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(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID

Product Name
(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID
CAS No.
5709-98-8
Chemical Name
(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID
Synonyms
(R)-3-Cyclohexene-1-carboxylic acid;(R)-Cyclohex-3-enecarboxylic acid;EOS-61457;(R) -3-cyclohexenoic acid;(R)-3-cyclohexene-1-carboxylic;(R)-3-CyclohexenecarboxylicAci;(R)-cyclohex-3-ene-1-carboxylicacid;(R)-3-Cyclohexene-1β-carboxylic acid;(1R)-3-Cyclohexene-1-carboxylic acid;(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID
CBNumber
CB1673391
Molecular Formula
C7H10O2
Formula Weight
126.15
MOL File
5709-98-8.mol
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(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID Property

Boiling point:
90 °C(Press: 0.2 Torr)
Density 
1.126±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Methanol
form 
Oil
pka
4.67±0.20(Predicted)
color 
Colorless
optical activity
127.898°(C=1g/100ml CHCL3)
InChI
InChI=1S/C7H10O2/c8-7(9)6-4-2-1-3-5-6/h1-2,6H,3-5H2,(H,8,9)/t6-/m0/s1
InChIKey
VUSWCWPCANWBFG-LURJTMIESA-N
SMILES
[C@@H]1(C(O)=O)CCC=CC1
CAS DataBase Reference
5709-98-8
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN3265
HazardClass 
8
HS Code 
2916200090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C987885
Product name
(R)-3-CyclohexenecarboxylicAcid
Packaging
25mg
Price
$160
Updated
2021/12/16
TRC
Product number
C987885
Product name
(R)-3-CyclohexenecarboxylicAcid
Packaging
100mg
Price
$595
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20702
Product name
(R)-3-Cyclohexenecarboxylic acid
Packaging
5G
Price
$975
Updated
2021/12/16
Apolloscientific
Product number
OR922857
Product name
(R)-(+)-3-Cyclohexenecarboxylicacid
Purity
98%
Packaging
100g
Price
$1073
Updated
2021/12/16
Matrix Scientific
Product number
122285
Product name
(R)-(+)-3-Cyclohexenecarboxylicacid
Purity
97.0%
Packaging
5g
Price
$129
Updated
2021/12/16
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(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Colorless Oil

Uses

An intermediate of Leustroducsin B (LSN-B), a novel colony-stimulating factor (CSF) inducer, which was isolated from Streptomyces platensis.

Synthesis

6493-77-2

5709-98-8

Synthesis of Intermediate IV: Porcine liver esterase (PLE, 51.2 mg, 1382 units) was added to a stirred suspension of methyl 3-cyclohexene-1-carboxylate (III, 5.19 g, 37.0 mmol) in pH 7.00 phosphate buffer solution (520 mL, 0.07 M). The pH of the reaction system was maintained at 7.00 by dropwise addition of NaOH solution (1.0 M) via syringe pump.The reaction was stirred continuously at room temperature until 1 equivalent of NaOH (37 mL) was consumed (reaction time: 11 h, TLC monitoring of the unfolding agent: petroleum ether/ether, 1:1). The reaction mixture was transferred to a dispensing funnel and washed twice with ethyl acetate (2 × 300 mL). After separating the phases, the organic phase was back-extracted twice with pH 7.00 phosphate buffer solution (2 × 300 mL). The aqueous phases were combined and acidified to pH 2 with aqueous HCl (30 mL, 4 M), followed by three extractions with ethyl acetate (3 × 400 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure (100 mbar). The crude product was filtered through a short silica gel column to afford (R)-3-cyclohexenecarboxylic acid (IV) as a light yellow oil (3.92 g, 84% yield). The enantiomeric excess values of the product were 96.3% ee (GC assay), 94.3% ee (spin assay), [α]D21 +89.12° (c = 6.730, methanol) (literature value: +94.5° (c = 7, methanol), [Acta Chem. Scand., 1970, 24, 2693]).

References

[1] Patent: US2008/161546, 2008, A1. Location in patent: Page/Page column title page; 18
[2] Chemistry - A European Journal, 2012, vol. 18, # 5, p. 1342 - 1351
[3] Patent: US2008/200406, 2008, A1. Location in patent: Page/Page column 25; sheet 1
[4] Patent: US2011/251148, 2011, A1. Location in patent: Page/Page column 9
[5] Patent: WO2012/61662, 2012, A1. Location in patent: Page/Page column 60

(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID Suppliers

Canada 1 China 174 India 3 United Kingdom 2 United States 15 Global 195
Sunyan Biotech (Heze) Co.,Ltd
Tel
19256007915 19256007915
Email
375811307@qq.com
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China
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Zhengzhou Kangshan Biological Co., Ltd.
Tel
+86-0371-55023472 +86-13663848272
Fax
0371-55023472
Email
2584787837@qq.com
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China
ProdList
260
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58
ZhengZhou Yimi Pharma R&D Co.,LTD.
Tel
15393710992
Email
375000787@QQ.com
Country
China
ProdList
21
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58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Email
wtx@bayeebio.com
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China
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239
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Anhui heavy sky biological technology Co., LTD
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15556773118
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3848575348@qq.com
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China
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56
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58
Jinan Kabotang Biological Technology Co.,Ltd.
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0531-61320525 15866703830
Email
figo.gao@foxmail.com
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China
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5178
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Beijing HwrkChemical Technology Co., Ltd
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18515581800 18501085097
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010-89508210
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sales.bj@hwrkchemical.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
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sales8178@energy-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
Fax
0573-85285100
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isenchem@163.com
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China
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View Lastest Price from (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID 5709-98-8
Price
US $980.00-750.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-15
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-3-Cyclohexene-1-carboxylic acid 5709-98-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Zhengzhou Anbu Chem Co.,Ltd
Product
(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID 5709-98-8
Price
US $0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
1000KGS
Release date
2023-06-13

5709-98-8, (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACIDRelated Search:

4,10-DIOXATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE Methyl-5-norbornene-2,3-dicarboxylic anhydride TRANS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID 6-Methoxycarbonyl-3-cyclohexene-1-carboxylic acid EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE 1,2,3,6-Tetrahydro-4-methylphthalic anhydride CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID Carbic anhydride MONO-METHYL CIS-5-NORBORNENE-ENDO-2,3-DICARBOXYLATE cis-1,2,3,6-Tetrahydrophthalic anhydride ENDO-BICYCLO[2.2.2]OCT-5-ENE-2,3-DICARBOXYLIC ANHYDRIDE 5-Norbornene-2,3-dicarboxylic acid (3R,4S,5R)-3,4,5-TRIHYDROXY-1-CYCLOHEXENECARBOXYLIC ACID 1-CYCLOHEXENECARBOXYLIC ACID (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID 3-CYCLOHEXENECARBOXYLIC ACID,3-CYCLOHEXENECARBOXYLIC ACID,98%,delta3-Cyclohexenecarboxylic acid,delta(Sup3)-Cyclohexenecarboxylic acid ETHYL CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLATE HYDROCHLORIDE

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  • (R)-cyclohex-3-ene-1-carboxylicacid
  • (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID
  • (1R)-3-Cyclohexene-1-carboxylic acid
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  • (R)-3-Cyclohexene-1β-carboxylic acid
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  • (R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID ISO 9001：2015 REACH
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  • (R) -3-cyclohexenoic acid
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