ChemicalBook > CAS DataBase List > 2-(4-Methylpiperazin-1-yl)-5-nitropyridine

2-(4-Methylpiperazin-1-yl)-5-nitropyridine

Product Name
2-(4-Methylpiperazin-1-yl)-5-nitropyridine
CAS No.
55403-34-4
Chemical Name
2-(4-Methylpiperazin-1-yl)-5-nitropyridine
Synonyms
1-Methyl-4-(5-nitropyridin-2-yl);2-(4-Methylpiperazin-1-yl)-5-nitropyridine;2-(4-Methyl-1-piperazinyl)-5-nitropyridine;Piperazine, 1-methyl-4-(5-nitro-2-pyridinyl)-
CBNumber
CB71483287
Molecular Formula
C10H14N4O2
Formula Weight
222.24
MOL File
55403-34-4.mol
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2-(4-Methylpiperazin-1-yl)-5-nitropyridine Property

Melting point:
108-110°
storage temp. 
2-8°C
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B495338
Product name
1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR111574
Product name
1-Methyl-4-(5-nitropyridin-2-yl)piperazine
Packaging
1g
Price
$70
Updated
2021/12/16
AK Scientific
Product number
W6942
Product name
1-Methyl-4-(5-nitropyridin-2-yl)piperazine
Packaging
5g
Price
$124
Updated
2021/12/16
Matrix Scientific
Product number
044856
Product name
1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
Purity
>95%
Packaging
500mg
Price
$181
Updated
2021/12/16
Matrix Scientific
Product number
044856
Product name
1-Methyl-4-(5-nitro-2-pyridinyl)piperazine
Purity
>95%
Packaging
1g
Price
$228
Updated
2021/12/16
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2-(4-Methylpiperazin-1-yl)-5-nitropyridine Chemical Properties,Usage,Production

Synthesis

109-01-3

4548-45-2

55403-34-4

General procedure for the synthesis of 5-nitro-2-(4-methyl-1-piperazinyl)pyridine from N-methylpiperazine and 2-chloro-5-nitropyridine: 2-chloro-5-nitropyridine (3.16 g, 20.0 mmol), N-methylpiperazine (2.00 g, 20.0 mmol) and potassium carbonate (2.76 g, 20.0 mmol) were reacted in a N,N- Dimethylformamide (DMF) in a stirred mixture was heated to 100 °C and reacted for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The obtained residue was purified by fast column chromatography (silica gel as stationary phase, eluent was a 10:90 ethanol:ethyl acetate mixture containing 2% ammonia) to afford 5-nitro-2-(4-methyl-1-piperazinyl)pyridine as an off-white solid in the yield of 4.0 g (90% yield), and the structure of the product was confirmed by nuclear magnetic resonance (NMR) analysis.

References

[1] Molecules, 2012, vol. 17, # 4, p. 4703 - 4716
[2] Patent: US2004/167030, 2004, A1. Location in patent: Page 9
[3] Patent: US2015/266825, 2015, A1. Location in patent: Paragraph 1279; 1280
[4] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 322 - 333
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1362 - 1365

2-(4-Methylpiperazin-1-yl)-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-Methylpiperazin-1-yl)-5-nitropyridine manufacturers

Career Henan Chemical Co
Product
2-(4-Methylpiperazin-1-yl)-5-nitropyridine 55403-34-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-03

55403-34-4, 2-(4-Methylpiperazin-1-yl)-5-nitropyridineRelated Search:

1-ISOBUTYL-4-(5-NITROPYRIDIN-2-YL)PIPERAZINE 2-[4-(5-NITROPYRIDIN-2-YL)PIPERAZIN-1-YL]ETHANOL 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-(4-Methylpiperazin-1-yl)-5-nitropyridine 1-(5-nitro-2-pyridinyl)-4-phenylpiperazine 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE 2-CHLORO-1-[4-(5-NITRO-2-PYRIDYL)PIPERAZINO]ETHAN-1-ONE

  • 2-(4-Methylpiperazin-1-yl)-5-nitropyridine
  • 1-Methyl-4-(5-nitropyridin-2-yl)
  • 2-(4-Methyl-1-piperazinyl)-5-nitropyridine
  • Piperazine, 1-methyl-4-(5-nitro-2-pyridinyl)-
  • 55403-34-4
  • Amines and Anilines
  • Heterocycles