- 243℃
- Density
- 2.281
- Flash point:
- 101℃
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Light yellow to light brown Liquid
- InChI
- InChI=1S/C6H3BrFI/c7-5-3-4(9)1-2-6(5)8/h1-3H
- InChIKey
- LHRMBQARSBULRX-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(I)C=C1Br
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B692308
- Product name
- 2-Bromo-1-fluoro-4-iodobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B692308
- Product name
- 2-Bromo-1-fluoro-4-iodobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B692308
- Product name
- 2-Bromo-1-fluoro-4-iodobenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 1600-U-05
- Product name
- 2-Bromo-1-fluoro-4-iodobenzene
- Purity
- 98%
- Packaging
- 25g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FB67663
- Product name
- 2-Bromo-1-fluoro-4-iodobenzene
- Packaging
- 250g
- Price
- $200
- Updated
- 2021/12/16
2-BROMO-1-FLUORO-4-IODOBENZENE Chemical Properties,Usage,Production
Chemical Properties
light yellow liquid
Synthesis
656-64-4
811842-30-5
The general procedure for the synthesis of 2-bromo-1-fluoro-4-iodobenzene from 3-bromo-4-fluoroaniline is as follows: in a 1L four-necked round-bottomed flask equipped with a stirrer, a Liebig condenser, a 100mL dropping funnel, and a thermometer, 630mL of water, 84mL (0.926mol) of concentrated hydrochloric acid, and 54.7g (0.241 mol) of 3-bromo-4-fluoroaniline were added at room temperature and stirred for 24 hours. Subsequently, the reaction mixture was cooled to -10 °C with an ice-water bath and 19.0 g (0.270 mol) of sodium nitrite in 63 mL of aqueous solution was slowly added dropwise, controlling the temperature not to exceed 5 °C during the dropwise addition. After the dropwise addition was completed, stirring was continued at 5 °C or lower for 30 min, and the reaction solution was filtered through a filter aid to obtain an aqueous solution of the diazonium salt. In another 2L four-necked round-bottomed flask equipped with a stirrer, an Erlenmeyer condenser, a 1L dropping funnel, and a thermometer, 42.0 g (0.251 mol) of potassium iodide and 125 mL of water were added, and the mixture was cooled to 10°C and stirred. Subsequently, the aqueous diazonium salt solution prepared above was slowly added dropwise. Upon completion of the dropwise addition, the ice water bath was removed and the reaction mixture was allowed to warm naturally to room temperature, then heated to 40 °C and stirred at that temperature for 4 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, 270 mL of dichloromethane (DCM) was added, and transferred to a 2L dispensing funnel to separate the aqueous layer. The aqueous layer was extracted with 220 mL of DCM, and the organic layer was combined and washed three times with 220 mL of 20% aqueous sodium thiosulfate, 220 mL of saturated saline, and 220 mL of water, in that order. The organic layer was dried over anhydrous magnesium sulfate, filtered to remove the desiccant, and distilled under reduced pressure to remove the solvent to obtain the crude product. The crude product was purified by silica gel column chromatography with n-heptane as the unfolding agent, and 62.5 g (86.0% yield) of 2-bromo-1-fluoro-4-iodobenzene was finally obtained.
References
[1] Patent: JP2018/90561, 2018, A. Location in patent: Paragraph 0088
[2] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 45
2-BROMO-1-FLUORO-4-IODOBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-1-FLUORO-4-IODOBENZENE manufacturers
- Product
- 2-BROMO-1-FLUORO-4-IODOBENZENE 811842-30-5
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 2-BROMO-1-FLUORO-4-IODOBENZENE 811842-30-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07