ChemicalBook > CAS DataBase List > 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Product Name
2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
CAS No.
1013916-37-4
Chemical Name
2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
Synonyms
Palbociclib intermediates;-5-methyL;oro-8-cycL;3-d]pyriMidin-7(8H)-one;Palbociclib Impurity 105;Palbociclib Intermediate2;2-chloro-8-cyclopentyl-5-Me;Palbociclib impurity 703-201;pyrido[2,3-d]pyrimidin-7(8H)-one;2-chloro-8-cyclopentyl-5-Methylpyrido[2
CBNumber
CB62554161
Molecular Formula
C13H14ClN3O
Formula Weight
263.72
MOL File
1013916-37-4.mol
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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Property

Melting point:
176 - 178°C
Boiling point:
428.0±34.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
0.82±0.20(Predicted)
color 
Yellow to Dark Yellow
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C13H14ClN3O/c1-8-6-11(18)17(9-4-2-3-5-9)12-10(8)7-15-13(14)16-12/h6-7,9H,2-5H2,1H3
InChIKey
BSKNQSYIDZUXQT-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C2C(C)=CC(=O)N(C3CCCC3)C2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H54363
Product name
2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging
1g
Price
$176.65
Updated
2024/03/01
Alfa Aesar
Product number
H54363
Product name
2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging
5g
Price
$697.65
Updated
2024/03/01
Alfa Aesar
Product number
H54363
Product name
2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%
Packaging
250mg
Price
$55.65
Updated
2024/03/01
TRC
Product number
C585608
Product name
2-​Chloro-​8-​cyclopentyl-​5-​methyl-​8H-​pyrido[2,​3-​d]​pyrimidin-​7-​one
Packaging
1g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
131623
Product name
2-Chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity
97%
Packaging
25g
Price
$147
Updated
2021/12/16
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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Usage,Production

Description

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is used as an intermediate for Palbociclib, a CDK 4/6 inhibitor used to treat patients with hormone receptor (HR)-positive, HER-2-negative advanced or metastatic (cancer that has spread) breast cancer.

Uses

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one is used as pharmaceutical intermediate.

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

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View Lastest Price from 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Palbociclib Impurity 9 1013916-37-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-13
Career Henan Chemical Co
Product
2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1013916-37-4
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-26

1013916-37-4, 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-oneRelated Search:

4-[6-[(8-cyclopentyl-6-ethenyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 2-Amino-5-bromopyridine Palbociclib Impurity 7 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine 571188-59-5 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 1,4-bis(4-nitrophenyl)piperazine 1-(5-Nitropyridin-2-yl)piperazine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

  • 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
  • Pyrido[2,3-d]pyriMidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-Methyl-
  • 2-chloro-8-cyclopentyl-5-Me
  • Palbociclib Intermediate2
  • Palbociclib intermediates
  • 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (For Palbociclib)
  • 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
  • 2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
  • 2-chloro-8-cyclopentyl-5-Methylpyrido[2
  • 3-d]pyriMidin-7(8H)-one
  • 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
  • oro-8-cycL
  • pyrido[2,3-d]pyrimidin-7(8H)-one
  • 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one,97%
  • -5-methyL
  • 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 2-
  • 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-...
  • Palbociclib Impurity 105
  • 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]
  • 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMi
  • 2-chloro-8-cyclopentyl-5-methoyrido-8H-pyrido[ 2,3-D]pyrimidin- 7 - one
  • 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-
  • 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido [2,3-D] pyridine
  • Palbociclib impurity 703-201
  • 1013916-37-4
  • Anticancer
  • 1013916-37-4