2,6-Dibromo-3-nitropyridine
- Product Name
- 2,6-Dibromo-3-nitropyridine
- CAS No.
- 55304-80-8
- Chemical Name
- 2,6-Dibromo-3-nitropyridine
- Synonyms
- 2,6-Dibromo-3-Nitropridine;2,6-DIBROMO-3-NITRO-PYRIDINE;2,6-dibromo-3-nitro-pryridine;Pyridine, 2,6-dibromo-3-nitro-;2,6-Dibromo-3-nitropyridine ,98%
- CBNumber
- CB1673412
- Molecular Formula
- C5H2Br2N2O2
- Formula Weight
- 281.89
- MOL File
- 55304-80-8.mol
2,6-Dibromo-3-nitropyridine Property
- Melting point:
- 78 °C
- Boiling point:
- 295.8±35.0 °C(Predicted)
- Density
- 2?+-.0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -7.68±0.10(Predicted)
- color
- Dark Yellow
- InChI
- InChI=1S/C5H2Br2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H
- InChIKey
- FFRFTURYWWFKIC-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(Br)=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 55304-80-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D426045
- Product name
- 2,6-Dibromo-3-nitropyridine
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-W000354
- Product name
- 2,6-Dibromo-3-nitropyridine
- Purity
- 98.87%
- Packaging
- 25g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- CS-W000354
- Product name
- 2,6-Dibromo-3-nitropyridine
- Purity
- 98.87%
- Packaging
- 100g
- Price
- $223
- Updated
- 2021/12/16
- Product number
- FD11914
- Product name
- 2,6-Dibromo-3-nitropyridine
- Packaging
- 50g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FD11914
- Product name
- 2,6-Dibromo-3-nitropyridine
- Packaging
- 100g
- Price
- $440
- Updated
- 2021/12/16
2,6-Dibromo-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Yellow powder
Uses
2,6-Dibromo-3-nitropyridine is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the synthesis of amino(carbamoylmethyl) pyridones as factor VIIa inhibitors and anticoagulants.
Synthesis
16013-85-7
55304-80-8
The general procedure for the synthesis of 2,6-dibromo-3-nitropyridine from 2,6-dichloro-3-nitropyridine was as follows (Intermediate 6: 2,6-dibromo-3-nitropyridine, Scheme 12): Commercially available 2,6-dichloro-3-nitropyridine (10.0 g, 51.8 mmol) was mixed with a 33% HBr/AcOH solution (120 mL) and heated at 80°C. The reaction was carried out for 3 hours. The reaction was heated at 80°C for 3 hours. After completion of the reaction, the reaction solution was concentrated in vacuum. The resulting residue was dissolved in EtOAc and washed with saturated aqueous sodium bicarbonate. The organic phase was dried over anhydrous sodium sulfate and concentrated again under vacuum. The final product 2,6-dibromo-3-nitropyridine 14.4 g (99% yield) was obtained, which can be used as intermediate 6 without further purification. The product was analyzed by GC/MS showing a purity of 94% with a retention time (tR) of 7.56 min (tR of raw material was 6.93 min), and the characteristic peaks of the mass spectra (m/z) were 280/282/284 (M, 38%), 222/224/226 (35%), and 76 (100%), and the detection instrument was Finnegan LCQ.
References
[1] Patent: WO2006/24666, 2006, A1. Location in patent: Page/Page column 52
[2] Patent: WO2011/116176, 2011, A1. Location in patent: Page/Page column 70-71
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6813 - 6817
[4] Patent: WO2005/75478, 2005, A1. Location in patent: Page/Page column 28
[5] Patent: EP1787991, 2007, A1. Location in patent: Page/Page column 36-37
2,6-Dibromo-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dibromo-3-nitropyridine manufacturers
- Product
- 2,6-Dibromo-3-nitropyridine 55304-80-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-11
- Product
- 2,6-Dibromo-3-nitropyridine 55304-80-8
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- 2,6-Dibromo-3-nitropyridine 55304-80-8
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-11-26