ChemicalBook > CAS DataBase List > tert-Butyl 3-(2-hydroxyethoxy)propanoate

tert-Butyl 3-(2-hydroxyethoxy)propanoate

Product Name
tert-Butyl 3-(2-hydroxyethoxy)propanoate
CAS No.
671802-00-9
Chemical Name
tert-Butyl 3-(2-hydroxyethoxy)propanoate
Synonyms
HO-PEG1-CH2CH2COOTBU;OH-PEG1-CH2CH2COOtBu;HO-PEG1-t-Butyl ester;Hydroxy-PEG1-(CH2)2-Boc;Hydroxy-PEG1-t-butyl ester;tert-Butyl 3-(2-hydroxyethoxy)propanoate;2-Methyl-2-propanyl 3-(2-hydroxyethoxy)propanoate;3-(2-hydroxyethoxy)propionic acid tert-butyl ester;3-(2-Hydroxyethoxy)propanoic acid tert-butyl ester;3-(2-Hydroxyethoxy)propanoic acid 1,1-dimethylethyl ester
CBNumber
CB82680372
Molecular Formula
C9H18O4
Formula Weight
190.24
MOL File
671802-00-9.mol
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tert-Butyl 3-(2-hydroxyethoxy)propanoate Property

Boiling point:
274.0±15.0 °C(Predicted)
Density 
1.031±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.36±0.10(Predicted)
form 
liquid
color 
Yellowish
Water Solubility 
Water: 100 mg/mL (525.65 mM)
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Safety

HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809905
Product name
tert-Butyl3-(2-hydroxyethoxy)propanoate
Packaging
100mg
Price
$50
Updated
2021/12/16
BroadPharm
Product number
BP-20597
Product name
Hydroxy-PEG1-t-butylester
Purity
98%
Packaging
10g
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0396313
Product name
TERTBUTYL-3-(2-HYDROXYETHOXY)PROPANOATE
Purity
95.00%
Packaging
5MG
Price
$495.45
Updated
2021/12/16
Crysdot
Product number
CD13006963
Product name
tert-Butyl3-(2-hydroxyethoxy)propanoate
Purity
95+%
Packaging
10g
Price
$579
Updated
2021/12/16
Ambeed
Product number
A143357
Product name
tert-Butyl3-(2-hydroxyethoxy)propanoate
Purity
98%
Packaging
25g
Price
$826
Updated
2021/12/16
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tert-Butyl 3-(2-hydroxyethoxy)propanoate Chemical Properties,Usage,Production

Description

Hydroxy-PEG1-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

tert-Butyl 3-(2-hydroxyethoxy)propanoate is a reactant in the synthesis of hydrophilic aminooxy linked and multivalent disaccharide cellobiose derivatives for chemoselective aldehyde/ketone conjugation

Uses

tert-Butyl 3-(2-hydroxyethoxy)propanoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis


To a solution of anhydrous ethylene glycol (10 g, 161.1 mmol) in anhydrous THF (40 mL) was added sodium metal (62.0 mg, 2.70 mmol) and stirred at room temperature for 2 hours.Add tert-butyl acrylate (6.90, 53.7 mmol) and stir overnight.After quenching with water, the solvent was THF dried under reduced pressure, and extracted with ethyl acetate and water.The organic layer was separated, washed with brine, and dried over Na 2 SO 4.After filtration and evaporation, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 2:1) to obtain a colorless oil 44 (5.0 g, 26.3 mmol, 49% yield)

tert-Butyl 3-(2-hydroxyethoxy)propanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-Butyl 3-(2-hydroxyethoxy)propanoate manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Hydroxy-PEG1-t-butyl ester 671802-00-9
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-25

671802-00-9, tert-Butyl 3-(2-hydroxyethoxy)propanoateRelated Search:

tert-Butyl N-(((4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)methyl)carbamate 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE HO-PEG12-tBu PEG7-t-butly ester PEG9-t-butly ester HO-PEG10-tBu HO-PEG5-tBu Hydroxy-PEG4-t-butyl ester methyl 2-(2-hydroxyethoxy)acetate HO-PEG9-COOMe

  • tert-Butyl 3-(2-hydroxyethoxy)propanoate
  • HO-PEG1-CH2CH2COOTBU
  • Hydroxy-PEG1-t-butyl ester
  • 3-(2-Hydroxyethoxy)propanoic acid 1,1-dimethylethyl ester
  • 3-(2-Hydroxyethoxy)propanoic acid tert-butyl ester
  • HO-PEG1-t-Butyl ester
  • OH-PEG1-CH2CH2COOtBu
  • Hydroxy-PEG1-(CH2)2-Boc
  • 3-(2-hydroxyethoxy)propionic acid tert-butyl ester
  • Propanoic acid, 3-(2-hydroxyethoxy)-, 1,1-dimethylethyl ester
  • 2-Methyl-2-propanyl 3-(2-hydroxyethoxy)propanoate
  • 671802-00-9
  • peg