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1-(5-Nitropyridin-2-yl)piperazine

Product Name
1-(5-Nitropyridin-2-yl)piperazine
CAS No.
82205-58-1
Chemical Name
1-(5-Nitropyridin-2-yl)piperazine
Synonyms
Palbociclib Impurity 43;5-Nitro-2-piperazinopyridine;1-(5-NITROPYRIDIN-2-YL)PIPERAZINE;1-(5-nitro-2-pyridinyl)-piperazine;Piperazine, 1-(5-nitro-2-pyridinyl)-;1-(5-Nitropyridin-2-yl)piperazine95%;1-(5-Nitropyridin-2-yl)piperazine 95%;1-(5-Nitropyridin-2-yl)piperazine - [N93582];1-(5-Nitropyridin-2-yl)piperazine AldrichCPR;1-(5-nitro-2-pyridinyl)piperazine hydrochloride
CBNumber
CB1674419
Molecular Formula
C9H12N4O2
Formula Weight
208.22
MOL File
82205-58-1.mol
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1-(5-Nitropyridin-2-yl)piperazine Property

Melting point:
84-85 °C
Boiling point:
418.1±40.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
8.42±0.10(Predicted)
Appearance
Light yellow to yellow Solid
CAS DataBase Reference
82205-58-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
N901378
Product name
1-(5-Nitro-2-pyridinyl)piperazine
Packaging
2.5g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
024425
Product name
1-(5-Nitropyridin-2-yl)piperazine
Packaging
500mg
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
024425
Product name
1-(5-Nitropyridin-2-yl)piperazine
Packaging
1g
Price
$24
Updated
2021/12/16
SynQuest Laboratories
Product number
4H55-1-W4
Product name
1-(5-Nitropyridin-2-yl)piperazine
Purity
95.0%
Packaging
500mg
Price
$48
Updated
2021/12/16
AK Scientific
Product number
W8609
Product name
1-(5-Nitropyridin-2-yl)piperazine
Packaging
500mg
Price
$71
Updated
2021/12/16
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1-(5-Nitropyridin-2-yl)piperazine Chemical Properties,Usage,Production

Synthesis

193902-78-2

82205-58-1

Step 2: Synthesis of 1-(5-nitropyridin-2-yl)piperazine (B-3) Compound 1-tert-butylcarbonyl-4-(5-nitro-2-piperidinyl)piperazine (B-2, 19.45 g, 0.0631 mol) was dissolved in dichloromethane (250 mL) and cooled to 0°C. Trifluoroacetic acid (50 mL) was added slowly. The reaction mixture was stirred at room temperature for 16 hours and then concentrated under reduced pressure. The crude product was again dissolved in dichloromethane (250 mL), and the pH was adjusted to alkaline by sequentially adding 1N aqueous NaOH solution (200 mL) and 3N aqueous NaOH solution (100 mL). The organic layer was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1-(5-nitropyridin-2-yl)piperazine (B-3, 13.13 g, 100% yield) as a yellow solid. Mass spectrometry (MS) showed the [M + 1] peak as 209.

References

[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 182
[2] Patent: WO2011/31628, 2011, A1. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 4, p. 985 - 988
[4] Tetrahedron Letters, 2011, vol. 52, # 45, p. 5905 - 5909
[5] Patent: WO2006/94840, 2006, A1. Location in patent: Page/Page column 43-44

1-(5-Nitropyridin-2-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Nitropyridin-2-yl)piperazine Suppliers

China 69 France 2 Germany 2 India 3 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 3 United States 19 Global 101
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 1-(5-Nitropyridin-2-yl)piperazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Dideu Industries Group Limited
Product
1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-07
Career Henan Chemical Co
Product
1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

82205-58-1, 1-(5-Nitropyridin-2-yl)piperazineRelated Search:

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