2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Product Name: 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
CAS No.: 1013916-37-4
Chemical Name: 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
Synonyms: Palbociclib intermediates;-5-methyL;oro-8-cycL;3-d]pyriMidin-7(8H)-one;Palbociclib Impurity 105;Palbociclib Intermediate2;2-chloro-8-cyclopentyl-5-Me;Palbociclib impurity 703-201;pyrido[2,3-d]pyrimidin-7(8H)-one;2-chloro-8-cyclopentyl-5-Methylpyrido[2
CBNumber: CB62554161
Molecular Formula: C13H14ClN3O
Formula Weight: 263.72
MOL File: 1013916-37-4.mol

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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Property

Melting point:: 176 - 178°C
Boiling point:: 428.0±34.0 °C(Predicted)
Density: 1.346±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 0.82±0.20(Predicted)
color: Yellow to Dark Yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C13H14ClN3O/c1-8-6-11(18)17(9-4-2-3-5-9)12-10(8)7-15-13(14)16-12/h6-7,9H,2-5H2,1H3
InChIKey: BSKNQSYIDZUXQT-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C2C(C)=CC(=O)N(C3CCCC3)C2=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H54363
Product name: 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging: 1g
Price: $176.65
Updated: 2024/03/01

Alfa Aesar

Product number: H54363
Product name: 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging: 5g
Price: $697.65
Updated: 2024/03/01

Alfa Aesar

Product number: H54363
Product name: 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging: 250mg
Price: $55.65
Updated: 2024/03/01

TRC

Product number: C585608
Product name: 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 131623
Product name: 2-Chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity: 97%
Packaging: 25g
Price: $147
Updated: 2021/12/16

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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Usage,Production

Description

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is used as an intermediate for Palbociclib, a CDK 4/6 inhibitor used to treat patients with hormone receptor (HR)-positive, HER-2-negative advanced or metastatic (cancer that has spread) breast cancer.

Uses

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one is used as pharmaceutical intermediate.

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

China 266 India 7 United States 7 Global 280

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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Alfa Aesar

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Jia Xing Isenchem Co.,Ltd

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Tetranov Biopharm

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Adamas Reagent, Ltd.

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View Lastest Price from 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Palbociclib Impurity 9 1013916-37-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-08-13

Career Henan Chemical Co

Product: 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1013916-37-4
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-26

1013916-37-4, 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-oneRelated Search:

4-[6-[(8-cyclopentyl-6-ethenyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 2-Amino-5-bromopyridine Palbociclib Impurity 7 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine 571188-59-5 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 1,4-bis(4-nitrophenyl)piperazine 1-(5-Nitropyridin-2-yl)piperazine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Pyrido[2,3-d]pyriMidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-Methyl-

2-chloro-8-cyclopentyl-5-Me

Palbociclib Intermediate2

Palbociclib intermediates

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (For Palbociclib)

2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one

2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

2-chloro-8-cyclopentyl-5-Methylpyrido[2

3-d]pyriMidin-7(8H)-one

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

oro-8-cycL

pyrido[2,3-d]pyrimidin-7(8H)-one

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one,97%

-5-methyL

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 2-

2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-...

Palbociclib Impurity 105

2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMi

2-chloro-8-cyclopentyl-5-methoyrido-8H-pyrido[ 2,3-D]pyrimidin- 7 - one

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-

2-chloro-8-cyclopentyl-5-methyl-8H-pyrido [2,3-D] pyridine

Palbociclib impurity 703-201

1013916-37-4

Anticancer

1013916-37-4