4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 119285-07-3
Chemical Name: 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: Palbociclib Impurity 42;Palbociclib Impurity 103;1-Boc-4-(5-amino-2-pyridyl)piperazine;1-Boc-4-(5-amino-2-pyridinyl)-piperazine;1-BOC-4-(5-AMINO-PYRIDIN-2-YL)-PIPERAZINE;4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected;tert-butyl 3-allyl-3-hydroxyazetidine-43-carboxylate;4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected 95%;1-(tert-Butyloxycarbonyl)-4-(5-aminopyridin-2-yl)piperazine;4-(5-amino-2-pyridinyl)-2-piperazinecarboxylic acid tert-butyl ester
CBNumber: CB8277044
Molecular Formula: C14H22N4O2
Formula Weight: 278.35
MOL File: 119285-07-3.mol

More

Less

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:: 98-101°C
Boiling point:: 470.4±45.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 9.35±0.29(Predicted)
color: black gel

More

Less

Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
HazardClass: IRRITANT
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A594050
Product name: 5-Amino-2-(4-BOC-piperazino)pyridine
Packaging: 250mg
Price: $90
Updated: 2021/12/16

TRC

Product number: A594050
Product name: 5-Amino-2-(4-BOC-piperazino)pyridine
Packaging: 500mg
Price: $140
Updated: 2021/12/16

Apolloscientific

Product number: OR15307
Product name: 4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected
Purity: 95%
Packaging: 1g
Price: $176
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-0W
Product name: 4-(5-Aminopyridin-2-yl)piperazine, N1-Boc protected
Packaging: 1g
Price: $208
Updated: 2021/12/16

Matrix Scientific

Product number: 046032
Product name: tert-Butyl 4-(5-amino-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $486
Updated: 2021/12/16

More

Less

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

193902-78-2

119285-07-3

Example 197b Synthesis of tert-butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate 197b: To a 250-mL round-bottomed flask under nitrogen protection was added 1-tert-butylcarbonyl-4-(5-nitro-2-piperidinyl)piperazine 197a (4.0 g, 13.0 mmol), 10% palladium-carbon (wetted, 500 mg) and methanol (130 mL). The reaction system was evacuated and filled with hydrogen and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and filled with nitrogen. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to afford the target compound 197b (3.3 g, 91% yield). Mass spectral data (MS-ESI): [M + H]+ 279.

References

[1] Patent: US2005/182078, 2005, A1. Location in patent: Page/Page column 9; 12
[2] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 14
[3] Chinese Chemical Letters, 2013, vol. 24, # 4, p. 303 - 306
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 16, p. 4779 - 4783
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0753; 0755

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 80 Germany 2 India 2 United Kingdom 6 United States 14 Global 104

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

Shanghai Keepontech Co.,Ltd

Tel: 021-54849683 13601642561
Fax: +86-21-54375689
Email: sales@keepontech.com
Country: China
ProdList: 998
Advantage: 59

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

More

Less

View Lastest Price from 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 119285-07-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 119285-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 119285-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

119285-07-3, 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

TERT-BUTYL 4-(5-FLUORO-2-METHOXYBENZYL)-4-HYDROXYPIPERIDINE-1-CARBOXYLATE tert-butyl 4-(5-iodopyrimidin-2-yl)piperazine-1-carboxylate 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Palbociclib Impurity 7 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine 571188-59-5 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 1,4-bis(4-nitrophenyl)piperazine 1-(5-Nitropyridin-2-yl)piperazine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one 1-BOC-4-(3-AMINO-4-PYRIDINYL)-PIPERAZINE 4-(6-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

1-BOC-4-(5-AMINO-PYRIDIN-2-YL)-PIPERAZINE

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 4-(5-AMINO-2-PYRIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(5-Aminopyridin-2-yl)piperazine-1-carboxylicacidtert-butylester95%

4-(5-Aminopyridin-2-yl)qiperazine-1-carboxylic acid tert-butyl ester

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%

4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected

1-Boc-4-(5-amino-2-pyridinyl)-piperazine

Palbociclib Impurity 42

4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected 95%

4-(5-amino-2-pyridinyl)-2-piperazinecarboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester

1-(tert-Butyloxycarbonyl)-4-(5-aminopyridin-2-yl)piperazine

ert-Butyl4-(5-amino-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxylate

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

tert-butyl 3-allyl-3-hydroxyazetidine-43-carboxylate

Palbociclib Impurity 103

1-Boc-4-(5-amino-2-pyridyl)piperazine

119285-07-3

pharmacetical