2-(4-Methylpiperazin-1-yl)-5-nitropyridine
- Product Name
- 2-(4-Methylpiperazin-1-yl)-5-nitropyridine
- CAS No.
- 55403-34-4
- Chemical Name
- 2-(4-Methylpiperazin-1-yl)-5-nitropyridine
- Synonyms
- 1-Methyl-4-(5-nitropyridin-2-yl);2-(4-Methylpiperazin-1-yl)-5-nitropyridine;2-(4-Methyl-1-piperazinyl)-5-nitropyridine;Piperazine, 1-methyl-4-(5-nitro-2-pyridinyl)-
- CBNumber
- CB71483287
- Molecular Formula
- C10H14N4O2
- Formula Weight
- 222.24
- MOL File
- 55403-34-4.mol
2-(4-Methylpiperazin-1-yl)-5-nitropyridine Property
- Melting point:
- 108-110°
- storage temp.
- 2-8°C
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B495338
- Product name
- 1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR111574
- Product name
- 1-Methyl-4-(5-nitropyridin-2-yl)piperazine
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- W6942
- Product name
- 1-Methyl-4-(5-nitropyridin-2-yl)piperazine
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 044856
- Product name
- 1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 044856
- Product name
- 1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
- Purity
- >95%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
2-(4-Methylpiperazin-1-yl)-5-nitropyridine Chemical Properties,Usage,Production
Synthesis
109-01-3
4548-45-2
55403-34-4
General procedure for the synthesis of 5-nitro-2-(4-methyl-1-piperazinyl)pyridine from N-methylpiperazine and 2-chloro-5-nitropyridine: 2-chloro-5-nitropyridine (3.16 g, 20.0 mmol), N-methylpiperazine (2.00 g, 20.0 mmol) and potassium carbonate (2.76 g, 20.0 mmol) were reacted in a N,N- Dimethylformamide (DMF) in a stirred mixture was heated to 100 °C and reacted for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The obtained residue was purified by fast column chromatography (silica gel as stationary phase, eluent was a 10:90 ethanol:ethyl acetate mixture containing 2% ammonia) to afford 5-nitro-2-(4-methyl-1-piperazinyl)pyridine as an off-white solid in the yield of 4.0 g (90% yield), and the structure of the product was confirmed by nuclear magnetic resonance (NMR) analysis.
References
[1] Molecules, 2012, vol. 17, # 4, p. 4703 - 4716
[2] Patent: US2004/167030, 2004, A1. Location in patent: Page 9
[3] Patent: US2015/266825, 2015, A1. Location in patent: Paragraph 1279; 1280
[4] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 322 - 333
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1362 - 1365
2-(4-Methylpiperazin-1-yl)-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-Methylpiperazin-1-yl)-5-nitropyridine manufacturers
- Product
- 2-(4-Methylpiperazin-1-yl)-5-nitropyridine 55403-34-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03