tert-Butyl 3-(2-hydroxyethoxy)propanoate
- Product Name
- tert-Butyl 3-(2-hydroxyethoxy)propanoate
- CAS No.
- 671802-00-9
- Chemical Name
- tert-Butyl 3-(2-hydroxyethoxy)propanoate
- Synonyms
- HO-PEG1-CH2CH2COOTBU;OH-PEG1-CH2CH2COOtBu;HO-PEG1-t-Butyl ester;Hydroxy-PEG1-(CH2)2-Boc;Hydroxy-PEG1-t-butyl ester;tert-Butyl 3-(2-hydroxyethoxy)propanoate;2-Methyl-2-propanyl 3-(2-hydroxyethoxy)propanoate;3-(2-hydroxyethoxy)propionic acid tert-butyl ester;3-(2-Hydroxyethoxy)propanoic acid tert-butyl ester;3-(2-Hydroxyethoxy)propanoic acid 1,1-dimethylethyl ester
- CBNumber
- CB82680372
- Molecular Formula
- C9H18O4
- Formula Weight
- 190.24
- MOL File
- 671802-00-9.mol
tert-Butyl 3-(2-hydroxyethoxy)propanoate Property
- Boiling point:
- 274.0±15.0 °C(Predicted)
- Density
- 1.031±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.36±0.10(Predicted)
- form
- liquid
- color
- Yellowish
- Water Solubility
- Water: 100 mg/mL (525.65 mM)
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809905
- Product name
- tert-Butyl3-(2-hydroxyethoxy)propanoate
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- BP-20597
- Product name
- Hydroxy-PEG1-t-butylester
- Purity
- 98%
- Packaging
- 10g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CHM0396313
- Product name
- TERTBUTYL-3-(2-HYDROXYETHOXY)PROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.45
- Updated
- 2021/12/16
- Product number
- CD13006963
- Product name
- tert-Butyl3-(2-hydroxyethoxy)propanoate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $579
- Updated
- 2021/12/16
- Product number
- A143357
- Product name
- tert-Butyl3-(2-hydroxyethoxy)propanoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $826
- Updated
- 2021/12/16
tert-Butyl 3-(2-hydroxyethoxy)propanoate Chemical Properties,Usage,Production
Description
Hydroxy-PEG1-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
tert-Butyl 3-(2-hydroxyethoxy)propanoate is a reactant in the synthesis of hydrophilic aminooxy linked and multivalent disaccharide cellobiose derivatives for chemoselective aldehyde/ketone conjugation
Uses
tert-Butyl 3-(2-hydroxyethoxy)propanoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process.
Synthesis
To a solution of anhydrous ethylene glycol (10 g, 161.1 mmol) in anhydrous THF (40 mL) was added sodium metal (62.0 mg, 2.70 mmol) and stirred at room temperature for 2 hours.Add tert-butyl acrylate (6.90, 53.7 mmol) and stir overnight.After quenching with water, the solvent was THF dried under reduced pressure, and extracted with ethyl acetate and water.The organic layer was separated, washed with brine, and dried over Na 2 SO 4.After filtration and evaporation, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 2:1) to obtain a colorless oil 44 (5.0 g, 26.3 mmol, 49% yield)
tert-Butyl 3-(2-hydroxyethoxy)propanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 3-(2-hydroxyethoxy)propanoate manufacturers
- Product
- Hydroxy-PEG1-t-butyl ester 671802-00-9
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-25