1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE

Product Name: 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
CAS No.: 193902-78-2
Chemical Name: 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
Synonyms: Palbociclib Impurity 102;Palbociclib Impurity SMA-7;1-Boc-4-(5-nitro-2-pyridinyl)-piperazine;1-Boc-4-(5-nitro-2-pyridyl)piperazine 97%;tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate;1-(tert-Butyloxycarbonyl)-4-(5-nitropyridin-2-yl)piperazine;4-(5-nitro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester;1-Boc-4-(5-nitro-2-pyridyl)piperazine;1-Piperazinecarboxylic acid, 4-(5-nitro-2-pyridinyl)-, 1,1-dimethylethyl ester;1-tert-Butoxycarbonyl-4-(5-nitropyrid-2-yl)piperazine, 2-(4-Boc-1-piperazinyl)-5-nitropyridine
CBNumber: CB5973088
Molecular Formula: C14H20N4O4
Formula Weight: 308.33
MOL File: 193902-78-2.mol

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1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Property

Melting point:: 168-172 °C (lit.)
Boiling point:: 468.7±45.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
pka: 4.38±0.29(Predicted)
form: solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654191
Product name: 1-Boc-4-(5-nitro-2-pyridyl)piperazine
Purity: 97%
Packaging: 10g
Price: $263
Updated: 2023/06/20

TRC

Product number: B700425
Product name: tert-Butyl4-(5-Nitropyridin-2-yl)piperazine-1-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-735
Product name: tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate
Purity: 97.0%
Packaging: 1g
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139711
Product name: tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate
Packaging: 10g
Price: $112.5
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-735
Product name: tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate
Purity: 97.0%
Packaging: 5G
Price: $190
Updated: 2021/12/16

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1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

4487-59-6

57260-71-6

193902-78-2

General procedure: 2-bromo-5-nitropyridine (11.39 g, 56.1 mmol), tetrabutylammonium iodide (TBAI) (1.04 g, 0.05 mmol), potassium carbonate (8.53 g, 61.7 mmol), and N-BOC-piperazine (11.5 g, 61.7 mmol) were dissolved in DMSO (100 mL) and gently heated to 50 °C. The reaction was carried out for 3 h, followed by cooling to room temperature overnight. The reaction mixture was diluted with EtOAc (200 mL), filtered to remove the salt, and the DMSO solution was obtained by evaporating the EtOAc. The solution was diluted with water to form a precipitate. The precipitate was collected by filtration, washed with water and dried under vacuum to give 1-tert-butylcarbonyl-4-(5-nitro-2-pyridyl)piperazine (16.1 g, 93%) as a light orange solid.1H NMR (400 MHz, CDCl3) δ ppm 1.47 (s, 9H), 3.55 (m, 4H), 3.75 (m, 4H), 6.55 (d, J = 9.3 Hz, 1H), 8.21 (dd, J = 9.5, 2.7 Hz, 1H), 9.03 (d, J = 2.7 Hz, 1H). 1-tert-butylcarbonyl-4-(5-nitro-2-pyridinyl)piperazine (16.0 g, 51.9 mmol) was dissolved in THF (400 mL), Raney nickel (4 g) was added, and the reaction was carried out for 5 hr under 50 psi hydrogen atmosphere. The catalyst was removed by diatomaceous earth filtration and the solvent was evaporated in vacuum to give 1-tert-butylcarbonyl-4-(5-amino-2-pyridyl)piperazine (14.5 g, 100%).1H NMR (400 MHz, CDCl3) δ ppm 1.46 (s, 9H), 3.31 (m, 6H), 3.53 (m, 4H), 6.56 (d, J = 8.8 Hz. 1H), 6.98 (dd, J = 8.8, 2.9 Hz, 1H), 7.78 (dd, J = 2.9, 0.7 Hz, 1H). m/z 279.1 (M + 1).

References

[1] Patent: US2005/182078, 2005, A1. Location in patent: Page/Page column 9; 12
[2] Tetrahedron Letters, 2011, vol. 52, # 45, p. 5905 - 5909
[3] Patent: WO2004/9587, 2004, A1. Location in patent: Page 36
[4] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0753; 0754
[5] Patent: US2004/9988, 2004, A1. Location in patent: Page/Page column 10

1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Suppliers

China 67 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 77

Adamas Reagent, Ltd.

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193902-78-2, 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINERelated Search:

tert-butyl (4,6-dichloropyridin-3-yl)carbaMate tert-Butyl N-(((4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)methyl)carbamate tert-Butyl 3-(2-hydroxyethoxy)propanoate 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-(2-pyridinyl)-piperazine 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib Impurity V 1-(6-nitropyridin-3-yl)piperazine tert-butyl 4-(3-nitropyridin-4-yl)piperazine-1-carboxylate 4-(6-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester 1-BOC-4-(3-AMINO-4-PYRIDINYL)-PIPERAZINE 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 2324831-15-2 INDEX NAME NOT YET ASSIGNED 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester Palbociclib Impurity 61 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine

1-Boc-4-(5-nitro-2-pyridinyl)-piperazine

4-(5-nitro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

1-tert-Butoxycarbonyl-4-(5-nitropyrid-2-yl)piperazine, 2-(4-Boc-1-piperazinyl)-5-nitropyridine

1-Piperazinecarboxylic acid, 4-(5-nitro-2-pyridinyl)-, 1,1-dimethylethyl ester

1-Boc-4-(5-nitro-2-pyridyl)piperazine 97%

Palbociclib Impurity SMA-7

Palbociclib Impurity 102

1-(tert-Butyloxycarbonyl)-4-(5-nitropyridin-2-yl)piperazine

1-Boc-4-(5-nitro-2-pyridyl)piperazine

193902-78-2